In the United States – the world’s biggest and most advanced pharmaceutical market – of the 46 new drugs given consent for marketing by regulators last year, 28 were developed by US firms and the realisation of all but four of the rest were led by European firms. None were Chinese.
China’s big ambitions to become a powerhouse of pharmaceutical innovation is as much about the well-being of its people as it is about narrowing the gap with the West.
Optical frequency combs can enable ultrafast processes in physics, biology, and chemistry, as well as improve communication and navigation, medical testing, and security. The Nobel Prize in Physics 2005 was awarded to the developers of laser-based precision spectroscopy, including the optical frequency comb technique, and microresonator combs have become an intense focus of research over the past decade.
A major challenge has been how to make such comb sources smaller and more robust and portable. In the past 10 years, major advances have been made in the use of monolithic, chip-based microresonators to produce such combs. While the microresonators generating the frequency combs are tiny—smaller than a human hair—they have always relied on external lasers that are often much larger, expensive, and power-hungry.
Researchers at Columbia Engineering announced today in Nature that they have built a Kerr frequency comb generator that, for the first time, integrates the laser together with the microresonator, significantly shrinking the system’s size and power requirements. They designed the laser so that half of the laser cavity is based on a semiconductor waveguide section with high optical gain, while the other half is based on waveguides, made of silicon nitride, a very low-loss material. Their results showed that they no longer need to connect separate devices in the lab using fiber—they can now integrate it all on photonic chips that are compact and energy efficient.
Today, we are going to be taking a look at GAIM and what it might mean for treating amyloid-based diseases, such as Alzheimer’s, Parkinson’s, and amyloidosis. This approach has the potential to treat multiple age-related diseases at once by targeting a common characteristic that they all share.
Misfolded proteins cause multiple age-related diseases
Proteins are large, complex molecules that regulate almost everything in our bodies, either directly or indirectly. They do the majority of the work in cells and are critical for the function, regulation, and structure of tissues and organs.
Recently, we have shown that by administering the NAD+ precursor NMN (Nicotinamide Mononucleotide)in normal drinking water to older mice, NAD+ levels were restored to those normally associated with younger healthy animals. By administering NMN to mice for just one week, our lab demonstrated a robust correction in age-associated metabolic dysfunction and restored muscle mitochondrial function in old mice to levels seen in younger control mice (Gomes et al. 2013).
https://www.lifespan.io/campaigns/can-nmn-increase-longevity…019dfcda6c
Dr. Aubrey De Grey, SENS Foundation, Co-Founder, talks of species that live hundreds of years. We have to understand metabolism and postpone old age.
How can reverse aging by improving repair mechanism. Cells die, and the waste as well as energy byproducts to avoid tissue breakdown with methyl donors.
https://delgadoprotocol.com/product/neuro-insight/#1523582495879-e8979e45-c0bc
Cellular senescence is one phenomenon by which normal cells cease to divide. In their seminal experiments from the early 1960’s, Leonard Hayflick.
Senescent cells increase in many tissues with aging; they also occur in organs associated with many chronic diseases and after radiation or chemotherapy. Senolytics are a class of drugs that selectively eliminate senescent cells.
Cancer cells are immortal, why?
