Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 2,506

Aging may seem like the most natural—and inevitable—thing in life. Yet according to a new study in Nature Medicine, rejuvenating an aging body may be as easy as kitchen renovations. Simply swap drill and hammer for a cocktail of two drugs already on the market; rather than pulling out decrepit cabinets, kill off aged “zombie” cells.

These so-called senescent cells are a curious oddity: they’re frail, beat-up, and unable to perform their usual roles. Yet they simply refuse to die. What’s more, zombie cells actively leak inflammatory chemicals into their surroundings, damaging nearby tissue and—in a sense—“spreading” the negative effects of aging.

Yet because they’re extremely rare, amounting to only eight percent of the body’s cells at most, scientists have long wondered just how much they contribute to the aging process.

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About the future death of explainability to understand AI thinking, the writing is on the wall…

These divergent approaches, one regulatory, the other deregulatory, follow the same pattern as antitrust enforcement, which faded in Washington and began flourishing in Brussels during the George W. Bush administration. But there is a convincing case that when it comes to overseeing the use and abuse of algorithms, neither the European nor the American approach has much to offer. Automated decision-making has revolutionized many sectors of the economy and it brings real gains to society. It also threatens privacy, autonomy, democratic practice, and ideals of social equality in ways we are only beginning to appreciate.

At the simplest level, an algorithm is a sequence of steps for solving a problem. The instructions for using a coffeemaker are an algorithm for converting inputs (grounds, filter, water) into an output (coffee). When people say they’re worried about the power of algorithms, however, they’re talking about the application of sophisticated, often opaque, software programs to enormous data sets. These programs employ advanced statistical methods and machine-learning techniques to pick out patterns and correlations, which they use to make predictions. The most advanced among them, including a subclass of machine-learning algorithms called “deep neural networks,” can infer complex, nonlinear relationships that they weren’t specifically programmed to find.

Predictive algorithms are increasingly central to our lives. They determine everything from what ads we see on the Internet, to whether we are flagged for increased security screening at the airport, to our medical diagnoses and credit scores. They lie behind two of the most powerful products of the digital information age: Google Search and Facebook’s Newsfeed. In many respects, machine-learning algorithms are a boon to humanity; they can map epidemics, reduce energy consumption, perform speech recognition, and predict what shows you might like on Netflix. In other respects, they are troubling. Facebook uses AI algorithms to discern the mental and emotional states of its users. While Mark Zuckerberg emphasizes the application of this technique to suicide prevention, opportunities for optimizing advertising may provide the stronger commercial incentive.

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The Casimir force and superconductivity are two well-known quantum effects. These phenomena have been thoroughly studied separately, but what happens when these effects are combined in a single experiment? Now, Delft University of Technology have created a microchip on which two wires were placed in close proximity in order to measure the Casimir forces that act upon them when they become superconducting.

Is vacuum really empty? Quantum mechanics tells us that it’s actually swarming with particles. In the 1940s, Dutch physicists Hendrik Casimir and Dirk Polder predicted that when two objects are placed in very close proximity, about a thousandth of the diameter of a human hair, this sea of ‘vacuum particles’ pushes them together – a phenomenon known as the Casimir effect. This attractive force is present between all objects and even sets fundamental limits to how closely we can place components together on microchips.

Superconductivity is another well-known phenomenon, also discovered by a Dutchman, Heike Kamerlingh Onnes, in the early 20th century. It describes how certain materials, such as aluminum or lead, allow electricity to flow through them without any resistance at . Over the last 100 years, superconductors have revolutionized our understanding of physics and are responsible for magnetically levitated trains, MRI scans and even mobile phone stations.

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Aging may be regulated by a discrete set of intracellular proteins including the mechanistic target of rapamycin (mTOR) kinase. mTOR functions within two multiprotein complexes called TORC1 and TORC2. Inhibition of TORC1 has extended life span in every species studied to date and ameliorated multiple aging-related pathologies including declining immune function. Mannick et al. now show that low-dose TORC1 inhibitor therapy in elderly humans decreased the incidence of all infections, improved influenza vaccination responses, and up-regulated antiviral immunity. Thus, targeting the TORC1 pathway that regulates aging may have clinical benefits for elderly humans including improvement in immune function and decreased infection rates.

Inhibition of the mechanistic target of rapamycin (mTOR) protein kinase extends life span and ameliorates aging-related pathologies including declining immune function in model organisms. The objective of this phase 2a randomized, placebo-controlled clinical trial was to determine whether low-dose mTOR inhibitor therapy enhanced immune function and decreased infection rates in 264 elderly subjects given the study drugs for 6 weeks. A low-dose combination of a catalytic (BEZ235) plus an allosteric (RAD001) mTOR inhibitor that selectively inhibits target of rapamycin complex 1 (TORC1) downstream of mTOR was safe and was associated with a significant (P = 0.001) decrease in the rate of infections reported by elderly subjects for a year after study drug initiation. In addition, we observed an up-regulation of antiviral gene expression and an improvement in the response to influenza vaccination in this treatment group.

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The latest robots out of MIT are small enough to float “indefinitely” in the air. Researchers accomplished the feat by attaching 2D electronics to colloids — tiny particles measuring around one-billionth to one-millionth of a meter. All told, the devices are roughly the size of a human egg cell.

What’s more, the addition of photodiode semiconductors means the tiny individual systems are able to be self-powered, without the need for a battery. The system converts light into a small electrical charge that’s enough to keep the device’s on-board environmental sensors running, while storing on-board information.

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Australian researchers have made a discovery about telomeres that may have implications for aging, heart disease, cancer, and other age-related diseases.

So, what are telomeres?

Each of the chromosomes that store our genetic information has a telomere at each end. This protective cap consists of a specific DNA sequence that is repeated thousands of times and has two purposes: firstly, it protects the coding regions of the chromosomes and prevents them from being damaged, and secondly, it acts as a clock that controls the number of replications a cell can undergo; this is thought to act as a quality control system to ensure that aged and potentially damaged cells do not remain in circulation.

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I’m excited to share I’ll be speaking/debating at the upcoming #Biohack the Planet 2018 conference in Oakland on Aug 31 & Sept 1. Many interesting biohackers will be there. Tickets are still available and very reasonably priced right now, but they will likely sell out. Hope to see you there! Here’s the speaker list: http://biohacktheplanet.com/2018-speakers/ #transhumanism #biohacker & ticket page: https://www.eventbrite.com/e/biohack-the-planet-2018-ticket…

Bryan Johnson is the founder and CEO of Kernel, OS Fund and Braintree.

In 2016, Bryan invested $100M in Kernel to build advanced neural interfaces to treat disease and dysfunction, illuminate the mechanisms of intelligence, and extend cognition. Kernel is on a mission to dramatically increase our quality of life as healthy lifespans extend. He believes that the future of humanity will be defined by the combination of human and artificial intelligence (HI +AI). In 2014, Bryan invested $100M to start OS Fund which invests in entrepreneurs commercializing breakthrough discoveries in genomics, synthetic biology, artificial intelligence, precision automation, and new materials development. Bryan founded Braintree in 2007, later acquiring Venmo, which he sold to Ebay in 2013 for $800M. He is an outdoor-adventure enthusiast, pilot, and author of a children’s book, Code 7.

Michael Specter is a staff writer at The New Yorker.

Since joining the magazine in 1998, he has written about agricultural biotechnology, the global AIDS epidemic, avian influenza, malaria, the world’s diminishing freshwater resources, synthetic biology, geoengineering, new ways to edit DNA with CRISPR, and the implications of gene drive technology. His profile subjects include: Ingrid Newkirk, the founder of PETA, Dr. Oz, Peter Singer, Vandana Shiva, Miuccia Prada, and Richard Branson. Specter came to The New Yorker from the New York Times, where he had been a roving foreign correspondent based in Rome. From 1995 to 1998, Specter served as co-chief of The Times Moscow bureau. Before working at the Times he was the New York Bureau Chief of The Washington Post.

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BIRMINGHAM, Ala. — Wrinkled skin and hair loss are hallmarks of aging. What if they could be reversed?

Keshav Singh, Ph.D., and colleagues have done just that, in a mouse model developed at the University of Alabama at Birmingham. When a mutation leading to mitochondrial dysfunction is induced, the mouse develops wrinkled skin and extensive, visible hair loss in a matter of weeks. When the mitochondrial function is restored by turning off the gene responsible for mitochondrial dysfunction, the mouse returns to smooth skin and thick fur, indistinguishable from a healthy mouse of the same age.

“To our knowledge, this observation is unprecedented,” said Singh, a professor of genetics in the UAB School of Medicine.

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