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A neural circuit mechanism involved in preserving the specificity of memories has been identified by investigators from the Massachusetts General Hospital (MGH) Center for Regenerative Medicine and the Harvard Stem Cell Institute (HSCI).

They also identified a genetic “switch” that can slow down #memory generalization — the loss of specific details over time that occurs in both age-related memory impairment and in post-traumatic stress disorder (#PTSD), in which emotions originally produced by traumatic experiences are elicited in response to innocuous cues that have little resemblance to the traumatic memory.

“The circuit mechanism we identified in mice allows us to preserve the precision or the details of memories over the passage of time in adult as well as aged animals,” says Amar Sahay of the MGH Center for #Regenerative Medicine and HSCI, corresponding author of a paper appearing in Nature Medicine. “These findings have implications for the generalization of traumatic memories in PTSD and for memory imprecision in #aging.”

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D rugs to vaccinate everyone over the age of 50 against Alzheimer’s could be available within 10 years, but would cost the NHS £9 billion, a new report has shown.

New analysis commissioned by Alzheimer’s Research UK found that drugs to halt, slow or reverse the disease could be available in as little as three years with major vaccine and screening programmes possible within a decade.

But dementia experts warned that demand from patients would be ‘instant and huge’ and called on the NHS to act now to make sure funds were in place for when the breakthroughs occurred.

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Cancer remains the one counterpoint to the march of medical progress that has scored human history over the last 200 years.

Last year 600,920 people in the U.S. died from cancer, and another 1.7 million received an initial diagnosis of the disease. Globally, one in six people die from cancer, according to the World Health Organization.

In the past decade, research in the field has expanded the possible treatments of the disease from surgery (which was the only option until the 20th century), radiotherapy, chemotherapy and hormonal therapy.

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I would like to share a story. A story about sadness, depression, anger, and frustration. But most of all this is my personal story about triumphing over the death sentence of #cancer. I hope this story will give others who went through and are going through hope for the future.

My story started about 4 years ago on a cold winter day. Up until this point my life seemed invincible. That all changed. At the time I was working at the plasma center and we were preparing for an audit by the FDA. Before an audit we would have the floors waxed and make the center look as nice as possible. A few co-workers and I stayed late to help move the donor beds. I knew I had been feeling pain in my neck/shoulder area for a few weeks so I really didn’t want to. I figured it must have been from repetitive motions at work. I decided to just ignore it and help anyways: this decision changed my life dramatically.

As my coworker and I lifted a donor bed I felt a sharp pain in my neck. I could barely move my arm as it was so excruciating. I couldn’t lift my arm to my chest. I shyly let my manager know that I hurt myself. My manager had me go to Concentra #Health since I was going to be covered under worker’s compensation there. It was there I met Dr. Kreiger, one of the doctors who helped save my life.

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An interview with Komsomolskaya Pravda during the conference Undoing Aging in Berlin.


A few days ago, LEAF representatives attended the Undoing Aging 2018 conference in Berlin, which was jointly organized by the SENS Research Foundation and the Forever Healthy Foundation. We invited one of the most professional Russian journalists writing about aging, Anna Dobryukha, to this conference, and she will write a series of articles and interviews in Komsomolskaya Pravda (KP) over the next weeks. As these articles are interesting to the global community, we decided to translate them for our blog.

Today, we publish the first article of this series, an interview that Anna conducted with Vitalik Buterin, the creator of the cryptocurrency Ethereum. Vitalik donated 2.4 million dollars to the SENS Research Foundation earlier this year, so let’s find out what Vitalik’s views are on rejuvenation biotech and life extension!

The original article, “King of Ethereum” Vitalik Buterin: the best thing to donate money to is the fight against aging, is by Anna Dobryukha and has been translated by Elena Milova and Joshua Conway.

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March 19 (UPI) — Researchers in California have developed a retinal patch with stem cells to improve the vision of people with age-related macular degeneration.

In a clinical trial, researchers at the University of California Santa Barbara implanted the stem cell-derived ocular cells in two patients over the course of 12 months, publishing the results of the study Monday in the journal in Nature Biotechnology.

Macular degeneration, which affects the central, or reading, vision while leaving the surrounding vision normal, usually affects people over 50 years of age. The Centers for Disease Control and Prevention estimates that 1.8 million Americans aged 40 years and older have AMD, and it’s the leading cause of permanent impairment of close-up vision among people aged 65 years and older.

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G iving all men with suspected prostate cancer an immediate MRI scan would save thousands of lives a year, the results of a new study suggest.

A trial by British scientists found the comprehensive scan was 12 per cent more likely to detect dangerous tumours than the traditional biopsy, and that the number of men who undergo a biopsy needlessly could be reduced by 28 per cent.

Every year more than 120,000 men in the UK undergo a biopsy, which involves inserting an ultrasound probe into the affected area to take a sample of cells from the prostate that might contain cancer.

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