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May turn out to be the “fountain-of-youth gene,” say researchers.

An atherosclerotic lesion. Such lesions can rupture and cause heart attacks and strokes. (credit: UVA School of Medicine)

University of Virginia School of Medicine have discovered that a gene called Oct4 — which scientific dogma insists is inactive in adults — actually plays a vital role in preventing ruptured atherosclerotic plaques inside blood vessels, the underlying cause of most heart attacks and strokes.

The researchers found that Oct4 controls the conversion of smooth muscle cells into protective fibrous “caps” inside plaques, making the plaques less likely to rupture. They also discovered that the gene promotes many changes in gene expression that are beneficial in stabilizing the plaques. In addition, the researchers believe it may be possible to develop drugs or other therapeutic agents that target the Oct4 pathway as a way to reduce the incidence of heart attacks or stroke.

Could impact many human diseases, regenerative medicine

The researchers are also currently testing Oct4′s possible role in repairing cellular damage and healing wounds, which would make it useful for regenerative medicine.

Continue reading “Gene helps prevent heart attack, stroke; may also block effects of aging” | >

The visible impacts of depression and stress that can be seen in a person’s face—and contribute to shorter lives—can also be found in alterations in genetic activity, according to newly published research.

In a series of studies involving both C. elegans worms and human cohorts, researchers from the Indiana University School of Medicine and the Scripps Research Institute have identified a series of genes that may modulate the effects of good or bad mood and response to stress on lifespan. In particular, the research pointed to a gene known as ANK3 as playing a key role in affecting . The research was published May 24, 2016 in the Nature Publishing Group journal Molecular Psychiatry, the top ranked journal in the field of psychiatry.

“We were looking for genes that might be at the interface between mood, stress and longevity”, said Alexander B. Niculescu III, M.D., Ph.D., professor of psychiatry and medical neuroscience at the IU School of Medicine. “We have found a series of genes involved in mood disorders and stress disorders which also seem to be involved in longevity.

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(Medical Xpress)—A large team of researchers from a host of research facilities across Japan has found some genetic variants in some cancer cells that lead to enhanced PD-L1 protein production—which results in increased protection against attacks by the immune system. In their paper published in the journal Nature, the team describes their sequencing study involving adult T-cell leukemia/lymphoma cases, what they found and the possibility that such variants could be used as identifying markers in cancer patients.

Prior studies have shown that an increase in the expression of the protein PD-L1 by cancer cells confers enhanced protection against attacks by the human immune system—PD-1 receptors on T cells bind with PD-L1 causing the to become unresponsive, preventing them from attacking tumors. In this new effort, the researchers conducted a genetic analysis of a particular type of cancer cell to learn more about the genetic process involved in causing an increase in expression of PD-L1.

The team conducted whole-genome sequencing on samples given by 49 adult patients suffering from leukemia or lymphoma, looking specifically for variations that might account for an increase in expression of PD-L1. In so doing, they found that variations such as duplications, inversions or translocations in 13 of the samples, representing 27 percent of those tested, existed on a certain part of chromosome 9, which prior research had found was the part of the genome responsible for the expression of PD-L1. They report that such alterations seemed to cut off the gene’s 3’ untranslated region of the protein and in some cases led to rearranging the gene’s open reading frame, which allowed more of the protein to be expressed.

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“The possibility to selectively activate genes using various engineered variants of the CRISPR-Cas9 system left many researchers questioning which of the available synthetic activating Cas9 proteins to use for their purposes. The main challenge was that all had been uniquely designed and tested in different settings; there was no side-by-side comparison of their relative potentials,” said George Church, Ph.D., who is Core Faculty Member at the Wyss Institute for Biologically Inspired Engineering at Harvard University, leader of its Synthetic Biology Platform, and Professor of Genetics at Harvard Medical School. “We wanted to provide that side-by-side comparison to the biomedical research community.”

In a study published on 23 May in Nature Methods, the Wyss Institute team reports how it rigorously compared and ranked the most commonly used artificial Cas9 activators in different cell types from organisms including humans, mice and flies. The findings provide a valuable guide to researchers, allowing them to streamline their endeavors.

The team also included Wyss Core Faculty Member James Collins, Ph.D., who also is the Termeer Professor of Medical Engineering & Science and Professor of Biological Engineering at the Massachusetts Institute of Technology (MIT)’s Department of Biological Engineering and Norbert Perrimon, Ph.D., a Professor of Genetics at Harvard Medical School.

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AR for plastic surgery.

ILLUSIO, the next generation in computer imaging for plastic surgery, will be presenting at the 2016 Virtual Reality Summit in Seoul, South Korea on June 22. The conference is expected to attract thousands of people interested in the latest applications for virtual reality and augmented reality.

ILLUSIO CEO Ethan Winner will present the Company’s use of augmented reality for plastic surgery imaging. ILLUSIO combines the latest in 3D augmented reality technology with real-time morphing animation, providing a platform for plastic surgeons and their patients to visually communicate.

The proprietary artistic adapters and deformers allow surgeons to easily manipulate virtual breast models to quickly replicate any real life breast characteristics. Patients can now see themselves and their future bodies in real time. With the ILLUSIO imaging system, she can turn side-to-side and in real-time see herself with all of the size and shape options that her surgeon creates…

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More information on ANTs.

In the minuscule world of nanotechnology, big steps are rare. But a recent development has the potential to massively improve our lives: an engine measuring 200 billionths of a metre, which could power tiny robots to fight diseases in living cells.

Life itself is proof of the extreme effectiveness of nanotechnology — the manipulation of matter on a molecular or atomic scale — in which DNA, proteins and enzymes can all be considered as machinery. In fact, researchers have managed to make micro-propellers using tiny strands of DNA. These strands can be stitched together so freely and precisely that the practise is known as “DNA origami”. However, DNA origami lacks force and operational speed (it takes time measurable in seconds), reducing its robotic function.

But we have now produced nano-engines that can be operated with beams of light to work pistons, pumps and valves. Made from bound together by a heat-sensitive chemical, our machines are strong, fast and simple to operate, making them extremely practical for future applications.

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US biochemical engineer Frances Arnold on Tuesday won a million-euro technology prize in Finland for her work on “directed evolution”, a method of rewriting DNA to improve medicines and develop green fuels.

“Frances Arnold receives the 2016 Millennium Technology Prize in recognition of her discoveries that launched the field of ‘directed evolution’, which mimics natural evolution to create new and better proteins in the laboratory,” the Technology Academy Finland, which awards the prize at two-year intervals, said in a statement.

Arnold, 59, who is a professor of chemical engineering at California Institute of Technology, said her work made it possible to “solve human problems”, such as replacing toxic chemicals like fossil fuels.

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For the first time ever, scientists were able to successfully cut out the HIV genes from live animals, and they had over a 50% success rate.

A significant milestone was achieved today in the fight against HIV—scientists led by Kamel Khalili of the Comprehensive NeuroAIDS Center at Temple University just reported that, for the first time, HIV genes have been successfully eliminated from the genomes of animals infected with the virus.

“In a proof-of-concept study, we show that our gene editing technology can be effectively delivered to many organs of two small animal models and excise large fragments of viral DNA from the host cell genome,” explained Khalili.

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