Lifeboat Foundation

Growing organs in the lab is an enduring sci-fi trope, but as stem cell technology brings it ever closer to reality, scientists are beginning to contemplate the ethics governing disembodied human tissue.

So-called organoids have now been created from gut, kidney, pancreas, liver and even brain tissue. Growing these mini-organs has been made possible by advances in stem cell technology and the development of 3D support matrices that allow cells to develop just like they would in vivo.

Unlike simple tissue cultures, they exhibit important structural and functional properties of organs, and many believe they could dramatically accelerate research into human development and disease.

Continue reading “The Ethics of Organoids: Scientists Weigh in on New Mini-Organs” »

This biomedical advance has long been a dream and a quandary for scientists hoping to address a critical shortage of donor organs.

Every ten minutes, a person is added to the national waiting list for organ transplants. And every day, 22 people on that list die without the organ they need. What if, rather than relying on a generous donor, you could grow a custom organ inside an animal instead?

In Brief:

• A drug seems to be showing signs of reversing the effects of aging in dogs and mice. Studies are being conducted on the effectiveness in humans.
• The drug has some major side effects linked to it and there is no guarantee it will be as effective in humans.

Aging is a spectre we all must face one day…but is this the way that it will always be? Medical researchers hope to delay or even reverse the onset of aging, and some are already claiming that they’ve made inroads to immortality.

Researchers at EPFL’s Laboratory of Photonic Materials and Fibre Devices, which is run by Fabien Sorin, have come up with a simple and innovative technique for drawing or imprinting complex, nanometric patterns on hollow polymer fibers. Their work has been published in Advanced Functional Materials.

The potential applications of this breakthrough are numerous. The imprinted designs could be used to impart certain optical effects on a fiber or make it water-resistant. They could also guide stem–cell growth in textured fiber channels or be used to break down the fiber at a specific location and point in time in order to release drugs as part of a smart bandage.

Intelligence Advanced Research Projects Activity (IARPA), the intelligence community’s research arm, will soon launch two programs designed to detect fake fingerprints and develop devices to collect fingerprint data without the aid of a human operator, according to a report by GCN.

The Odin program, which is scheduled to begin with four prime developers in early March, will develop detection technologies that can spot presentation attacks on biometric devices that attempt to spoof physical biometric samples, said Chris Boehnen, senior program manager at IARPA.

Boehnen said that prosthetic fingers, fake fingerprints made with wood glue and other tactics can dupe current fingerprint sensors.

Continue reading “IARPA launching two programs aimed at making fingerprints more reliable biometrics” »

Is Synbio the next big thing? Hmmm; depends. If we’re talking about ensuring that we have a solid foundation/ infrastructure (including platforms; etc.) on QC 1st then with the existing evolution and maturity of the fundamentals around Synbio as a 1st step; then accelerating the further maturity of Synbio into creating super humans and singularity? My answer is yes. If we’re not even considering that we need QC and just focused on Synbio only; my answer is No as QC will be required as a foundation for things like real Humanoid AI, cell circuited humans/ super humans, etc.

Why we might soon be buying silk, wood, and more fabricated out of genetic code.

A Salmonella pathogen manages a trade-off between virulence and transmission by manipulating the gut–brain axis and blocking appetite loss.

Could we eventually see a day where we have cell circuitry nanobot pill that eliminates hunger and obesity as replacement to gastric bypasses? Maybe.

The human body responds to starving conditions, such as famine, to promote the chance of survival. It reduces energy expenditure by stopping heat production and promotes feeding behavior. These “hunger responses” are activated by the feeling of hunger in the stomach and are controlled by neuropeptide Y (NPY) signals released by neurons in the hypothalamus. However, how NPY signaling in the hypothalamus elicits the hunger responses has remained unknown.

Sympathetic motor neurons in the medulla oblongata are responsible for heat production by brown adipose tissue (BAT). Researchers centered at Nagoya University have now tested whether the heat-producing neurons respond to the same hypothalamic NPY signals that control hunger responses. They injected NPY into the hypothalamus of rats and tested the effect on heat production. Under normal conditions, blocking inhibitory GABAergic receptors or stimulating excitatory glutamatergic receptors in the sympathetic motor neurons induced heat production in BAT. After NPY injection, stimulating glutamatergic receptors did not produce heat, but inhibiting GABAergic receptors did. The study was recently reported in Cell Metabolism.

Continue reading “Researchers uncover how brain circuit elicits hunger responses during starvation” »

https://youtube.com/watch?v=6A1knkZiysQ

Clearing out senescent cells could lead to better fitness and health as we age.

From around age forty we start to lose muscle mass due to various aging processes, one of these processes is the accumulation of senescent cells. Senescent cells are simply cells that have become damaged or have reached their maximum number of divisions. Normally these cells are shut down by a kind of self destruct program inside the cell, ready to be disposed of by the immune system.

Continue reading “Senolytics – Taking Out The Trash Might Keep You Fit And Healthy” »