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3D Map of the cell-building protein tied to cancer.


The unprecedented view of the protein doublecortin kinase like domain 1 (DCLK1) could provide clues to how it contributes to cancer formation and progression.

DCLK1 is a protein that assembles scaffolds within cells called microtubules. These rope-like structures give cells shape, enable movement and cell division, and are crucial in enabling the growth and spread of cancer cells. More than one in 10 stomach cancers have defective forms of DCLK1, which have also been found in kidney, rectal and pancreatic cancers.

Walter and Eliza Hall Institute scientists Dr Onisha Patel and Dr Isabelle Lucet used the Australian Synchrotron to reveal the three-dimensional structure of a part of DCLK1 known as the ‘kinase domain’.

We are entering an era of directed design in which we will expand the limited notion that biology is only the ‘study of life and living things’ and see biology as the ultimate distributed, manufacturing platform (as Stanford bioengineer, Drew Endy, often says). This new mode of manufacturing will offer us unrivaled personalization and functionality.

New foods. New fuels. New materials. New drugs.

We’re already taking our first steps in this direction. Joule Unlimited has engineered bacteria to convert CO2 into fuels in a single-step, continuous process. Others are engineering yeast to produce artemisinin — a potent anti-malarial compound used by millions of people globally. Still other microbes are being reprogrammed to produce industrial ingredients, like those used in synthetic rubber.

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Hmmmm.


Technocrat scientists believe they can ‘code’ any kind of future they want, but what about what everyone else wants? These are the overlords of Technocracy who believe that we should just ‘trust them’ to build Utopia. ⁃ TN Editor.

Imagine a future where there is no need to cut down a tree and reshape that raw material into a chair or table. Instead, we could grow our furniture by custom-engineering moss or mushrooms. Perhaps glowing bacteria will light our cities, and we’ll be able to bring back extinct species, or wipe out Lyme disease — or maybe even terraform Mars. Synthetic biology could help us accomplish all that.

Interesting research paper on motor cortex-based brain-computer interface (BCI) research conducted by researchers from UW. Sharing with fellow partners and researchers trying to advance BMI as well as those researching and/ or re-creating brain/ neuro patterns in systems.


The neurons in the human brain are densely interlaced, sharing upwards of 100 trillion physical connections. It is widely theorized that this tremendous connectivity is one of the facets of our nervous system that enables human intelligence. In this study, over the course of a week, human subjects learned to use electrical activity recorded directly from the surface of their brain to control a computer cursor. This provided us an opportunity to investigate patterns of interactivity that occur in the brain during the development of a new skill. We demonstrated two fundamentally different forms of interactions, one spanning only neighboring populations of neurons and the other covering much longer distances across the brain. The short-distance interaction type was notably stronger during early phases of learning, lessening with time, whereas the other was not. These findings point to evidence of multiple different forms of task-relevant communication taking place between regions in the human brain, and serve as a building block in our efforts to better understand human intelligence.

Citation: Wander JD, Sarma D, Johnson LA, Fetz EE, Rao RPN, Ojemann JG, et al. (2016) Cortico-Cortical Interactions during Acquisition and Use of a Neuroprosthetic Skill. PLoS Comput Biol 12: e1004931. doi:10.1371/journal.pcbi.1004931

Editor: Olaf Sporns, Indiana University, UNITED STATES

Luv this.


Smart devices implanted in the body have thus far not been able to communicate via Wi-Fi due to the power requirements of such communications. Surgery is required when the battery in a brain stimulator or a pacemaker needs to be replaced. Not only is this expensive, but any surgery has inherent risks and could lead to complications. It is therefore critically important that the battery life in implanted medical devices be preserved for as long as possible.

Other constraints limiting how much power a device can use include their location in the body and their size. New emerging devices that could one day reanimate limbs, stimulate organs, or brain implants that treat Parkinson’s disease are limited by the same factors.

SENS RB2016 Conference is now live streaming come along and join them now and get the latest news! They are streaming for the next 3 days for those interesting in rejuvenation biotechnology.


All presentations at the Rejuvenation Biotechnology Conference 2016 will be available to watch online via live streaming. There will be three separate streams, covering consecutive sections of the conference.

To access the streams bookmark the following links and tune in during the times specified:

Imagine this scenario: Annual physical examinations are supplemented by an affordable home diagnostic chip, allowing you to regularly monitor your baseline health with just a simple urine sample. Though outwardly you appear to be in good health, the device reveals a fluctuation in your biomarker profile, indicating the possible emergence of early stage cancer development or presence of a virus.

Diagnostic devices like a home pregnancy test have been around since the 1970s. It revolutionized a woman’s ability to find out if she was pregnant without having to wait for a doctor’s appointment to confirm her suspicions. The test relies on detecting a hormone, human chorionic gonadotropin, present in urine. But could detecting cancer, or a deadly virus, from a similar kind of sample and device be as simple and non-invasive?

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