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Category: biotech/medical – Page 2,465

Epigenetic Reprogramming in Mammalian Development

Circa 2001

DNA methylation is a major epigenetic modification of the genome that regulates crucial aspects of its function. Genomic methylation patterns in somatic differentiated cells are generally stable and heritable. However, in mammals there are at least two developmental periods—in germ cells and in preimplantation embryos—in which methylation patterns are reprogrammed genome wide, generating cells with a broad developmental potential. Epigenetic reprogramming in germ cells is critical for imprinting; reprogramming in early embryos also affects imprinting. Reprogramming is likely to have a crucial role in establishing nuclear totipotency in normal development and in cloned animals, and in the erasure of acquired epigenetic information. A role of reprogramming in stem cell differentiation is also envisaged.

DNA methylation is one of the best-studied epigenetic modifications of DNA in all unicellular and multicellular organisms. In mammals and other vertebrates, methylation occurs predominantly at the symmetrical dinucleotide CpG (1–4). Symmetrical methylation and the discovery of a DNA methyltransferase that prefers a hemimethylated substrate, Dnmt1 , suggested a mechanism by which specific patterns of methylation in the genome could be maintained. Patterns imposed on the genome at defined developmental time points in precursor cells could be maintained by Dnmt1, and would lead to predetermined programs of gene expression during development in descendants of the precursor cells (5, 6). This provided a means to explain how patterns of differentiation could be maintained by populations of cells. In addition, specific demethylation events in differentiated tissues could then lead to further changes in gene expression as needed.

Neat and convincing as this model is, it is still largely unsubstantiated. While effects of methylation on expression of specific genes, particularly imprinted ones and some retrotransposons , have been demonstrated in vivo, it is still unclear whether or not methylation is involved in the control of gene expression during normal development (9–13). Although enzymes have been identified that can methylate DNA de novo (Dnmt3a and Dnmt3b) (14), it is unknown how specific patterns of methylation are established in the genome. Mechanisms for active demethylation have been suggested, but no enzymes have been identified that carry out this function in vivo (15–17). Genomewide alterations in methylation—brought about, for example, by knockouts of the methylase genes—result in embryo lethality or developmental defects, but the basis for abnormal development still remains to be discovered (7, 14).

Nutrition for Longevity

An all-star panel of experts in nutritional studies with an emphasis on longevity. At some point in your life, you have heard the following. “Eat the right food. It will help you live longer.” What if I told you the right food could help you heal as well. This panel of longevity driven nutritionist will give you a broad range of fact-based regiments and compelling individual opinions on Nutrition and longevity.
This segment will cover many diverse understandable methods that can make a change in longevity for you or your loved ones. Fill yourself with the knowledge of proper nutrition for longevity.

Speakers Will Include:
Brian Clement – Plant-Based & founder of “Hippocrates Health Institute”
A typical American growing up in the New Jersey/New York area, Brian likes to joke that he was a pioneer in the field of obesity—he was fat even before many Americans were fat! Raised in an Irish household on the standard American diet of meat, processed foods, and sugary sodas, he was unfit and gasping for air every few steps. When he was 20 years old, he was dating a girl whose best friend’s boyfriend was 30—and a vegetarian. Despite the fact he had been more or less educated by his family that the body would die without animal-based foods, the lure of an influential peer inspired him to give up meat in one fell swoop. For the first year and a half, he kept his vegetarian diet a secret from his family. Yet after losing 120 pounds and experiencing the difference in his health, he came out of the proverbial closet (much to his family’s dismay!) and became a complete vegan three years later.

Scott Joseph – Fruitarian & author of “Perfect Human Food”
Perfect [Human] Food — Written by Scott Joseph © 2019 Approx 95% of all illnesses and diseases are “DIET-RELATED” so you could cure and prevent virtually all health issues… if you simply eat the right FOOD. For example, animals in nature, away from all human interference, do not develop “diet-related” illnesses and diseases such as; Heart Attacks, Cancers, Strokes, Diabetes, Alzheimer’s, Depression, Anxiety, ADD, Arthritis, Osteoporosis, Acne, Psoriasis, Cavities, Tooth Decay, Colds, Flu, Headaches, Glaucoma, Cataracts, Obesity and hundreds of other health issues that humans develop… because they instinctively eat the foods that were specifically designed for their species.
Knowing that all other living creatures living in the wild, eat a specific diet and have virtually perfect health, except our pets, it only makes sense that the super healthy natural diet of our closest living relatives is the answer to curing and preventing virtually all of our health issues.

Wendi Blum – Founder of “Founder of Create Your Best Life”
Wendi Blum worked in the pharmaceutical industry for over 20 years until (at age 45) felt a calling to completely change every aspect of her life. After two decades in a successful sales career (having worked for Zenecca Pharmaceuticals, PDI and Bristol Myers Squibb, wearing many different hats including advocacy, sales, and training) Wendi decided to re-write the story of her life literally and become an international inspirational speaker, author, workshop leader, success coach, and life-shift retreat guru.
She is the author of 5 books – known for her focus on reinvention, goal mastery, and business savvy – she is known as “the queen of reinvention” Her titles include: “Your Life, Your Destiny, Uncover Yours, LifeShift” and “Goals Setting Workbook: Success Strategies for The New Economy” – and many more. Blum is known for her blend of Spiritual flare with business savvy” because of how she merges these two powerful components together.

Bill Faloon — Director and Co-founder of the “Life Extension Foundation”.

Bill Faloon compiled the 1,500-page medical reference book Disease Prevention and Treatment, and his latest book is Pharmocracy: How Corrupt Deals and Misguided Medical Regulations Are Bankrupting America—and What to Do About It. He is also director and co-founder of the Life Extension Foundation, a consumer advocacy organization that funds research and disseminates information to consumers about optimal health. Mr. Faloon has made hundreds of media appearances, including guest spots on The Phil Donohue Show, Tony Brown’s Journal, and ABC News Day One, and has been interviewed Newsweek and other magazines.

Continue reading “Nutrition for Longevity” | >

Pig-Pen effect: Mixing skin oil and ozone can produce a personal pollution cloud

When ozone and skin oils meet, the resulting reaction may help remove ozone from an indoor environment, but it can also produce a personal cloud of pollutants that affects indoor air quality, according to a team of researchers.

In a computer model of indoor environments, the researchers show that a range of volatile and semi-volatile gases and substances are produced when , a form of oxygen that can be toxic, reacts with skin oils carried by soiled clothes, a reaction that some researchers have likened to the less-than-tidy Peanuts comic strip character.

“When the ozone is depleted through , we become the generator of the primary products, which can cause sensory irritations,” said Donghyun Rim, assistant professor of architectural engineering and an Institute for CyberScience associate, Penn State. “Some people call this higher concentration of pollutants around the human body the personal cloud, or we call it the ”Pig-Pen Effect.””.

Microscopic glass blowing used to make tiny optical lenses

Inserting air into hot glass to form a bubble has been used to make glass objects since Roman times. In new work, researchers apply these same glass blowing principles on a microscopic scale to make specialized miniature cone-shaped lenses known as axicons.

Axicons are used to shape in a way that is beneficial for optical drilling, imaging and creating for manipulating particles or cells. These lenses have been known for more than 60 years, but their fabrication, especially when small, is not easy.

“Our technique has the potential of producing robust miniature axicons in glass at a low cost, which could be used in miniaturized imaging systems for biomedical imaging applications, such as , or OCT,” said research team member Nicolas Passilly from FEMTO-ST Institute in France.

Ebola hot spots shift as pattern of spread fluctuates

In the past 10 days, officials have recorded nearly 100 new cases of Ebola in the ongoing outbreak in the Democratic Republic of the Congo (DRC), a sign of fluctuating transmission throughout North Kivu and Ituri provinces, the World Health Organization (WHO) said in an update.

Today, the DRC will likely confirm another 18 new cases, which will raise the outbreak total to 2,265. As of yesterday, there were 1,510 deaths, and 269 suspected cases are still being investigated.

Researchers grow active mini-brain-networks

Cerebral organoids are artificially grown, 3D tissue cultures that resemble the human brain. Now, researchers from Japan report functional neural networks derived from these organoids in a study publishing June 27 in the journal Stem Cell Reports. Although the organoids aren’t actually “thinking,” the researchers’ new tool—which detects neural activity using organoids—could provide a method for understanding human brain function.

“Because they can mimic cerebral development, can be used as a substitute for the to study complex developmental and neurological disorders,” says corresponding author Jun Takahashi, a professor at Kyoto University.

However, these studies are challenging, because current cerebral organoids lack desirable supporting structures, such as blood vessels and surrounding tissues, Takahashi says. Since researchers have a limited ability to assess the organoids’ neural activities, it has also been difficult to comprehensively evaluate the function of neuronal networks.

A vaccine for Alzheimer’s is on the verge of becoming a reality

There are certain enzymes — proteins — plaques that help cause Alzheimer’s, just recently in fact {which I as most could have told them} the gut microbes and mouth microbes are found to assist in Dementia and Alzheimers. But I and Hippocrates as others have been declaring that fact for quite some time… Respect AEWR wherein the amazing gathered data of mankind has yielded the many causes and a cure for aging…

For decades, research into Alzheimer’s has made slow progress, but now a mother and daughter team think they have finally found a solution – a vaccine that could inoculate potential sufferers.

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