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Category: biotech/medical – Page 30

AI turns printer into a partner in tissue engineering

In 3D bioprinting, researchers use living cells to create functional tissues and organs. Instead of printing with plastic, they print with living cells. This comes with great challenges. Cells are fragile and wouldn’t survive a regular 3D . That’s why Levato’s team developed a special bio-ink, a mix of living cells and nourishing gels that protect the cells during the printing process.

With the advancements in bio-inks, layer-by-layer 3D bioprinting became possible. But this method is still time-consuming and puts a lot of stress on the cells. Researchers from Utrecht came up with a solution: volumetric bioprinting.

Volumetric bioprinting is faster and gentler on cells. Using cell-friendly laser light, a 3D structure is created all at once. “To build a structure, we project a series of light patterns into a spinning tube filled with light-sensitive gel and cells,” Levato explains. “Where the light beams converge, the material solidifies. This creates a full 3D object in one go, without having to touch the cells.” To do this, it is crucial to know exactly where the cells are in the gel. GRACE now makes that possible.

Treatment For Psychosis May Be ‘Fundamentally Flawed’, Study Finds

For decades, psychiatrists have treated psychosis as if it were separate conditions. People experiencing hallucinations and delusions might be diagnosed with schizophrenia, bipolar disorder, severe depression and related diagnoses, and receive completely different treatments based on diagnosis.

But new research suggests this approach may be fundamentally flawed.

Our latest study, published in JAMA Psychiatry, reveals that the brain changes driving psychotic symptoms are remarkably similar across these supposedly distinct mental health conditions. The findings could change how doctors choose treatments for the millions of people worldwide who experience psychosis.

ASI Risks: Similar premises, opposite conclusions | Eliezer Yudkowsky vs Mark Miller

A debate/discussion on ASI (artificial superintelligence) between Foresight Senior Fellow Mark S. Miller and MIRI founder Eliezer Yudkowsky. Sharing similar long-term goals, they nevertheless reach opposite conclusions on best strategy.

“What are the best strategies for addressing risks from artificial superintelligence? In this 4-hour conversation, Eliezer Yudkowsky and Mark Miller discuss their cruxes for disagreement. While Eliezer advocates an international treaty that bans anyone from building it, Mark argues that such a pause would make an ASI singleton more likely – which he sees as the greatest danger.”

What are the best strategies for addressing extreme risks from artificial superintelligence? In this 4-hour conversation, decision theorist Eliezer Yudkowsky and computer scientist Mark Miller discuss their cruxes for disagreement.

They examine the future of AI, existential risk, and whether alignment is even possible. Topics include AI risk scenarios, coalition dynamics, secure systems like seL4, hardware exploits like Rowhammer, molecular engineering with AlphaFold, and historical analogies like nuclear arms control. They explore superintelligence governance, multipolar vs singleton futures, and the philosophical challenges of trust, verification, and control in a post-AGI world.

Moderated by Christine Peterson, the discussion seeks the least risky strategy for reaching a preferred state amid superintelligent AI risks. Yudkowsky warns of catastrophic outcomes if AGI is not controlled, while Miller advocates decentralizing power and preserving human institutions as AI evolves.

Continue reading “ASI Risks: Similar premises, opposite conclusions | Eliezer Yudkowsky vs Mark Miller” | >

This Organ Could Reverse Aging! Greg Fahy

If I had the money this would be the first person I would call.

Can one forgotten organ hold the key to reversing aging? In this exclusive interview, Dr. Greg Fahy — one of the world’s leading longevity scientists — reveals groundbreaking discoveries about the thymus, age reversal, and the future of human health.

From regrowing his own thymus to pioneering cryobiology and organ preservation, Dr. Fahy shares insights that could change how we think about aging, immortality, and life extension. This conversation dives into the science behind reversing biological age, restoring the immune system, and even the possibility of medical time travel.

🔑 Topics covered in this video:

Thymus regeneration and why it may be the “master control” of aging.

Continue reading “This Organ Could Reverse Aging! Greg Fahy” | >

New insights into the epigenetic processes via which neuroinflammation causes memory loss

Neuroinflammation, a prolonged activation of the brain’s immune system prompted by infections or other factors, has been linked to the disruption of normal mental functions. Past studies, for instance, have found that neuroinflammation plays a central role in neurodegenerative diseases, medical conditions characterized by the progressive degradation of cells in the spinal cord and brain.

When inflammation is taking place, cells release proteins that act as signals between immune cells, also known as cytokines. While some studies have linked a specific cytokine called interleukin-1 (IL-1) to changes in brain function, the mechanisms through which it could contribute to a decline in mental capabilities remain poorly understood.

Researchers at the University of Toulouse INSERM and CNRS recently carried out a study involving mice aimed at better understanding these mechanisms. Their paper, published in Nature Neuroscience, particularly focused on neuroinflammation elicited by the parasite Toxoplasma gondii (T. gondii), which is responsible for a well-known illness called toxoplasmosis.

Dr. Roman Yampolskiy: These Are The Only 5 Jobs That Will Remain In 2030!

WARNING: AI could end humanity, and we’re completely unprepared. Dr. Roman Yampolskiy reveals how AI will take 99% of jobs, why Sam Altman is ignoring safety, and how we’re heading toward global collapse…or even World War III.

Dr. Roman Yampolskiy is a leading voice in AI safety and a Professor of Computer Science and Engineering. He coined the term “AI safety” in 2010 and has published over 100 papers on the dangers of AI. He is also the author of books such as, ‘Considerations on the AI Endgame: Ethics, Risks and Computational Frameworks’

He explains:
⬛How AI could release a deadly virus.
⬛Why these 5 jobs might be the only ones left.
⬛How superintelligence will dominate humans.
⬛Why ‘superintelligence’ could trigger a global collapse by 2027
⬛How AI could be worse than nuclear weapons.
⬛Why we’re almost certainly living in a simulation.

00:00 Intro.
02:28 How to Stop AI From Killing Everyone.
04:35 What’s the Probability Something Goes Wrong?
04:57 How Long Have You Been Working on AI Safety?
08:15 What Is AI?
09:54 Prediction for 2027
11:38 What Jobs Will Actually Exist?
14:27 Can AI Really Take All Jobs?
18:49 What Happens When All Jobs Are Taken?
20:32 Is There a Good Argument Against AI Replacing Humans?
22:04 Prediction for 2030
23:58 What Happens by 2045?
25:37 Will We Just Find New Careers and Ways to Live?
28:51 Is Anything More Important Than AI Safety Right Now?
30:07 Can’t We Just Unplug It?
31:32 Do We Just Go With It?
37:20 What Is Most Likely to Cause Human Extinction?
39:45 No One Knows What’s Going On Inside AI
41:30 Ads.
42:32 Thoughts on OpenAI and Sam Altman.
46:24 What Will the World Look Like in 2100?
46:56 What Can Be Done About the AI Doom Narrative?
53:55 Should People Be Protesting?
56:10 Are We Living in a Simulation?
1:01:45 How Certain Are You We’re in a Simulation?
1:07:45 Can We Live Forever?
1:12:20 Bitcoin.
1:14:03 What Should I Do Differently After This Conversation?
1:15:07 Are You Religious?
1:17:11 Do These Conversations Make People Feel Good?
1:20:10 What Do Your Strongest Critics Say?
1:21:36 Closing Statements.
1:22:08 If You Had One Button, What Would You Pick?
1:23:36 Are We Moving Toward Mass Unemployment?
1:24:37 Most Important Characteristics.

Follow Dr Roman:
X — https://bit.ly/41C7f70
Google Scholar — https://bit.ly/4gaGE72

You can purchase Dr Roman’s book, ‘Considerations on the AI Endgame: Ethics, Risks and Computational Frameworks’, here: https://amzn.to/4g4Jpa5

Continue reading “Dr. Roman Yampolskiy: These Are The Only 5 Jobs That Will Remain In 2030!” | >

Apertura Gene Therapy and Rett Syndrome Research Trust Collaborate to Pioneer Advanced Genetic Medicines for Rett Syndrome Using TfR1-Targeted AAV Capsid

NEW YORK and TRUMBULL, Conn., April 30, 2025 /PRNewswire/ — Apertura Gene Therapy, a biotechnology company focused on innovative gene therapy solutions, and the Rett Syndrome Research Trust (RSRT), an organization working to cure Rett Syndrome, today announced a collaboration to license Apertura’s human transferrin receptor 1 capsid (TfR1 CapX). This partnership aims to advance innovative genetic medicine approaches for the treatment of Rett Syndrome, a rare genetic neurological disorder caused by random mutations in the MECP2 gene on the X chromosome that primarily affect females, causing developmental regression and severe motor and language impairments.

Apertura’s TfR1 CapX is an intravenously delivered adeno-associated virus (AAV) capsid engineered to bind the transferrin receptor 1(TfR1), enabling efficient delivery of genetic medicines across the blood-brain barrier (BBB). TfR1 is a well-characterized BBB-crossing receptor, broadly and consistently expressed throughout life—even in the context of neurological disease—making it an attractive target for CNS delivery in disorders like Rett syndrome. Developed by Apertura’s academic founder, Dr. Ben Deverman, Director of Vector Engineering at the Broad Institute, TfR1 CapX has shown strong CNS selectivity in preclinical studies, achieving over 50% neuronal and 90% astrocyte transduction across multiple brain regions. Because Rett syndrome affects the brain diffusely, broader cellular transduction may correlate with greater symptomatic improvement.

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