Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 2,406

The compounds — AP39, AP123 and RT01 — have been designed to selectively deliver minute quantities of the gas hydrogen sulphide to the mitochondria in cells and help the old or damaged cells to generate the ‘energy’ needed for survival and to reduce senescence.

In the samples used, the number of senescent cells — older cells that have deteriorated and stopped dividing — was reduced by up to 50 per cent.

The team also identified two splicing factors — a component of cells — that play a key role in when and how endothelial cells become senescent.

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A team of researchers from several institutions in Iceland and the U.S. has conducted a unique blood serum investigation and discovered multiple protein networks that are involved in the aging process. In their paper published in the journal Science, the group describes their study and what they found.

Prior research has shown that when older mice have their blood systems connected to younger mice, the older mice experience improvements in age-related organ deterioration. This finding has led scientists to suspect that aging might be caused by something in the blood. In this new effort, the researchers sought to test this idea by studying proteins in the circulatory system.

The study consisted of analyzing blood samples from 5,457 people living in Iceland, all of whom were over the age of 65 and who were participants in an ongoing study called Age, Gene/Environment Susceptibility. The volunteers had also been chosen specifically to represent a cross section of the people living in Iceland. The major part of the analysis involved creating a panel of DNA aptamers (short sequences that bind to proteins) that could be used to recognize proteins, both known and unknown. Blood serum from the volunteers was then compared against the panels and the results were analyzed by a computer looking for patterns.

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Roboticists are envisioning a future in which soft, animal-inspired robots can be safely deployed in difficult-to-access environments, such as inside the human body or in spaces that are too dangerous for humans to work, in which rigid robots cannot currently be used. Centimeter-sized soft robots have been created, but thus far it has not been possible to fabricate multifunctional flexible robots that can move and operate at smaller size scales.

A team of researchers at Harvard’s Wyss Institute for Biologically Inspired Engineering, Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), and Boston University now has overcome this challenge by developing an integrated fabrication process that enables the design of on the millimeter scale with micrometer-scale features. To demonstrate the capabilities of their new technology, they created a robotic soft spider – inspired by the millimeter-sized colorful Australian peacock spider – from a single elastic material with body-shaping, motion, and color features. The study is published in Advanced Materials.

“The smallest soft robotic systems still tend to be very simple, with usually only one degree of freedom, which means that they can only actuate one particular change in shape or type of movement,” said Sheila Russo, Ph.D., co-author of the study. Russo helped initiate the project as a Postdoctoral Fellow in Robert Wood’s group at the Wyss Institute and SEAS and now is Assistant Professor at Boston University. “By developing a new hybrid technology that merges three different fabrication techniques, we created a soft robotic spider made only of silicone rubber with 18 degrees of freedom, encompassing changes in structure, motion, and color, and with tiny features in the micrometer range.”

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There is a 3-day conference in Brussels on November 8–10 for those of you in Europe interested in aging research.

The Eurosymposium on Healthy Ageing (EHA) is an international event that provides a unique opportunity for researchers, government officials, biotech executives, entrepreneurs, and non-governmental institutions from around the world to meet, network, and forge new scientific collaborations.

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Cancer isn’t some foreign illness invading your body – it’s essentially just regular cells dividing out of control. Current cancer treatments like chemotherapy and radiotherapy are designed to kill tumors, but they often take down healthy cells as well. An emerging technique could provide a more targeted approach, stopping tumorous cells from proliferating and effectively putting the cancer to sleep.

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If you thought you were safe from Lyme disease because you don’t live in New England, where the tick-borne illness first appeared, think again. Now, all 50 states plus the District of Columbia have residents who have tested positive for Lyme, a bacterial infection that can cause a wide variety of symptoms, including joint aches, fatigue, facial palsy and neck stiffness.

This news comes from a report from the clinical laboratory Quest Diagnostics, which analyzed the results of 6 million blood tests doctors had ordered to diagnose Lyme disease in their patients. The report found that Pennsylvania had the most positive cases last year: 10,001.

The Pennsylvania tally, along with that of the six New England states — Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island and Vermont — accounted for about 60 percent of the country’s Lyme disease cases. Positive results grew by 50 percent in New England and by 78 percent in Pennsylvania from 2016 to 2017.

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Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have developed a drug-delivery system that allows rapid response to heart attacks without surgical intervention. In laboratory and animal testing, the system proved to be effective at dissolving clots, limiting long-term scarring to heart tissue and preserving more of the heart’s normal function.

“Our approach would allow health-care providers to begin treating heart attacks before a patient reaches a surgical suite, hopefully improving patient outcomes,” says Ashley Brown, corresponding author of a paper on the work and an assistant professor in the Joint Biomedical Engineering Program (BME) at NC State and UNC. “And because we are able to target the blockage, we are able to use powerful drugs that may pose threats to other parts of the body; the targeting reduces the risk of unintended harms.”

Heart attacks, or myocardial infarctions, occur when a thrombus – or clot – blocks a blood vessel in the heart. In order to treat heart attacks, doctors often perform surgery to introduce a catheter to the blood vessel, allowing them to physically break up or remove the thrombus. But not all patients have quick access to surgical care.

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