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Category: biotech/medical – Page 315

Novel AI-powered imaging technique shows promise in evaluating patients for percutaneous coronary intervention

Patients with narrowing of at least 50% in three major coronary arteries did equally well when treated with a minimally invasive stent placement guided either by ultrasound-based imaging or by a novel, artificial-intelligence-powered (AI), non-invasive imaging technique derived from angiography, researchers reported at the American College of Cardiology’s Annual Scientific Session (ACC.25) on March 30 in Chicago. The work was simultaneously published in The Lancet.

“This is the first such study to be conducted in patients with angiographically significant lesions,” said Jian’an Wang, MD, a professor in the Heart Center at The Second Affiliated Hospital of Zhejiang University School of Medicine in Hangzhou, China, and the study’s senior author. “Patients whose evaluation was non-invasively guided by the novel, AI-powered technique underwent approximately 10% fewer procedures, and their outcomes were comparable with those for patients whose evaluation was guided by a commonly used ultrasound-based imaging technique.”

The study, known as FLAVOUR II, met its primary endpoint, a composite of death, a heart attack or need for a repeat procedure at one year, Wang said.

Programmable pixels could advance infrared light applications

Without the ability to control infrared light waves, autonomous vehicles wouldn’t be able to quickly map their environment and keep “eyes” on the cars and pedestrians around them; augmented reality couldn’t display realistic 3D displays; doctors would lose an important tool for early cancer detection. Dynamic light control allows for upgrades to many existing systems, but complexities associated with fabricating programmable thermal devices hinder availability.

A new active metasurface, the electrically-programmable graphene field effect transistor (Gr-FET), from the labs of Sheng Shen and Xu Zhang in Carnegie Mellon University’s College of Engineering, enables the control of mid-infrared states across a wide range of wavelengths, directions, and polarizations. This enhanced control enables advancements in applications ranging from infrared camouflage to personalized health monitoring.

“For the first time, our active metasurface devices exhibited the monolithic integration of the rapidly modulated temperature, addressable pixelated imaging, and resonant infrared spectrum,” said Xiu Liu, postdoctoral associate in mechanical engineering and lead author of the paper published in Nature Communications. “This breakthrough will be of great interest to a wide range of infrared photonics, , biophysics, and thermal engineering audiences.”

A breakthrough moment: Researchers discover new class of antibiotics

The last time a new class of antibiotics reached the market was nearly three decades ago—but that could soon change, thanks to a discovery by researchers at McMaster University.

A team led by researcher Gerry Wright has identified a strong candidate to challenge even some of the most drug-resistant bacteria on the planet: a called lariocidin. The findings were published in the journal Nature on March 26, 2025.

The discovery of the all-new class of antibiotics responds to a critical need for new antimicrobial medicines, as bacteria and other microorganisms evolve new ways to withstand existing drugs. This phenomenon is called antimicrobial resistance—or AMR—and it’s one of the top global public health threats, according to the World Health Organization.

Critical blood defense receptor CD163 mapped for first time

CD163 might not be the most exciting name in the world, but behind it lies one of the body’s most important defense receptors, which steps in when red blood cells break down and release harmful hemoglobin. Now, researchers at Aarhus University are the first in the world to have mapped how CD163 functions. The findings are published in the journal Nature Communications.

When infections such as malaria take hold in the body, can be severely affected and risk breaking down. When that happens, hemoglobin is released into the bloodstream, potentially causing oxidative damage.

The damage occurs because cells are exposed to reactive oxygen molecules, which form in the bloodstream when oxygen comes into contact with free hemoglobin. If the body is exposed to excessive , it can cause blood vessel damage, , inflammation, and in vital organs.

Quantum fiber optics in the brain enhance processing, may protect against degenerative diseases

The effects of quantum mechanics—the laws of physics that apply at exceedingly small scales—are extremely sensitive to disturbances. This is why quantum computers must be held at temperatures colder than outer space, and only very, very small objects, such as atoms and molecules, generally display quantum properties.

By quantum standards, are quite hostile environments: they’re warm and chaotic, and even their fundamental components—such as cells—are considered very large.

But a group of theoretical and experimental researchers has discovered a distinctly quantum effect in biology that survives these difficult conditions and may also present a way for the brain to protect itself from like Alzheimer’s.

Abstract: An innovative enabling whole-body PET imaging across several types of malignant tumors!

Lei Xia et al. report on a B7H3-targeting radiotracer for PET imaging of various malignant tumors and for non-invasive screening of B7H3 expression:

The figure shows dynamic PET imaging of selected organs using the radiolabled 68Ga-B7H3-BCH probe.

1Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Research, Investigation and Evaluation of Radiopharmaceuticals, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China and.

2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Pathology, Peking University Cancer Hospital and Institute, Beijing, China.

3Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.

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