Government representatives from nearly 170 countries will this month consider whether to temporarily ban the release of organisms carrying gene drives — a controversial technology that can quickly propagate a chosen gene throughout a population. The technique has the potential to eradicate disease, control pests and alter entire ecosystems, but with unpredictable consequences — leading some groups to call for a global moratorium on its field applications.
Research is moving fast on the divisive genetic technology, which could help to eradicate diseases but also risks altering ecosystems in unpredictable ways.
Michael B. Fossel, M.D., Ph.D. (born 1950, Greenwich, Connecticut) was a professor of clinical medicine at Michigan State University and is the author of several books on aging, who is best known for his views on telomerase therapy as a possible treatment for cellular senescence. Fossel has appeared on many major news programs to discuss aging and has appeared regularly on National Public Radio (NPR). He is also a respected lecturer, author, and the founder and former editor-in-chief of the Journal of Anti-Aging Medicine (now known as Rejuvenation Research).
Prior to earning his M.D. at Stanford Medical School, Fossel earned a joint B.A. (cum laude) and M.A. in psychology at Wesleyan University and a Ph.D. in neurobiology at Stanford University. He is also a graduate of Phillips Exeter Academy. Prior to graduating from medical school in 1981, he was awarded a National Science Foundation fellowship and taught at Stanford University.
In addition to his position at Michigan State University, Fossel has lectured at the National Institute for Health, the Smithsonian Institution, and at various other universities and institutes in various parts of the world. Fossel served on the board of directors for the American Aging Association and was their executive director.
Fossel has written numerous articles on aging and ethics for the Journal of the American Medical Association and In Vivo, and his first book, entitled Reversing Human Aging was published in 1996. The book garnered favorable reviews from mainstream newspapers as well as Scientific American and was published in six languages. A magisterial academic textbook on by Fossel entitled Cells, Aging, and Human Disease was published in 2004 by Oxford University Press.
Since his days as a teacher at Stanford University, Fossel has studied aging from a medical and scientific perspective with a particular emphasis on premature aging syndromes such as progeria, and since at least 1996 he has been a strong and vocal advocate of [telomerase therapy]] as a potential treatment of age-related diseases, disorders, and syndromes such as progeria, Alzheimer’s disease, atherosclerosis, osteoporosis, cancer, and other conditions. However, he is careful to qualify his advocacy of telomerase therapy as being a potential treatment for these conditions rather than a “cure for old age” and a panacea for age-related medical conditions, albeit a potential treatment that could radically extend the maximum human life span and reverse the aging process in most people. Specifically, Fossel sees the potential of telomerase therapy as being the single most effective point of intervention in a wide variety of age-related medical conditions. His new book, The Telomerase Revolution, (BenBella, 2015) gives a careful explanation of aging, age-related diseases, and the prospects for intervention, including upcoming human trials.
ASHEVILLE, North Carolina — A chickenpox outbreak at a private school now ranks as North Carolina’s largest since a vaccine for the virus became available more than 20 years ago, health officials say.
The viral infection manifests in an itchy rash in most cases and is not typically life-threatening. But the outbreak at Asheville Waldorf should cause concern, said Dr. Jennifer Mullendore of Buncombe County Department of Health and Human Services.
A tiny transparent worm could be the key to finding out how to stop the frailty and ill health which often comes with old age.
British scientists are sending tens of thousands of worms into space in a government backed project to see if two drugs can prevent or slow down muscle wasting brought on by microgravity.
In space, the 1mm long c-elegans worms have nothing to push against to maintain their muscle mass and so quickly start losing strength, mirroring the effect experienced by elderly people back on Earth or those with conditions like muscular dystrophy.
Taking one or more pills every day can be a hassle, with many people either forgetting or just not bothering. There could soon be an alternative, however. An experimental system that packs a week’s worth of timed-release doses into one capsule has shown promising results in its first clinical study.
More information on the search for natural senolytics (that clear the senescent cells and potentially make us younger)- on ficetin, found in abundance for example in strawberries, a newly published study and discussion in the blog of Josh Mitteldorf. But we still would have to consume around 20 kg strawberries for two consecutive days to reach the dose used in the happy longer living mice!
Senolytic drugs have been the most promising near-term anti-aging therapy since the ground-breaking paper by van Deursen of Mayo Clinic published in 2011. The body accumulates senescent cells as we age, damaged cells that send out signal molecules that in turn modify our biochemistry in a toxic, pro-inflammatory direction. Though the number of such cells is small, the damage they do is great. Van Deursen showed that just getting rid of these cells could increase lifespan of mice by ~25%. But he did it with a trick, using genetically engineered mice in which the senescent cells had a built-in self-destruct switch.
After that, the race was on to find chemical agents that would do the same thing without the genetically engineered self-destruct. They must selectively kill senescent cells, while leaving all other cells unharmed. It’s a tall order, because even a little residual toxicity to normal cells can be quite damaging. Before last week, the two best candidates wereFOXO4-DRIand a combination ofquercetin with dasatinib.
I’ve written in the past ( here and here ) that senolytic drugs are our best prospect for a near-term lift on the road to anti-aging medicine.
For now, the best advice that doctors have is to wash your hands to avoid transmitting infections — a small precaution to avoid the long-term after-effects of AFM.
“We have had a couple people who’ve had some pretty good recovery,” Marcus says. “Most people have had a little bit of recovery, but unfortunately, we haven’t seen anybody who’s had a full recovery from this. It’s really discouraging.”
The Peptides and Proteins lab at the Institute for Research in Biomedicine (IRB Barcelona) modified the amino acid chain chlorotoxin—present in scorpion venom—to carry medicine across humans’ blood-brain barrier (BBB).
An important mechanism for protecting the brain from harmful substances, the roadblock also prevents medication used to treat neurological diseases and tumors from entering the organ.
