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In genetics and developmental biology, somatic cell nuclear transfer (SCNT) is a laboratory technique for creating an ovum with a donor nucleus. It can be used in embryonic stem cell research, or in regenerative medicine where it is sometimes referred to as “therapeutic cloning”.

https://www.biointeractive.org/classroom-resources/somatic-c…94yzh8K2uw

LOS ANGELES (AP) — New research gives some biological clues to why women may be more likely than men to develop Alzheimer’s disease and how this most common form of dementia varies by sex.

At the Alzheimer’s Association International Conference in Los Angeles on Tuesday, scientists offered evidence that the disease may spread differently in the brains of women than in men. Other researchers showed that several newly identified genes seem related to the disease risk by sex.

Two-thirds of Alzheimer’s cases in the U.S. are in women and “it’s not just because we live longer,” said Maria Carrillo, the association’s chief science officer. There’s also “a biological underpinning” for sex differences in the disease, she said.

Gut microbes produce compounds that prime immune cells to destroy harmful viruses in the brain and nervous system, according to a mouse study published today in eLife.

The findings suggest that having healthy and diverse microbiota is essential for quickly clearing viruses in the nervous system to prevent paralysis and other risks associated with diseases such as multiple sclerosis.

A condition that causes progressive damage to nerve cells, multiple sclerosis has become more common over the past several decades. Viral infections in the brain or spinal cord are thought to trigger this disease. Some scientists believe that changes in the way we eat, increased sanitation or growing antibiotic use may be causing detrimental changes in the that live within the human body, potentially increasing the risk of multiple sclerosis and other related diseases.

Researchers at the University of Helsinki have shown why the regenerative capacity of the cells lining the intestines declines with age and that targeting a particular enzyme can restore the regenerative potential of this tissue.

Notum blocks the Wnt pathway

During normal function, the cells of the intestinal epithelium, a single cell layer that forms the lining of both the small and large intestine, are replaced by stem cells, which create healthy replacement cells to counter losses from injury, damage, disease, and aging. These cells are roused into action via the Wnt signaling pathway, which is activated through signals sent by other cells in the tissue.

But a less-noticed win for DeepMind, the artificial-intelligence arm of Google’s parent Alphabet Inc., at a biennial biology conference could upend how drugmakers find and develop new medicines. It could also dial up pressure on the world’s largest pharmaceutical companies to prepare for a technological arms race. Already, a new breed of upstarts are jumping into the fray.


Alphabet’s DeepMind cracked a problem that long vexed biologists, heating up a technological arms race in health care.