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Category: biotech/medical – Page 2,694

CRISPR plants: new non-GMO method to edit plants

An NC State researcher has developed a new way to get CRISPR/Cas9 into plant cells without inserting foreign DNA. This allows for precise genetic deletions or replacements, without inserting foreign DNA. Therefore, the end product is not a genetically modified organism, or GMO.

CRISPR/Cas9 is a tool that can be used to precisely cut and remove or replace a specific genetic sequence. The Cas9 serves as a pair of molecular scissors, guided to the specific genetic target by an easily swapped RNA guide. Basically, it seeks out a specific genetic sequence and, when it finds that sequence, cuts it out. Once the target DNA is snipped, it can be deleted or replaced.

The CRISPR/Cas9 system has tremendous potential for improving crops by changing their genetic code. That does not necessarily mean inserting foreign DNA, but the systems used to deliver CRISPR/Cas9 into a plant’s cells often do, which means the relevant crop is a GMOs undergo through a rigorous evaluation process and many consumers prefer non-GMO products.

What Our Post-Pandemic Future Looks Like

The coronavirus pandemic has forced economists, financiers, executives, and policymakers to jettison or dramatically revise their forecasts for 2020. But what will the future look like on the other side of the crisis? We asked a variety of leaders from around the world for their best guess on how our lives will be fundamentally changed.

Economists, investors, and CEOs on how the coronavirus has forever changed the world.

Researchers create durable, washable textile coating that can repel viruses

Masks, gowns, and other personal protective equipment (PPE) are essential for protecting healthcare workers. However, the textiles and materials used in such items can absorb and carry viruses and bacteria, inadvertently spreading the disease the wearer sought to contain.

When the coronavirus spread amongst and left PPE in short supply, finding a way to provide better protection while allowing for the safe reuse of these items became paramount.

Research from the LAMP Lab at the University of Pittsburgh Swanson School of Engineering may have a solution. The lab has created a textile coating that can not only repel liquids like blood and saliva but can also prevent viruses from adhering to the surface. The work was recently published in the journal ACS Applied Materials and Interfaces.

Yes, COVID-toe. A bizarre post-coronavirus symptom causes purple fingers, toes … maybe even ears

On April 7, Karin Shetler awoke in the middle of the night to a toe that was throbbing violently. She threw back the covers to reveal her purple-colored middle toe.

“I wondered whether I had somehow broken my toe,” said Shetler. “I iced it, not understanding what it was, and called my physician sister in New Orleans the next morning.”

She asked if it might be gout. It wasn’t.

Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work

Hypothetical COVID-19 Treatments.

The virus causes clotting everywhere and widespread epithelial damage. One is tempted to treat it like stroke prophylaxis. Patients clot rather than bleed, almost always. The same thing happens in influenza, also.

The pro-clotting effects of corticosteroids may be a reason why they have not stood out yet. The profound anticlotting treatment necessary to treat patients with ECMO extracorporial oxygenation in COVID-19, might have its own therapeutic value (it’s not just the artificial lung but the heparin they need to put you on it!). The lungs of COVID-19 patients in trouble are not only full of fluid, but macro and micro-emboli. Low molecular weight heparin, given in all ICUs, looks like a good gamble.

Aspirin if not contraindicated. Also even Plavix (clopidagrel) for patients with D-dimer showing.

The w-3 fatty acids in fish oil are anti-inflammatory in ways that inhibit clotting, and have been used against shock lung and other inflammatory lung pathologies. Work on COVID-19 is continuing but all are in the hypothetical pipeline.

Drugs which in theory modulate inflammation and clotting in the right direction would be Ca-blockers (particularly verapamil) and ACE-1 inhibitors (particularly lisinopril). The anticlotting antiinflammatory pentoxiphylline (Trental) looks interesting. Trental decreases inflammasomes along with azithromycin (do not exceed recommended dose!), long of interest in COVID-19. Doxycycline and minocycline have specific antiinflammatory activity synergistic with azithromycin.

Continue reading “Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work” | >

Mind-controlled prostheses that “feel” for real

The advance is unique: the patients have used a mind-controlled prosthesis in their everyday life for up to seven years. For the last few years, they have also lived with a new function – sensations of touch in the prosthetic hand. This is a new concept for artificial limbs, which are called neuromusculoskeletal prostheses – as they are connected to the user’s nerves, muscles, and skeleton.

Our weird behavior during the pandemic is messing with AI models

In the week of April 12–18, the top 10 search terms on Amazon.com were: toilet paper, face mask, hand sanitizer, paper towels, Lysol spray, Clorox wipes, mask, Lysol, masks for germ protection, and N95 mask. People weren’t just searching, they were buying too —and in bulk. The majority of people looking for masks ended up buying the new Amazon #1 Best Seller, “Face Mask, Pack of 50”.

When covid-19 hit, we started buying things we’d never bought before. The shift was sudden: the mainstays of Amazon’s top ten—phone cases, phone chargers, Lego—were knocked off the charts in just a few days. Nozzle, a London-based consultancy specializing in algorithmic advertising for Amazon sellers, captured the rapid change in this simple graph.

It took less than a week at the end of February for the top 10 Amazon search terms in multiple countries to fill up with products related to covid-19. You can track the spread of the pandemic by what we shopped for: the items peaked first in Italy, followed by Spain, France, Canada, and the US. The UK and Germany lag slightly behind. “It’s an incredible transition in the space of five days,” says Rael Cline, Nozzle’s CEO. The ripple effects have been seen across retail supply chains.

New weapon identified in arsenal against disease

Scientists at the Kennedy Institute of Rheumatology in the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences have discovered a new way for T cells to attack cells infected by viruses or deranged by cancer.

Published online by the journal Science on Thursday 7 May 2020, the new research from the Dustin Group describes the structure and composition of supramolecular attack particles (SMAPs) and their role in killing targeted .

Cytotoxic T lymphocytes (CTLs) are essential components in the immune response against viruses and cancer. CTLs are known to recognise infected or damaged cells and release soluble protein molecules, which create perforations in the membrane of the targeted cell. These holes allow toxic enzymes to enter and initiate a self-destruct program, killing the targeted cell (cytotoxicity).

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