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Skin and Mouth Biomarkers More Predictive Than Gut

Lifespan.io


 A new study published in mSystems, a journal from the American Society for Microbiology, shows that the skin and mouth microbiomes are better predictors of age than the gut microbiome.

A very broad study

The authors used a very large population that is highly impressive among studies of this kind. Previously, a team containing some of the same researchers had done a gut microbiome study of over four thousand people from multiple countries [1]. This time, the researchers took skin, saliva, and fecal samples from roughly 2,000, 2,500, and 4,500 people, respectively; this study was done with nearly 9,000 people in total, and the team stated that it was the most comprehensive microbiome study done to date. The team used a “random forest” machine learning approach to determine what microbiota were and were not predictive of age [2].

Going mobile: FDA clears world’s first bedside MRI scanner-on-wheels

The FDA has cleared the world’s first portable MRI system, designed to be wheeled to a hospital bedside for scanning a patient’s head and brain.

Developed by Hyperfine Research for people age two and older, the point-of-care imaging system weighs about one-tenth that of a conventional, fixed MRI system. About three feet wide and five feet tall, the device fits in an elevator and runs off an everyday power outlet to create both clinical contrast images and 3D renders.

“More than 40 years after its first use, MRI remains a marvel. Unfortunately, it also remains inaccessible,” Hyperfine Chief Medical Officer Khan Siddiqui said in a statement. “It’s time that MRI made the jump to point of need just like X-ray and ultrasound have before it.”

In vitro self-replication and multicistronic expression of large synthetic genomes

The generation of a chemical system capable of replication and evolution is a key objective of synthetic biology. This could be achieved by in vitro reconstitution of a minimal self-sustaining central dogma consisting of DNA replication, transcription and translation. Here, we present an in vitro translation system, which enables self-encoded replication and expression of large DNA genomes under well-defined, cell-free conditions. In particular, we demonstrate self-replication of a multipartite genome of more than 116 kb encompassing the full set of Escherichia coli translation factors, all three ribosomal RNAs, an energy regeneration system, as well as RNA and DNA polymerases. Parallel to DNA replication, our system enables synthesis of at least 30 encoded translation factors, half of which are expressed in amounts equal to or greater than their respective input levels. Our optimized cell-free expression platform could provide a chassis for the generation of a partially self-replicating in vitro translation system.

Biotech’s Wizard Of Wall Street : Fred Frank At The Forefront of Investment

Wall Street’s Biotech Investment Wizard — On this most recent ideaXme (http://radioideaxme.com/) episode, I was honored to be joined by my friend, and biotech / pharma / healthcare investment banker extraordinaire, Frederick Frank, to talk about his 50-year career history behind the industry’s mega-deals — #Ideaxme #Biopharma #Biotech #WallStreet #Mergers #Acquisitions #VentureCapital #Genentech #Roche #BristolMyersSquibb #PrivateEquity #Health #Wellness #Longevity #Regeneration #LifeExtension #Aging #IraPastor #Bioquark #Regenerage


Ira Pastor, ideaXme exponential health ambassador, interviews Fred Frank, Founder and Chair of Evolution Life Science Partners, an investment bank focused on the needs of life sciences and healthcare companies.

Ira Pastor Comments:

On several recent shows we’ve been discussing some of the novel, alternative funding pools that have been emerging in and around the biotech space, specifically related to some of the unmet medical needs of which we have been focusing on, on the ideaXme show, particularly related to the age-tech and longevity biotech fronts.

We have had guests join us from both the $125 Million Healthy Ageing Challenge program of UKRI (UK Research and Innovation)and the US$30 Million Healthy Longevity Global Grand Challenge of the U.S. National Academy of Medicine. We’ve have also talked to folks at the XPrize Foundation, specifically related to their upcoming inducement prize contest for therapeutics for the diseases of aging.

Biologists Are Already Printing the Deadly COVID-19 Virus

Still, the fact that many labs worldwide are capable of printing viruses is worrisome.

A few years ago, for instance, Canadian researchers alarmed the scientific community when they assembled synthetic horsepox in a lab — a virus closely related to smallpox, which killed hundreds of millions before researchers developed a vaccine.

The same technique, the researchers said at the time, could be be used to bring back smallpox, giving terrorists tools to set off a deadly pandemic.

Scientists find ally in fight against brain tumors: Ebola

Glioblastomas are relentless, hard-to-treat, and often lethal brain tumors. Yale scientists have enlisted a most unlikely ally in efforts to treat this form of cancer — elements of the Ebola virus.

“The irony is that one of the world’s deadliest viruses may be useful in treating one of the deadliest of brain cancers,” said Yale’s Anthony van den Pol, professor of neurosurgery, who describes the Yale efforts Feb. 12 in the Journal of Virology.

The approach takes advantage of a weakness in most cancer tumors and also of an Ebola defense against the immune system response to pathogens.

The pan-genome effector-triggered immunity landscape of a host-pathogen interaction

Plant pathogens elicit an immune response through effector proteins. In turn, plant genomes encode genes that determine species-specific recognition of these effectors by a process known collectively as effector-triggered immunity (ETI). By examining a range of strains of the pathogen Pseudomonas syringae that infect the model plant Arabidopsis thaliana, Laflamme et al. generated a P. syringae Type III Effector Compendium (PsyTEC) and in turn identified the genes responsible for ETI in Arabidopsis. This pan-genome analysis revealed that relatively few A. thaliana genes are responsible for recognizing the majority of P. syringae effectors. These results provide insight into why most pathogenic microbes only infect specific plant species.

Science, this issue p. 763

Effector-triggered immunity (ETI), induced by host immune receptors in response to microbial effectors, protects plants against virulent pathogens. However, a systematic study of ETI prevalence against species-wide pathogen diversity is lacking. We constructed the Pseudomonas syringae Type III Effector Compendium (PsyTEC) to reduce the pan-genome complexity of 5127 unique effector proteins, distributed among 70 families from 494 strains, to 529 representative alleles. We screened PsyTEC on the model plant Arabidopsis thaliana and identified 59 ETI-eliciting alleles (11.2%) from 19 families (27.1%), with orthologs distributed among 96.8% of P. syringae strains. We also identified two previously undescribed host immune receptors, including CAR1, which recognizes the conserved effectors AvrE and HopAA1, and found that 94.7% of strains harbor alleles predicted to be recognized by either CAR1 or ZAR1.

Grateful Dead Drummer’s Quest to End Alzheimer’s

Hart’s demonstrations are entertainment for sure. But his message runs deeper: rhythm and vibration heal the brain. Dementia, he says, is the “loss of rhythm.” And he, along with notables who collaborated on the event — University of California at San Francisco neuroscientist Adam Gazzaley and opera singer Renée Fleming (who lent her soprano to the event’s musical track) — are all at work searching for pathways that can bypass obstacles to function and cognition. Hart has also worked with Dr. Connie Tomaino, who runs the Institute for Music and Neurologic Function, on music as a therapeutic tool for brain function.

Gazzaley is currently conducting clinical trials with healthy older adults to show how a regular regimen of digital rhythm can enhance attention and memory in people with cognitive impairment. Hart has been working with Gazzaley on what will be a downloadable app, their goal to develop a game that challenges one’s rhythmic ability, with the hope of building new neuropathways in the brain. “What we’re talking about here is a deeper and longer immersive experience which can actually harness the brain’s plasticity to change the way it functions,” says Gazzaley.

Taking up an instrument as a child, and playing through adulthood is one proven way to protect one’s brain. But learning later in life is helpful, too. Hart shares the story of his unlikely best friend, Walter Cronkite, who was 73 when he became a Deadhead, and also started playing the drums. In July of 2009, as Cronkite lay dying from complications of cerebrovascular disease, Hart handed him a hand drum. “He could no longer speak, but he could play,” Hart says, tears in his eyes. “He used to ask, ‘When we do we know we have found our groove?’ Well, he found it.”

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