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A Cure for Cancer? How CAR T-Cell Therapy is Revolutionizing Oncology

CAR-T therapy has been hailed as a cure for cancer, but what really is this ‘miraculous technology’ and what can we actually expect from it?

The field of immuno-oncology is booming with billions of euros in investment. The ability to rewire our own immune system to fight cancer has certainly created huge expectations. After the success of the first checkpoint inhibitor drugs on the market, many are turning their attention to CAR-T cell therapy.

There are two CAR-T therapies already on the market. The field is now booming, with over 800 CAR-T clinical trials running. But is this therapy really a cure for cancer, as many seem to believe? Can the technology meet such high expectations? Are side effects a concern? Is it worth the huge price tag? To answer the most burning questions, I talked with some of the leaders in this field to draw an overview of the current state of CAR-T technology.

Three aspirins a week helps you live longer by a fifth, research says

Older people could significantly increase their chances of enjoying a long retirement by taking aspirin regularly, according to new research.

Pensioners who took the drug at least three times a week were almost a fifth more likely to be alive about a decade later than those who did not.

The findings of the study bolster a growing body of evidence about the benefits of aspirin.

Researchers Create Ultimate Non-Stick Coating That Repels Everything – Even Viruses and Bacteria

A self-cleaning surface that repels even the deadliest superbugs: Researchers create the ultimate non-stick coating, with medical settings and food industry in mind.

A team of researchers at McMaster University has developed a self-cleaning surface that can repel all forms of bacteria, preventing the transfer of antibiotic-resistant superbugs and other dangerous bacteria in settings ranging from hospitals to kitchens.

The new plastic surface — a treated form of conventional transparent wrap — can be shrink-wrapped onto door handles, railings, IV stands and other surfaces that can be magnets for bacteria such as MRSA and C. difficile.

Certain Foods Can Cure Infections (In The Lab, That Is…)

A recent Forbes article discussed how minestrone soup could stave off growth of a particular type of malaria. No, this did not mean that we should forget about being excited about a potential new malaria vaccine or no longer take malaria pills when traveling to malaria-ridden regions. Nor did it mean that treating malaria would now become a gourmet endeavor for discerning palates. But the concept was interesting: a science teacher engaged students in an experiment, and found that compared to other soups (yes, soups), minestrone in particular had the strongest ability to prevent growth of the organism causing malaria. In a test tube, that is.

Other foods have also been found to reduce bacteria and stave off illness, but again, this has been in the laboratory, not necessarily in the gut, respiratory tract, urinary tract, or skin. Let’s take garlic. Some like it, some don’t. But using garlic in its pure form or as an extract has become increasingly popular, especially for those exploring alternative medicine options. Its potential uses have ranged far and wide, including treatment of chronic illnesses such as diabetes mellitus and heart disease, as well as infections ranging from bacteria, fungi, and cold viruses. The active antimicrobial component of garlic is allicin, which acts to inhibit enzyme activity necessary for bacterial growth and replication. While studies on garlic’s benefits have been extensive, and many both in and out of the laboratory have been positive, there continues to be need for longer term trials and placebo-controlled studies to assess its actions. The larger studies, to date, have been in the lab. Or perhaps in the kitchen. A study looking at the antibacterial effects of garlic on hamburger meat, specifically limiting growth of the bacteria staphylococcus aureus, demonstrated that adequate amounts of garlic extract added to hamburger meat kept these nasty bugs out for up to two months when refrigerated. If you like garlic-flavored hamburgers, then this is certainly a good way to go. Tasty, and staphylococcus-free!

Curcumin, the active ingredient in turmeric, has also had its day in the limelight when it comes to various medicinal properties. Besides its potential benefit in reducing growth of cancerous tumors, it has also been investigated regarding properties including anti-viral, anti-bacterial, and anti-fungal effects. Many of the results regarding curcumin’s effects have remained in the laboratory, with clinical trials still pending. The most promising work in curcumin’s anti-bacterial effect has been in combating growth of helicobacter pylori, a bacterial pathogen which contributes to gastritis and gastric ulcers. But even in this setting, curcumin was found to be beneficial only when combined with existing medications to treat this disease.

Ending Age-Related Diseases: 2020

We will be returning in 2020 to host our third conference in New York City and brings together the leading experts in aging research and biotech business and investment. Building on the success of our 2018 and 2019 conferences we will continue to bring you the latest research, business, and investment talks from some of the top leaders in their fields.

We will be releasing more information about the conference in the coming months as we confirm speakers, venue, and dates. If you would like to stay informed about developments and ticket offers you may wish to sign up for the conference mailing list below.

Study shows how mitochondria can shield cancer cells from chemotherapy

Chemotherapy is a powerful weapon in the fight against cancer, but the complex nature of the disease means that it doesn’t always produce the desired result. Scientists at the Salk Institute have been researching some of the cellular processes behind these evasive abilities, uncovering a new mechanism that could pave the way for new treatments that see chemotherapy maintain the upper hand.

The work was carried out at the Salk Institute’s Molecular and Cell Biology Laboratory, where medical scientists led by Gerry Shadel set out to investigate the role mitochondria might play in the effectiveness of chemotherapy.

Mitochondria is best known as the power generator of the vast majority of cells, but the scientists have found that it can also act as an early warning sign when something’s not quite right. While most of the DNA we carry is packed inside the nucleus of the cell, mitochondria packs its own small set of DNA, called mtDNA.

New CRISPR-based system targets amplified antibiotic-resistant genes

Taking advantage of powerful advances in CRISPR gene editing, scientists at the University of California San Diego have set their sights on one of society’s most formidable threats to human health.

A research team led by Andrés Valderrama at UC San Diego School of Medicine and Surashree Kulkarni of the Division of Biological Sciences has developed a new CRISPR-based gene-drive system that dramatically increases the efficiency of inactivating a gene rendering bacteria antibiotic-resistant. The new system leverages technology developed by UC San Diego biologists in insects and mammals that biases genetic inheritance of preferred traits called “active genetics.” The new “pro-active” genetic system, or Pro-AG, is detailed in a paper published December 16 in Nature Communications.

Widespread prescriptions of and use in animal food production have led to a rising prevalence of antimicrobial resistance in the environment. Evidence indicates that these environmental sources of antibiotic resistance are transmitted to humans and contribute to the current health crisis associated with the dramatic rise in drug-resistant microbes. Health experts predict that threats from antibiotic resistance could drastically increase in the coming decades, leading to some 10 million drug-resistant disease deaths per year by 2050 if left unchecked.

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