Zapping your nerves to jumpstart the blood clotting process.
Category: biotech/medical – Page 3,170
Protein that promotes ‘cell-suicide’ could revolutionise eye cancer treatment
More progress with cancer and using a similar approach to senolytics, no surprise really as cancer and senescent cell share a lot of common ground and approach that work with one may well work with the other if they are aimed at inducing apoptosis.
Apoptosis, or programmed cell death, is a rapid and irreversible process to efficiently eliminate dysfunctional cells. A hallmark of cancer is the ability of malignant cells to evade apoptosis.
Dr Luminita Paraoan, from the University’s Department of Eye and Vision Science in the Institute of Ageing and Chronic Disease, has published new findings in the British Journal of Cancer that identify the requirement of a protein called p63 for the initiation of apoptosis in UM.
Chromosome 3 is one of the 23 pairs of chromosomes in humans. People normally have two copies of each chromosome. One part of chromosome 3 contains the gene for the protein p63. Unfortunately people with aggressive (resistant to apoptosis) UM do not have this part and therefore do not have the p63 protein.
World Patent Marketing Success Team Announces the Gamete Manipulator, a Medical Invention That Facilitates in Manipulating Micro-Sized Materials
Very cool.
World Patent Marketing, a vertically integrated manufacturer and engineer of patented products, introduces the Gamete Manipulator, a medical invention that will allow people to easily move micro-sized materials.
“The healthcare industry is worth $3 trillion,” says Scott Cooper, CEO and Creative Director of World Patent Marketing. “People still require medical attention even during economic downturns so there is a consistent demand for this industry.”
“Medical practice is extremely difficult and requires years of hard work,” says Jerry Shapiro, Director of Manufacturing and World Patent Marketing Inventions. “It’s important that practitioners have the proper tools for the job. This medical intervention will help will precise procedures.”
Logic of Signaling
Why Synbio computing is where we ultimately want to more and more progress towards especially once the basic infrastructure is updated with technology like QC.
Cells are often likened to computers, running an operating system that receives signals, processes their input, and responds, according to programming, with cellular output. Yet untangling computer-like pathways in cells is anything but simple, say Denise Montell, professor at the University of California, Santa Barbara, and Aviv Regev, a Howard Hughes Medical Institute investigator at the Massachusetts Institute of Technology and the Broad Institute. However, both are eager to try and will outline their latest efforts at the “Logic of Signaling” symposium at the 2016 ASCB Annual Meeting.
“My lab is understanding how cells maintain and build normal tissues. We’re studying cellular behaviors that underlie normal behavior and tumor metastasis, a great unsolved question in cancer,” Montell said. Her lab recently discovered that cells can bounce back from the brink of apoptotic cell death. “This wasn’t known before so now we’re looking at how cells do it, when do they do it, under what circumstances, and what does it mean,” Montell said.
To track these near-death experiences in cells the Montell lab generated a genetically coded sensor in Drosophila. The researchers expected the mechanism to be a stress response, but they found that it was normal during development. “It makes sense retrospectively,” Montell explained, pointing to neuronal development as an example. “You produce way more neurons that you need, and the neurons compete for trophic factors. If a group of cells are competing for trophic factors, then one cell starts to die, but if it gets more trophic factor, it could bounce back.”
How the CRISPR Patent Fight Could Shape the Future of Genetic Engineering
On Tuesday, the two feuding parties of the CRISPR gene editing patent fight entered the boxing ring: attorneys for each side made oral arguments before three-judge panel, in a case that not only puts billions of potential dollars at stake, but could define the future of genetic engineering.
Rhythm of breathing affects memory and fear
Northwestern Medicine scientists have discovered for the first time that the rhythm of breathing creates electrical activity in the human brain that enhances emotional judgments and memory recall.
These effects on behavior depend critically on whether you inhale or exhale and whether you breathe through the nose or mouth.
In the study, individuals were able to identify a fearful face more quickly if they encountered the face when breathing in compared to breathing out. Individuals also were more likely to remember an object if they encountered it on the inhaled breath than the exhaled one. The effect disappeared if breathing was through the mouth.
Scientists find that for stem cells to be healthy, telomere length has to be just right
The Goldilocks zone with telomere length is the key.
Ever since researchers connected the shortening of telomeres—the protective structures on the ends of chromosomes—to aging and disease, the race has been on to understand the factors that govern telomere length. Now, scientists at the Salk Institute have found that a balance of elongation and trimming in stem cells results in telomeres that are, as Goldilocks would say, not too short and not too long, but just right.
The finding, which appears in the December 5, 2016, issue of Nature Structural & Molecular Biology, deepens our understanding of stem cell biology and could help advance stem cell-based therapies, especially related to aging and regenerative medicine.
“This work shows that the optimal length for telomeres is a carefully regulated range between two extremes,” says Jan Karlseder, a professor in Salk’s Molecular and Cell Biology Laboratory and senior author of the work. “It was known that very short telomeres cause harm to a cell. But what was totally unexpected was our finding that damage also occurs when telomeres are very long.”
Artificial intelligence and the evolution of the fractal economy
Money makes the world go round, or so they say. Payments, investments, insurance and billions of transactions are the beating heart of a fractal economy, which echoes the messy complexity of natural systems, such as the growth of living organisms and the bouncing of atoms.
Financial systems are larger than the sum of their parts. The underlying rules that govern them might seem simple, but what surfaces is dynamic, chaotic and somehow self-organizing. And the blood that flows through this fractal heartbeat is data.
Today, 2.5 exabytes of data are being produced daily. That number is expected to grow to 44 zettabytes a day by 2020 (Source: GigaOm). This data, along with interconnectivity, correlation, predictive analytics and machine learning, provides the foundation for our AI-powered future.
CellAge: Targeting Senescent Cells With Synthetic Biology
The fourth Lifespan.io campaign and CellAge are using synthetic biology to create an accurate aging biomarker for senescent cells and a new therapy for precision targeting of those problem cells. Senescent cells are one of the processes of aging and this could change the way we age.
Lifespan.io is proud to present our fourth rejuvenation biotechnology project!
As we age our bodies accumulate damage in the form of dysfunctional cells that have entered a state called “senescence”, which secrete toxic signals that can lead to chronic inflammation, higher rates of cancer and additional aging-related conditions.
In order to address this CellAge, an Edinburgh based startup, has just launched a new Lifespan.io campaign to develop methods that will help researchers target, and eventually remove, these cells from the body and thereby assist in restoring it to youthful functionality.
Central to their project is the development of new synthetic DNA promoters which are specific to senescent cells, as promoters that are currently being used to track them, such as the p16 gene promoter, have various limitations. If successful, they will follow this up by validating gene therapies for senescent cell removal, initially for patients with progeroid syndromes, those who have undergone radiotherapy, and eventually those with age-related disease.