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Category: biotech/medical – Page 3,097

Part 1: Entrepreneur & Researcher Robert Bradbury

This came up recently and it occurred I never posted this here. This is a lecture by Robert Bradbury, not not Ray Bradbury. I had the pleasure of exchanging a few emails with him. Unfortunately those emails are lost so I cannot share them. He was an advocate of life extension and he was a big thinker. I’ll post both vids and a link to the M-brain page. He is not with us anymore I regret to say. Ready?

Renown aging expert Robert Bradbury discusses whole genome engineering, evolution and aging and ways to defeat aging. His talk touches on many areas including nanotechnology, biology, and computer science. More information can be found at http://manhattanbeachproject.com Follow updates at http://twitter.com/maxlifeorg

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Water bears turn into glass when they dry out

Tardigrades — known affectionately as water bears or moss piglets — have pretty much got it all. These microscopic invertebrates are capable of surviving the most extreme conditions you could dream up, including prolonged desiccation and near-100 percent water loss, freezing and boiling temperatures, intense ionising radiation, and the vacuum of outer space.

Scientists have discovered that to survive extreme desiccation, tardigardes produce a special type of ‘bioglass’ to hold essential proteins and molecules together until they’re rehydrated back to life. Now they’re figuring out how to use this mechanism to develop drought-resistant crops and longer-lasting vaccines.

Back in September, researchers from the University of Chicago announced that they’d discovered a new type of glass — one produced internally by the tardigrade during desiccation. While they’re yet to figure out exactly how the glass is formed, they concluded that it’s produced as a protective mechanism to ensure that tardigrades can survive losing pretty much all of the water in their cells.

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The bionic pancreas: harbinger of a new era in organ replacement?

If you haven’t heard of the bionic pancreas, it’s likely you soon will. With diabetes on the rise and the demand for insulin therapies becoming a real pain point for the medical establishment, the need for innovative solutions has spiked. Back in April, we reported on the Do-It-Yourself Pancreas system, a closed-loop artificial pancreas scavenged from a Medtronic pump, Dexcom CGM, a Raspberry Pi, and CareLink USB. Now a fully bionic pancreas similar in design to the Do-It-Yourself model is being developed by doctors at Massachusetts General Hospital and Boston University, with the goal of winning FDA approval. If it succeeds, this will likely be the first bionic organ to see widespread adoption.

Let’s examine some of the previous attempts at bionic organs to see if we can catch a glimpse of where things are heading and some of the societal repercussions that lay in wait. The holy grail of bionic organs is without question the human heart. Coronary artery disease being one of the principal causes of the death worldwide, a fully functioning bionic heart could radically change life expectancy and alter the demographic landscape.

The first bionic hearts, designed over 70 years ago, were plagued by problems that often resulted in thromboembolism and hemorrhage, and made this even more of a gamble than donor transplants. Recent technological advances, however — specifically the advent of bio-prosthetic materials that fool the human immune system into believing the bionic heart is an organic part of the body — could indicate a new era of artificial organs is upon us.

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Forever young: Hydra may hold answers to eternal life

Hydras, simple fresh-water animals, have the ability to live forever if kept in ideal conditions, a recent study shows.

The organisms are made mostly of stem cells that have the ability to continually divide, thus constantly renewing the body.

“The differentiated cells of the tentacles and the foot are constantly being pushed off the body and replaced with new cells migrating from the body column,” Daniel Martinez, a biologist at Pomona College, said in a statement.

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New genes associated with extreme longevity identified

Death is a disease.

Diseases can and will be cured.

Do the math. wink

Disease GWAS show substantial genetic overlap with longevity. Shown are results for coronary artery disease and Alzheimer’s disease. The y axis is the observed P values for longevity, and the x axis is the expected P values under the null hypothesis that the disease is independent of longevity. The cyan, blue and purple lines show the P values for longevity of the top 100, 250, and 500 disease SNPs from independent genetic loci, respectively. Red lines show the background distribution of longevity P values for all independent genetic loci tested in both the longevity and disease GWAS. The grey horizontal line corresponds to the threshold for nominal significance (P = 0.05) for longevity. Significance of enrichment was determined with the hypergeometric test. (credit: Kristen Fortney et al./PLOS Genetics)

What’s the secret of centenarians who have health and diet habits similar to the average person but have remained active and alert at very old ages?

Genes. That’s according to scientists at Stanford University and the University of Bologna, who have written a new report published in PLOS Genetics, based on their finding of several disease variants that may be absent in centenarians compared to the general population.

Continue reading “New genes associated with extreme longevity identified” | >

This Device Lets You Brew Your Own Drugs At Home

A machine prototype called Farma can let you manufacture your daily prescription of drugs right in your own home. Designed by MIT Media Lab graduate Will Patrick, the concept tech features a green cylinder and uses blue-green algae that’s genetically engineered to produce pharmaceutical drugs.

In the future, you might be able to skip the pharmacy and, instead, make your treatments along with your morning breakfast.

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Pulsed laser light turns whole-brain activity on and off

Optogenetic laser light stimulation of the thalamus (credit: Jia Liu et al./eLife)

By flashing high-frequency (40 to 100 pulses per second) optogenetic lasers at the brain’s thalamus, scientists were able to wake up sleeping rats and cause widespread brain activity. In contrast, flashing the laser at 10 pulses per second suppressed the activity of the brain’s sensory cortex and caused rats to enter a seizure-like state of unconsciousness.

“We hope to use this knowledge to develop better treatments for brain injuries and other neurological disorders,” said Jin Hyung Lee, Ph.D., assistant professor of neurology, neurosurgery, and bioengineering at Stanford University, and a senior author of the study, published in the open-access journal eLIFE.

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5 Awesome Inventions That Came out of MIT This Year

We’re coming down the homestretch for 2015, and now is the time when most folks like to reflect on all of the things they’re thankful for. In the campus innovation space, that basically means MIT. Being one of the most technologically progressive universities in the world, MIT has the longstanding reputation of churning out life-changing innovations as if it were a cake walk.

This past year has been no different. Here are our picks of 5 inventions coming out of MIT that are sure to impact the world, making us very thankful to have the Cambridge-based university in our corner.

If everyone’s bodies were true to textbook anatomy, doctors’ jobs would be a breeze. Unfortunately, that’s not the case. So all patients going in for heart surgery will have slightly different nuances to their cardiac makeup. As you can imagine, these procedures present some high stakes, so it’s not great for surgeons to be surprised in the OR.

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Researchers may have discovered fountain of youth

Researchers in Japan have found that human aging may be able to be delayed or even reversed, at least at the most basic level of human cell lines. In the process, the scientists from the University of Tsukuba also found that regulation of two genes is related to how we age.

The new findings challenge one of the current popular theories of aging, that lays the blame for humans’ inevitable downhill slide with mutations that accumulate in our mitochondrial DNA over time. Mitochondrion are sometimes likened to a cellular “furnace” that produces energy through cellular respiration. Damage to the mitochondrial DNA results in changes or mutations in the DNA sequence that build up and are associated with familiar signs of aging like hair loss, osteoporosis and, of course, reduced lifespan.

So goes the theory, at least. But the Tsukuba researchers suggest that something else may be going on within our cells. Their research indicates that the issue may not be that mitochondrial DNA become damaged, but rather that genes get turned “off” or “on” over time. Most intriguing, the team led by Professor Jun-Ichi Hayashi was able to flip the switches on a few genes back to their youthful position, effectively reversing the aging process.

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