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Scientists crack chemical code of incredibly complex ‘anti-tumor antibiotic’

After 20 years of dedicated research, scientists have cracked the chemical code of an incredibly complex ‘anti-tumor antibiotic’ known to be highly effective against cancer cells as well as drug-resistant bacteria, and have reproduced it synthetically in the lab for the first time.

This major breakthrough and world-first could hail a new era in the design and production of new antibiotics and anticancer agents.

The ‘super substance’ — kedarcidin — was discovered in its natural form by a pharmaceutical company when they extracted it from a soil sample in India almost 30-years-ago. Soil is the natural source of all antibiotics developed since the 1940s but in order for them to be developed as potential drug treatments they must be produced via chemical synthesis.

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Brains of blind people adapt to sharpen sense of hearing, study shows

Now, a pair of research papers published the week of April 22 from the University of Washington — one in the Journal of Neuroscience, the other in the Proceedings of the National Academy of Sciences — use functional MRI to identify two differences in the brains of blind individuals that might be responsible for their abilities to make better use of auditory information.

“There’s this idea that blind people are good at auditory tasks, because they have to make their way in the world without visual information. We wanted to explore how this happens in the brain,” said Ione Fine, a UW professor of psychology and the senior author on both studies.

Instead of simply looking to see which parts of the brain were most active while listening, both studies examined the sensitivity of the brain to subtle differences in auditory frequency.

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Researchers use 3D printer to print glass

For the first time, researchers have successfully 3D printed chalcogenide glass, a unique material used to make optical components that operate at mid-infrared wavelengths. The ability to 3D print this glass could make it possible to manufacture complex glass components and optical fibers for new types of low-cost sensors, telecommunications components and biomedical devices.

In The Optical Society (OSA) journal Optical Materials Express, researchers from the Centre d’Optique, Photonique et Laser (COPL) at Université Laval in Canada, Patrick Larochelle and his colleagues, describe how they modified a commercially available 3D printer for glass extrusion. The new method is based on the commonly used technique of fused deposition modeling, in which a plastic filament is melted and then extruded layer-by-layer to create detailed 3D objects.

“3D printing of optical materials will pave the way for a new era of designing and combining materials to produce the photonic components and fibers of the future,” said Yannick Ledemi, a member of the research team. “This new method could potentially result in a breakthrough for efficient manufacturing of infrared optical components at a low cost.”

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The Kaufmann Protocol: Why we age and how to stop it

Join us at 7pm tonight! watch the livestream from our YouTube channel at 7pm.


Dr. Sandra Kaufmann

The Author of the book, The Kaufmann Protocol: Why we age and how to stop it.

The Kaufmann Protocol is the first comprehensive approach to aging that tackles why we age and then recommends a strategic, scientific formulation to decelerate the process.

The book brings practical information to everyday people and takes the science of aging out of the laboratory and into the real world.

Surgeons Just Sent a Tiny, Autonomous Bot Into a Heart Valve

In a world first, surgeons just used a self-navigating surgery robot in an experimental surgery — training a robotic catheter to find its way to a leaky valve in a pig’s heart.

The new robot, described in research published in the journal Science Robotics on Wednesday, marks the beginning of the transition from robotic surgical tools to true robot-assisted surgeries, where autonomous devices can actually take the load off of overburdened human doctors.

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A breakthrough in the study of laser/plasma interactions

A new 3D particle-in-cell (PIC) simulation tool developed by researchers from Lawrence Berkeley National Laboratory and CEA Saclay is enabling cutting-edge simulations of laser/plasma coupling mechanisms that were previously out of reach of standard PIC codes used in plasma research. More detailed understanding of these mechanisms is critical to the development of ultra-compact particle accelerators and light sources that could solve long-standing challenges in medicine, industry, and fundamental science more efficiently and cost effectively.

In laser-plasma experiments such as those at the Berkeley Lab Laser Accelerator (BELLA) Center and at CEA Saclay—an international research facility in France that is part of the French Atomic Energy Commission—very large electric fields within plasmas that accelerate particle beams to over much shorter distances when compared to existing accelerator technologies. The long-term goal of these laser-plasma accelerators (LPAs) is to one day build colliders for high-energy research, but many spin offs are being developed already. For instance, LPAs can quickly deposit large amounts of energy into solid materials, creating dense plasmas and subjecting this matter to extreme temperatures and pressure. They also hold the potential for driving free-electron lasers that generate light pulses lasting just attoseconds. Such extremely short pulses could enable researchers to observe the interactions of molecules, atoms, and even subatomic particles on extremely short timescales.

Supercomputer simulations have become increasingly critical to this research, and Berkeley Lab’s National Energy Research Scientific Computing Center (NERSC) has become an important resource in this effort. By giving researchers access to physical observables such as particle orbits and radiated fields that are hard to get in experiments at extremely small time and length scales, PIC simulations have played a major role in understanding, modeling, and guiding high-intensity physics experiments. But a lack of PIC codes that have enough computational accuracy to model laser-matter interaction at ultra-high intensities has hindered the development of novel particle and light sources produced by this interaction.

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