Lifeboat Foundation

Bone loss and frailty greatly diminish quality of life as we get older, and learning how to regrow bone across the body is a key rejuvenation target.

Stem cells are difficult to work with

We can now produce induced pluripotent stem cells from adult tissue, but differentiating them into a specific tissue is a major challenge. We’re still working on finding the exact chemical cues that create each specific cell type, and stem cells are highly sensitive. There has been progress in many areas, but we still have a way to go.

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A new article on my campaign with a provocative headline, but most of the story is nice. I’ll be speaking in Florida on Saturday as part of the Immortality Bus tour. We visited Alabama’s largest megachurch yesterday:

His name sounds funny to Americans, but presidential candidate Zoltan Istvan says it’s totally normal in Hungary, from where his parents hail. Istvan himself was born in Los Angeles and worked for National Geographic for years — a job that led him to explore science, particularly the concept of transhumanism, which posits that people will merge with technology.

Today, Istvan continues to write for Vice, Psychology Today, Gizmod o, and more — when he’s not campaigning across the country and promoting the Transhumanist Party platform, which promises better lives — and hopefully immortality — through science. Istvan will speak this Saturday at the Church of Perpetual Life in Hollywood, which promotes the same ideals and which New Times featured in a cover story earlier this year.

Continue reading “Presidential Candidate Suggests We Microchip Syrian Refugees” »

It has been hailed as a wonder material set to revolutionise everyday life, but graphene has always been considered too expensive for mass production – until now.

Scientists at Glasgow University have made a breakthrough discovery, allowing graphene to be produced one hundred times more cheaply than before, opening it up to an array of new applications.

First isolated in 2004, the miracle material can be used in almost anything from bendable mobile phone screens to prosthetic skin able to provide sensation.

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Here’s how doctors pulled off the most complicated face transplant ever.

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As many as 20 million Americans have impaired voices because of damage to the vocal cords — more precisely, vocal folds — the researchers report in the journal Science Translational Medicine. There’s no good solution for them now.

Organs for transplant are always in short supply and no one’s really tried transplanting vocal folds into a living patient, the team said. They decided to try growing new ones.

It’s not an easy thing to do. The tissue that makes up vocal folds is extremely specialized. Not just any old tissue will do the job.

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Nanoscale liposomes (orange) containing TRAIL protein (green) attach to the surface of white blood cells (blue), bump into cancer cells (brown), and program them to die (credit: Cornell University)

Cornell biomedical engineers have developed specialized white blood cells they call “super natural killer cells” that seek out cancer cells in lymph nodes with only one purpose: to destroy them, halting the onset of cancer tumor cell metastasis.

“We want to see lymph-node metastasis become a thing of the past,” said Michael R. King, the Daljit S. and Elaine Sarkaria Professor of Biomedical Engineering and senior author of a paper in the journal Biomaterials.

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Each year, an estimated 70 million sharks are killed for their fins. The brutal shark finning process involves cutting off a live shark’s fins and returning the debilitated animal back into the water to die a slow death. Highly valued in traditional Asian medicine and cuisine, the fins can sell for as much as $300 a pound on the black market.

What if an artificial shark fin could remove sharks from the equation completely?

New Wave Foods, a San Francisco-based sustainable seafood company, is developing a bioengineered fin product that could pull the rug out from underneath the shark trade.

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Researchers at the Salk Institute working on an experimental Alzheimer’s drug have discovered it may have a host of anti-aging effects too.

Building on previous work

Research had already been conducted on the drug candidate, J147, with the aim of targeting Alzheimer’s. The results showed the drug could help prevent and even regenerate; reversing memory loss and a form of inherited Alzheimer’s disease in mice subjects. While this form comprises only 1% of Alzheimer’s cases, the biggest risk factor for the remainder is old age. If you could target brain aging itself, risk factors would be significantly reduced.

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Imagine you have a bone fracture or a hip replacement, and you need bone to form, but you heal slowly – a common fact of life for older people. Instead of forming bone, you could form fat. Researchers at the University of North Carolina School of Medicine may have found a way to tip the scale in favor of bone formation. They used cytochalasin D, a naturally occurring substance found in mold, as a proxy to alter gene expression in the nuclei of mesenchymal stem cells to force them to become osteoblasts (bone cells).

By treating stem cells – which can become fat or bone cells — with cytochalasin D– the result was clear: the stem cells became bone cells. Further, injecting a small amount of cytochalasin D into the bone marrow space of mice caused bone to form. This research, published in the journal Stem Cells, details how the scientists altered the stem cells and triggered bone growth.

“And the bone forms quickly,” said Janet Rubin, MD, senior author of the paper and professor of medicine at the UNC School of Medicine. “The data and images are so clear; you don’t have to be a bone biologist to see what cytochalasin D does in one week in a mouse.”

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