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Open Source SynBio?

If the controversy over genetically modified organisms (GMOs) tells us something indisputable, it is this: GMO food products from corporations like Monsanto are suspected to endanger health. On the other hand, an individual’s right to genetically modify and even synthesize entire organisms as part of his dietary or medical regimen could someday be a human right.
The suspicion that agri-giant companies do harm by designing crops is legitimate, even if evidence of harmful GMOs is scant to absent. Based on their own priorities and actions, we should have no doubt that self-interested corporations disregard the rights and wellbeing of local producers and consumers. This makes agri-giants producing GMOs harmful and untrustworthy, regardless of whether individual GMO products are actually harmful.
Corporate interference in government of the sort opposed by the Occupy Movement is also connected with the GMO controversy, as the US government is accused of going to great lengths to protect “stakeholders” like Monsanto via the law. This makes the GMO controversy more of a business and political issue rather than a scientific one, as I argued in an essay published at the Institute for Ethics and Emerging Technologies (IEET). Attacks on science and scientists themselves over the GMO controversy are not justified, as the problem lies solely with a tiny handful of businessmen and corrupt politicians.
An emerging area that threatens to become as controversial as GMOs, if the American corporate stranglehold on innovation is allowed to shape its future, is synthetic biology. In his 2014 book, Life at the Speed of Light: From the Double Helix to the Dawn of Digital Life, top synthetic biologist J. Craig Venter offers powerful words supporting a future shaped by ubiquitous synthetic biology in our lives:

“I can imagine designing simple animal forms that provide novel sources of nutrients and pharmaceuticals, customizing human stem cells to regenerate a damaged, old, or sick body. There will also be new ways to enhance the human body as well, such as boosting intelligence, adapting it to new environments such as radiation levels encountered in space, rejuvenating worn-out muscles, and so on”

In his own words, Venter’s vision is no less than “a new phase of evolution” for humanity. It offers what Venter calls the “real prize”: a family of designer bacteria “tailored to deal with pollution or to absorb excess carbon dioxide or even meet future fuel needs”. Greater than this, the existing tools of synthetic biology are transhumanist in nature because they create limitless means for humans to enhance themselves to deal with harsher environments and extend their lifespans.
While there should be little public harm in the eventual ubiquity of the technologies and information required to construct synthetic life, the problems of corporate oligopoly and political lobbying are threatening synthetic biology’s future as much as they threaten other facets of human progress. The best chance for an outcome that will be maximally beneficial for the world relies on synthetic biology taking a radically different direction to GM. That alternative direction, of course, is an open source future for synthetic biology, as called for by Canadian futurist Andrew Hessel and others.
Calling himself a “catalyst for open-source synthetic biology”, Hessel is one of the growing number of experts who reject biotechnology’s excessive use of patents. Nature notes that his Pink Army Cooperative venture relies instead on “freely available software and biological parts that could be combined in innovative ways to create individualized cancer treatments — without the need for massive upfront investments or a thicket of protective patents”.
While offering some support to the necessity of patents, J. Craig Venter more importantly praises the annual International Genetically Engineered Machine (iGEM) competition in his book as a means of encouraging innovation. He specifically names the Registry of Standard Biological Parts, an open source library from which to obtain BioBricks, and describes this as instrumental for synthetic biology innovation. Likened to bricks of Lego that can be snapped together with ease by the builder, BioBricks are prepared standard pieces of genetic code, with which living cells can be newly equipped and operated as microscopic chemical factories. This has enabled students and small companies to reprogram life itself, taking part in new discoveries and innovations that would have otherwise been impossible without the direct supervision of the world’s best-trained teams of biologists.
There is a similar movement towards popular synthetic biology by the name of biohacking, promoted by such experts as Ellen Jorgensen. This compellingly matches the calls for greater autonomy for individuals and small companies in medicine and human enhancement. Unfortunately, despite their potential to greatly empower consumers and farmers, such developments have not yet found resonance with anti-GMO campaigners, whose outright rejection of biotechnology has been described as anti-science and “bio-luddite” by techno-progressives. It is for this reason that emphasizing the excellent potential of biotechnology for feeding and fuelling a world plagued by dwindling resources is important, and a focus on the ills of big business rather than imagined spectres emerging from science itself is vital.
The concerns of anti-GMO activists would be addressed better by offering support to an alternative in the form of “do-it-yourself” biotechnology, rather than rejecting sciences and industries that are already destined to be a fundamental part of humanity’s future. What needs to be made is a case for popular technology, in hope that we can reject the portrayal of all advanced technology as an ally of powerful states and corporations and instead unlock its future as a means of liberation from global exploitation and scarcity.
While there are strong arguments that current leading biotechnology companies feel more secure and perform better when they retain rigidly enforced intellectual property rights, Andrew Hessel rightly points out that the open source future is less about economic facts and figures than about culture. The truth is that there is a massive cultural transition taking place. We can see a growing hostility to patents, and an increasing popular enthusiasm for open source innovation, most promisingly among today’s internet-borne youth.
In describing a cultural transition, Hessel is acknowledging the importance of the emerging body of transnational youth whose only ideology is the claim that information wants to be free, and we find the same culture reflected in the values of organizations like WikiLeaks. Affecting every facet of science and technology, the elite of today’s youth are crying out for a more open, democratic, transparent and consumer-led future at every level.

By Harry J. Bentham - More articles by Harry J. Bentham

Originally published at h+ Magazine on 21 August 2014

The Promise Of A Cancer Drug Developed By Artificial Intelligence

Ariel Schwartz — Fast Company


BPM 31510 is just another cancer drug in human development trials, except for one thing. Scientists didn’t toil away in labs to come up with it; artificial intelligence did.

The cancer drug development process is costly and time-consuming. On average, it takes 24 to 48 months and upwards of $100 million to find a suitable candidate. Add that to the fact that 95% of all potential drugs fail in clinical trials, and the inefficiencies of the whole drug-discovery machine really become apparent.

Backed by real estate billionaire Carl Berg, eponymous biotech startup Berg wants to use artificial intelligence to design cancer drugs that are cheaper, have fewer side effects, and can be developed in half the time it normally takes. BPM 31510 is the first of Berg’s drugs to get a real-world test.

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What Else Could Smart Contact Lenses Do?

By Suzanne Jacobs — MIT Technology Review

Last week Google and Novartis announced that they’re teaming up to develop contact lenses that monitor glucose levels and automatically adjust their focus. But these could be just the start of a clever new product category. From cancer detection and drug delivery to reality augmentation and night vision, our eyes offer unique opportunities for both health monitoring and enhancement.

“Now is the time to put a little computer and a lot of miniaturized technologies in the contact lens,” says Franck Leveiller, head of research and development in the Novartis eye care division.

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Promising Early Results on Universal Blood Test for Cancer

Written By: — Singularity Hub

Absent an outright cure, it’s thought that early diagnosis of terminal diseases like cancer make treatment more effective and raise the probability of survival. But diagnosis is not always straightforward and often requires costly and invasive tests.

Simple, cheap, and accurate tests looking for the markers of disease may help.

One such method may be a blood test for cancer from University of Bradford researchers. The Lymphocyte Genome Sensitivity (LGS) test observes how DNA in lymphocytes (a type of white blood cell) is damaged under varying intensities of ultraviolet (UV) light.

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Debate featuring Anders Sandberg on the future of human cloning

Anders Sandberg, a member of the advisory board for the Lifeboat Foundation, recently took part in a panel debate on the future of human cloning produced by the Institute of Art and Ideas.

Debate blurb:

Human cloning is anathema to most of us conjuring up Metropolis visions of identical humans serving tyrannical masters. But might this be a mistaken horror story? Could human cloning instead lead to medical breakthroughs and the end to infertility?

Debate panel:

Dolly the Sheep embryologist Sir Ian Wilmut, outspoken Oxford bioethicist and transhumanist Anders Sandberg and radical sociologist Hilary Rose.

Watch Planet of the Clones on IAI.TV

Tiny 3D-Printed Bio-Bots Are Propelled by Muscle Cells

Written By: — Singularity Hub

Robots come in all shapes and sizes—some are mechanical, and some aren’t. Last year, a team of scientists from the University of Illinois at Urbana-Champaign made a seven-millimeter-long 3D printed robot powered by the heart cells of a rat.

The device, made of 3D printed hydrogel—a water-based, biologically compatible gel—had two feet, one bigger than the other. The smaller, longer foot was coated in heart cells. Each time the cells contracted, the robot would crawl forward a few millimeters.

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Woman Grows A Nose On Her Spine After Stem Cell Experiment

BySarah Fecht- Popular Science
https://lifeboat.com/blog.images/woman-grows-a-nose-on-her-spine-after-stem-cell-experiment2.jpg

Eight years ago, doctors took nasal tissue samples and grafted them onto the spines of 20 quadriplegics. The idea was that stem cells within the nasal tissue might turn into neurons that could help repair the damaged spinal cord, and the experiment actually worked a few of the patients, who regained a little bit of sensation. But it didn’t go well for one woman in particular, who not only didn’t experience any abatement in her paralysis, but recently started feeling pain at the site of the implant. When doctors took a closer look, they realized she was growing the beginnings of a nose on her spine, New Scientist reports.

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Delivering Capsules of Stem Cells Helps Repair Injured Bones

Written By: — Singularity Hub

For the recorder of potentially breakthrough medical technology, sometimes it seems that the list is just so many applications of three new technologies: smaller electronics, new materials and stem cells. Any electronic device set up to function inside the body relies on smaller, flexible parts and new biocompatible casings, for example. Stem cells, properly manipulated, seem capable of mending nearly everything that ails us.

But the details of how best to cultivate certain kinds of cells and spur them to function in the body are still being worked out. According to University of Rochester researchers, materials science may be a big help.

One trouble with stem cells is that they don’t stay put. When doctors put cardiovascular progenitor cells in the heart to heal damage from a heart attack, the cells are whisked away in the bloodstream in a matter of hours.

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GMOs are not the problem, per se

. @hjbentham . @clubofinfo . @dissidentvoice_ .#tech .#gmo .#ethics . @ieet .

Since giving my support to the May 24 march against Monsanto, I have taken the time to review some of the more unusual opinions in the debate over genetically-modified organisms (GMOs). The enthusiasts for technological development as a means of eliminating scarcity and disparity view GMOs favorably. These enthusiasts include Ramez Naam, whose book The Infinite Resource (2013) argues for human ingenuity as a sufficient force to overcome all resources shortages.
On the other end of the spectrum, alarmists like Daniel Estulin and William Engdahl argue that GMOs are actually part of a deliberate plot to burden poor nations and reduce their populations by creating illness and infertility. Such fringe figures in the alter-globalization movement regard big pharmaceutical companies, chemical companies and agri-giants as involved in a conspiracy to create a docile and dependent population. Are the opinions of either Naam or Estulin well-informed, or are they both too sensational?
Most commentators on the GMO controversy, unfortunately, seem to lean towards either the enthusiast or alarmist categories as described. Reason is often lacking on both sides, as people either blindly leap onto the GMO bandwagon as something tantamount to human progress, or they reject all biotechnology as evil by renewing the fallacy that unnatural actions are necessarily bad. The only thing both sides seem to have in common is their resistance to the Malthusian Club of Rome’s insinuations that overpopulation has to be rolled back to save the Earth’s resources.
Ramez Naam persuades us that the fire of human intellect can overcome our limited resources and allow tens of billions of people to exist on our planet without consuming all natural resources. Estulin and Engdahl reject the Club of Rome on the basis that resource limitations do not really exist and the analysis of the Club of Rome is simply aimed at justifying control of the Earth’s resources by the cherished few “elites”.
The truth rests somewhere between what the alarmist fringe critics of GMOs and the techno-progressive enthusiasts are trying to tell us. To be truthful, there is a serious controversy involving GMOs, but it is no outlandish conspiracy in any sense. It is merely an extension of the problem of greed that has burdened mankind for as long as feudal lords or capitalists have been privileged to put their selfish interests above the common good. The problem with GMOs is neither the nature of GM technology, nor something mysterious that takes place in the process of genetic modification. It is the nature of the businesses tasked with running this industry.
Whether or not certain GMOs on the market today actually cause cancer and infertility is irrelevant to the real debate. The problem is that we can guarantee that the companies engineering these organisms do not care if they cause health problems. They are only interested in downplaying or blocking bad news, and putting out constant marketing and good news about themselves. Typical of any fiercely monopolistic firm, this is not an honest relationship with the public, and corresponds to the prevailing belief in profit as the exclusive priority. For their game to be worth playing, they have to put increasing yields, shelf life and resistance to pathogens above anything else when designing crops. They have no choice than to do this, from their perspective, because the alternative is to allow themselves to be outperformed by their rivals.
The fact that corporations put their own profit above health is a systemic issue in the world economy, and it is already known to the majority of consumers. We face it every day. Most of the fast food served by multinational fast food companies is accepted to be unhealthy, so the claim that giant food companies have little interest in our health is not a conspiracy theory. It is only a rational suspicion that the agricultural producers of seeds will also put profit over the long-term health of consumers and the interests of local farmers.
In theory, genetic modification could lead not only to higher yields but healthier food. Unfortunately, the businesses involved only really care about beating competition and becoming the best supplier. This behavior poisons everything, perhaps literally, now that these companies have been entrusted to define the toxicity in crops as a defense against pests. What we can learn from this that the problem is not GMOs per se, but the aggressive greed of the corporations who desire the oligopoly on food production via GM technology.
The public harm caused by giant firms, especially when they practice their ability to lobby the state itself, already runs very deep in most facets of life. The more significant the tools made available to such firms, the greater the potential for harm. Even if specific specimens are not harmful and can be proven completely benign, the fact is that GMOs open up an unacceptable avenue for unprecedented harm and malignant corporate interests invading people’s innards. It is this, rather than the whole science of genetic modification, that should be opposed and protested against.
Genetic modification and synthetic biology do not need to be new instruments of oligopoly and monopoly. There is a benign alternative to foolishly entrusting the mastery and ownership of living organisms to greedy multinational leviathans. We can look into “biohacking”, as popularized by science and technology enthusiasts who favor the empowerment of individuals and small businesses rather than corporations. There is a strong nod in this direction in J. Craig Venter’s book, Life at the Speed of Light (2013), in which he envisages living organisms being quickly customized and modified by lone individuals with the technology of synthetic biology. Such a development would transform society for the better, eliminating any need to trust an unsympathetic and self-interested corporation like Monsanto.
DIY genetic engineering is already possible. DIY means the product will be entirely disinfected from corporate greed, and adhere to your own specifications. They would not be able to put their profit above your health, because they would not get the chance. With this, biohackers can already genetically modify organisms for their own benefit. The extent to which farmers can begin to modify their own crops using comparable technology is not yet clear, but the development nevertheless represents an extraordinary possibility.
What if farmers and consumers could decide genetically modify their own food? In that case, it would not be the profit-oriented poison that is being consumed at so many different levels as a result of corporate greed. Crops would be modified only insofar as the modification will meet the farmer’s own needs, and all the technology for this process could be open-source. This hypothetical struggle for DIY genetic engineering rather than corporate genetic engineering would be comparable to the open-source and piracy battles already raging over digital technology.
Of course, some new hazards could still conceivably emerge from DIY genetic modification, if the technology for it should become ubiquitous. However, the only risk would be from individual farmers rather than unaccountable corporations. This way, we would be moving away from giving irresponsible and vicious companies the ability to threaten health. Instead, we would be moving towards giving back individuals more control over their own diets. Of course, abuse would still occur, but it would not have global consequences or frighten millions of people in the way that current genetic engineering does.
In sum, there is no reason to complain that genetic modification is perilous in its own right. However, there is always peril in giving a great social responsibility to a profit-hungry corporation. In much the same way that large firms have captured the state machinery of our liberal democratic states to serve their greedy interests, we should expect them to be subverting health and the public good for profit.
The complex dilemma over GMOs requires not an anti-scientific or neo-Luddite reaction, but an acknowledgement that intertwined monopolistic, statist and hegemonic ambitions lead to the retardation of technology rather than progress. I have made this very case in an essay at the techno-politics magazine ClubOfINFO, and I consider it to be an important detail to keep in mind as the GMO controversy rages.

By Harry J. Bentham - More articles by Harry J. Bentham

Originally published at Dissident Voice on 23 June 2014

Bulletproof Coffee, The New Power Drink Of Silicon Valley

By — Fast Company

Cloud computing pioneer Dave Asprey took a trip to Tibet in 2004 to learn how to meditate. But it was the yak-butter tea he tried there that ended up transforming his life.

“I had so much more energy and I didn’t feel sick at the altitude at all. I realized: There’s something going on here. I just felt so good, I’d never go back to a coffee maker with grinder combination” he remembers. He returned home and spent several years fiddling with ingredients, aiming for “a hot version of a Frappuccino without the milk and sugar.” He started with a base of coffee instead of tea because he’s an aficionado; he says he got his only undergraduate “A” the semester he discovered espresso. And the ban on milk and sugar was one of the many biohacks he had practiced over 15 years (and $300,000 in doctors and 3-D radioactive scans of his brain metabolism) trying to rid himself of “brain fog” and 100 pounds of extra weight.

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