A new study suggests that NAD+, which declines with age, may be increased via the de novo pathway.
Read more
Category: biotech/medical – Page 2,514
Research has discovered that inside every cell in the human body is a kill code designed to trigger self-destruction if it senses a cell is turning cancerous. Across two studies the scientists homed in on the code underlying this mechanism and believe it may lead to a new kind of cancer treatment.
Read more
If you haven’t heard, universities around the world are offering their courses online for free (or at least partially free). These courses are collectively called MOOCs or Massive Open Online Courses.
In the past six years or so, over 800 universities have created more than 10,000 of these MOOCs. And I’ve been keeping track of these MOOCs the entire time over at Class Central, ever since they rose to prominence.
In the past four months alone, 190 universities have announced 600 such free online courses. I’ve compiled a list of them and categorized them according to the following subjects: Computer Science, Mathematics, Programming, Data Science, Humanities, Social Sciences, Education & Teaching, Health & Medicine, Business, Personal Development, Engineering, Art & Design, and finally Science.
Read more
I have always said the trick with being diagnosed with cancer is living long enough to see newer and better therapies coming out to help you outlive your own diagnosis:
Scientists at Northwestern University have discovered a “kill code” in every cell of the body that’s triggered by chemotherapy and that causes cancerous cells to self-destruct. What’s more, they’ve learned enough about the code that they’ve figured out how to trigger it without chemo—a finding that they believe could lead to new therapies.
The discovery, reported in the journals Nature Communications and eLife, is a code that’s found in both large and small ribonucleic acids (RNAs). The researchers also have early evidence that the small RNAs, called microRNAs, can be introduced into cells to trigger the kill switch.
“My goal was not to come up with a new artificial toxic substance,” said lead author Marcus Peter, Ph.D., a professor of cancer metabolism at Northwestern’s Feinberg School of Medicine, in a statement. “I wanted to follow nature’s lead. I want to utilize a mechanism that nature developed.”
Read more
The October Journal Club will be focusing on a new study in worms where a combination of compounds acted in synergy to almost double lifespan.
SUMMARY There is growing interest in pharmacological interventions directly targeting the aging process. Pharmacological interventions against aging should be efficacious when started in adults and, ideally, repurpose existing drugs. We show that dramatic lifespan extension can be achieved by targeting multiple, evolutionarily conserved aging pathways and mechanisms using drug combinations. Using this approach in C. elegans, we were able to slow aging and significantly extend healthy lifespan. To identify the mechanism of these drug synergies, we applied transcriptomics and lipidomics analysis. We found that drug interactions involved the TGF-b pathway and recruited genes related with IGF signaling. daf-2, daf-7, and sbp-1 interact upstream of changes in lipid metabolism, resulting in increased monounsaturated fatty acid content and this is required for healthy lifespan extension. These data suggest that combinations of drugs targeting distinct subsets of the aging gene regulatory network can be leveraged to cause synergistic lifespan benefits.
Read more
Evidence has been building in recent years that our diet, our habits or traumatic experiences can have consequences for the health of our children — and even our grandchildren. The explanation that has gained most currency for how this occurs is so-called ‘epigenetic inheritance’ — patterns of chemical ‘marks’ on or around our DNA that are hypothesised to be passed down the generations. But new research from the University of Cambridge suggests that this mechanism of non-genetic inheritance is likely to be very rare.
A second study, also from Cambridge, suggests, however, that one way that environmental effects are passed on may in fact be through molecules produced from the DNA known as RNA that are found in a father’s sperm.
The mechanism by which we inherit innate characteristics from our parents is well understood: we inherit half of our genes from our mother and half from our father. However, the mechanism whereby a ‘memory’ of the parent’s environment and behaviour might be passed down through the generations is not understood.
Read more
The FDA has recently given 510(k) clearance to the OpenSight Augmented Reality System, the first augmented reality (AR) medical solution for Microsoft HoloLens cleared for use in pre-operative surgical planning.
The technology projects 2D, 3D and 4D images of patients interactively by overlaying them onto the patient’s body, according to a Novarad press release published Oct. 24.
OpenSight specifically utilizes the Microsoft HoloLens headset that allows simultaneous visualization of the 3D patient images in AR and the actual patient and their real-world surroundings. The technique may decrease operative times and improve surgical planning and the understanding of anatomic relationships.
Read more
