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Just when you thought there wasnt mushroom left for new drug discovery!


A team of Michigan State University scientists has genetically sequenced two species of poisonous mushrooms, discovering that they can theoretically produce billions of compounds through one molecular assembly line. This may open the door to efficiently tackling some lethal diseases.

The study, published in the journal BMC Genomics, reveals the DNA of two Amanita mushrooms, which are responsible for the majority of fatal mushroom poisonings.

The team will focus on the “Death Cap,” which grows all over the West Coast and Europe, and the “Destroying Angel,” native to Michigan.

Scientists have engineered the first ever ‘semi-synthetic’ organisms, by breeding E. coli bacteria with an expanded, six-letter genetic code.

While every living thing on Earth is formed according to a DNA code made up of four bases (represented by the letters G, T, C and A), these modified E. coli carry an entirely new type of DNA, with two additional DNA bases, X and Y, nestled in their genetic code.

The team, led by Floyd Romesberg from the Scripps Research Institute in California, engineered synthetic nucleotides — molecules that serve as the building blocks of DNA and RNA — to create an additional base pair, and they’ve successfully inserted this into the E. coli’s genetic code.

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Back in September, the Chan Zuckerberg Initiative – the philanthropic company set up by Facebook CEO Mark Zuckerberg and his wife, Dr. Priscilla Chan – set a goal to invest $3 billion to cure, prevent, and manage disease by the end of the century.

The company has taken a huge first step toward the objective by partnering with scientists, doctors, engineers, and other key stakeholders. With the acquisition of Toronto-based company, Meta, the team is moving even closer to their goal by creating tools and technology designed to empower the scientific community.

Meta is a research paper search engine that uses artificial intelligence (AI) to deliver the most relevant results to researchers. Following this acquisition, the Chan Zuckerberg initiative will enhance the service before eventually rolling it out for free.

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Science isn’t the easiest thing to understand especially biology, but are we getting the message right about rejuvenation biotechnology? Reason at Fight aging delves into the issues and offers commentary about our recent blog article at LEAF.


For those of us who immediately understand, at first recognition, that the opportunity to live a longer life in good health would be a fantastic thing, and in fact so wondrous that we should jump up and do something to make it happen, it is a continual puzzle that we find ourselves in a minority. How is it that we live in a world in which the majority simply doesn’t care, or if prompted on the topic, declares their desire to age, suffer, and die on the present schedule? After a few years of this, one might be forgiven for thinking that we are just not very good at advocacy. But given a second consideration, we might ask why we should have to be good at advocacy at all in this situation. Isn’t more good health and vigor, and an absence of horrible, debilitating age-related disease, an obvious and unalloyed good? Isn’t the whole point of medicine to defeat disease and prolong health? Isn’t it the case that all of these people in favor of aging and age-related death nonetheless go out and visit the doctor when they get ill, while supporting research into treatments for cancer and other age-related diseases? I don’t think that we are the irrational ones in this picture.

After going on fifteen years of writing on this topic, I don’t have much more of an idea than I did when I started as to why greater human longevity isn’t an obvious and highly important goal for everyone. The same questions and theories back then are still here today, and there is still little data to pin down their accuracy: fear of frailty, of overpopulation, of any change, even positive, and so forth. Since it was an immediate and evident revelation for me, rather than a gradual conversion, perhaps I am not the right person to achieve that understanding. I am, however, pleased to see that despite the challenges our community of iconoclasts, heretics, revolutionaries, and rational thinkers on the subject of longevity science is greatly expanded these days. More of these folk than ever are writing and persuading, both inside and outside the scientific community. We have progressed and grown as a community, alongside progress in the state of the science.

For today, I see that the Life Extension Advocacy Foundation has set up a blog in order to help bring spread our message to new audiences. As noted by the author here, the best evidence so far suggests that the fear of being old and decrepit for longer as a result of life extension therapies is the most important factor in public opposition to greater longevity, despite the fact that scientists and advocates have repeatedly disclaimed this as a goal, and that many have noted that such an outcome is implausible to achieve even if someone was trying. On the one hand that suggests that it is simple ignorance that might be dispelled, but on the other it seems very resistant to the efforts already made, over and again, by near every public figure involved in the aging research community.

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Fighting cancer with lasers.


In an effort to eliminate the side effects of modern cancer treatments, Dr. Hadiyah-Nicole Green began exploring the use of light-activated nanoparticles to target tumors directly. #HistoryNOW

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History NOW is a collection of timely and relevant stories that can only be experienced, documented, and shared right now. Throughout 2016, History NOW will feature powerful videos from people capturing significant, transformative events from their unique first-person perspectives. From politics and sports to science and technology, these are the people making history now.

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Technology giant IBM is known for of making bold predictions about the future, and it’s just announced its latest “5 in 5” list, highlighting the five innovations that they think will have the biggest impact on our lives over the next five years.

According to the company, in only a few years, we’re set to see huge developments in artificial intelligence (AI), ultra-powerful telescopes, smart sensors, and medical devices — with benefits ranging from healthcare and the environment, to our understanding of Earth and the Universe itself.

Of course, all these predictions are based on technology and research developments that are happening right now — there’s no way of knowing what else might crop up in the next five years.

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