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Shortened telomeres, the protective caps at the ends of chromosomes (credit: NIGMS)

Scientists at Emory University School of Medicine have found that the dietary supplement alpha lipoic acid (ALA) can stimulate telomerase, the enzyme that lengthens telomeres, with positive effects in a mouse model of atherosclerosis.

In human cells, shortened telomeres, the protective caps at the ends of chromosomes, are a sign of aging and also contribute to aging.

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Major advancement in Gene Editing.


A team involving Kobe University researchers has succeeded in developing ‘Target-AID’, a genome editing technique that does not cleave the DNA. The technique offers, through high-level editing operation, a method to address the existing issues of genome editing. It is expected that the technique will be applied to gene therapy in the future in addition to providing a powerful tool for breeding useful organisms and conducting disease and drug-discovery research. The findings were published online in Science on August 5.

The team consists of Project Associate Professor NISHIDA Keiji and Professor KONDO Akihiko (Graduate School of Science, Technology and Innovation, Kobe University) as well as Associate Professor YACHIE Nozomu (Synthetic Biology Division, Research Center for Advanced Science and Technology, the University of Tokyo) and Professor HARA Kiyotaka (Department of Environmental Sciences, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka).

Genome editing — which can directly manipulate the genome information of various organisms without leaving an artificial strand — has seen rapid progress in recent years and it is gradually becoming a revolutionary tool in fields ranging from life sciences to advanced medical research.

It echoes the nanite and nanobot technology seen in science fiction TV series like Star Trek and Red Dwarf, where swarms of microscopic robots can be used to repair damaged tissue.

Researchers at Bar Ilan University in Ramat Gan, Israel, and the Interdisciplinary Centre in Herzliya, built their nanobots using a form to DNA origami to create hollow shell-like structures.

Drugs could then be placed inside these before they were chemically locked shut with particles of iron oxide.

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To help stem the tide of rhino poaching, some biotech companies such as Pembient are seeking to develop and manufacture synthetic horns that are biologically identical to the real thing. The thinking behind this is that the availability of bio-identical fake horns at a substantially lower price than wild horns would cause demand to shift towards the synthetic substitutes, which would reduce people’s incentives to poach rhinos.

I have argued previously that—from the perspective of what would be most effective in curbing poaching—the synthetic horns should not be made to be perfect fakes, i.e., bio-identical. Instead, the synthetic horns should be engineered to be (i) difficult to distinguish from wild horns but (ii) undesirable or unappealing in some respect so that buyers would place little value on them. This proposal makes use of a phenomenon in economics known as adverse selection, which occurs when buyers in a market are unable to distinguish between high- and low-quality products, and their lack of information drives down demand—and, hence, prices—enough that high-quality products (which would be wild horns in the context of rhino horns) cease to be supplied by sellers.

For conservationists and others who are concerned about the fate of the rhinos, it is critical to understand why biotech companies would prefer making bio-identical synthetic horns—rather than undesirable fakes—because of the implications this has for conservation policies. Simply put, it would be more profitable to produce and sell perfect fakes rather than synthetic horns that would be considered undesirable. All else being equal, putting out undesirable fakes that buyers cannot distinguish from the real ones, by reducing demand for horns, would lead to lower prices in the horn market compared to the case with bio-identical synthetic horns. This, of course, would generate less revenue for the producers of synthetic horns.

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Check it out! Finally! Now get ready to mass produce synthetic diamonds for QC, medical tech, etc.


Every additive manufacturing (AM) system offers the potential for endless creativity. As designers learn to embrace the possibilities offered by digital design and AM, the number of applications for the technology increases. Everything has its limits, however, and for AM those limits are sometimes related to materials.

3D printing has already come a long way from the days when it was primarily a plastic process. You can find AM systems that print in wood, ceramics, metal and much, much more. According to a patent filed with the US Patent & Trademark Office, Lockheed Martin may be developing a method that will add synthetic diamond to that list.

Biology is the world’s greatest manufacturing platform, according to MIT spinout Ginkgo Bioworks.

The synthetic-biology startup is re-engineering yeast to act as tiny organic “factories” that produce chemicals for the flavor, fragrance, and food industries, with aims of making products more quickly, cheaply, and efficiently than traditional methods.

“We see biology as a transformative technology,” says Ginkgo co-founder Reshma Shetty PhD ’08, who co-invented the technology at MIT. “It is the most powerful and sophisticated manufacturing platform on the planet, able to self-assemble incredible structures at a scale that is far out of reach of the most cutting-edge human technology.”

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