Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 2783

Though their use is marred by controversy and debate, stem cells are one of our best bets when it comes to developing regenerative treatments for a plethora of different conditions. Now, scientists believe they’ve found a brand new type of stem cell hidden in plain sight called XEN, also referred to as iXEN, and it could lead to new ways to study birth defects and reproductive problems.

Before we dive into the latest discovery, it’s worth mentioning how researchers have been using stem cells up to this point. Pluripotent stem cells are so important because they have the potential to develop into every cell in the body, effectively allowing researchers to heal any type of tissue. In the past, these cells were harvested from embryos, but researchers have now figured out how to unlock the potential of pluripotent stem cells using adult cells — avoiding the controversy.

These cells are known as induced pluripotent stem cells (iPS) and researchers create them by “reactivating embryonic genes to ‘reprogram’ mature adult cells”. By doing so, researchers can to an extent, control what these cells become, which means they have the power to regrow damaged tissues.

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The project is a joint venture by Russian and South Korean scientists at the Joint Foundation of Molecular Paleontology at North East Russia University in the city of Yakutsk. They will use one of the cubs for the cloning process whilst the other will be kept in a museum.

Remains of two lion cubs were found in Russia’s north-eastern Sakha Republic in August 2015.

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This looks very promising.

The human body is designed pretty well: Our muscles are able to switch between strength and dexterity, limbs stiffening when we do an energy-fueled task like lifting a bowling ball and softening when we do something delicate like painting with a brush. This ability is very rarely replicated in engineering systems, namely because it’s expensive, but also because it’s been damn hard to clone.

However, HRL Laboratories — the same Malibu-based researchers who brought you microlattice — has announced they’ve been able to replicate the reactions of human muscle in metal. Their goal is to use this new technology to create cars with smoother rides and, more intriguingly, more human-like robots.

Continue reading “New Metal Can Become Soft and Stiff Just Like Human Muscles” | >

Using his knowledge of how genes are organized and repaired in human cells, Dr. Graham Dellaire, Dalhousie Medical School’s Cameron Research Scientist in Cancer Biology, has developed a technique that could make gene therapy more effective and safer to use. His work was recently published in Nucleic Acids Research and Nature.

CRISPR, named 2015’s breakthrough discovery of the year, stands for “Clustered Regularly-Interspaced Short Palindromic Repeats.” It can accurately target and edit DNA, offering the potential to cure genetic diseases and find new treatments for cancer.

To apply CRISPR in non-dividing cells—such as those in muscle and brain tissue—researchers must first make them behave like cells that divide. They do this by turning on a cellular process called homologous recombination, which protects DNA; the recombination allows a cell’s genes to be manipulated and rearranged without the possibility of causing more harm than good.

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Veritas Genetics, a Boston-based biotech company co-founded by Harvard geneticist George Church, is claiming it can now sequence your entire genome — the genetic blueprint inside all your cells that makes you who and what you are — for less than $1,000. That price tag includes an interpretation of the results and genetic counseling.

If the claim is true, it would shatter a long-held barrier in genetic medicine.

Reaching the $1,000 genome

The so-called $1,000 genome has long been a holy grail in genetics. While others — notably the company Illumina — have previously claimed to reach this milestone, these efforts did not include the cost of interpreting the results.

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