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Category: biotech/medical – Page 2265
Facebook is aggressively being used by anti-vaccination advocates to target pregnant women with sponsored advertisements to spread false information and conspiracy theories as the US battles a climbing measles outbreak.
A sponsored ad found by Quartz journalist Jeremy Merrill shows the anti-vaccination organisation Stop Mandatory Vaccination targeting women ages 20 to 60 who have expressed interest in pregnancy living in the state of Washington – where the governor recently declared a state of emergency over the measles outbreak.
Nearly 50 children and young adults in Clark County, Washington have become sickened by the disease since January.
These molecules not only rapidly improve symptoms, but remarkably, also appear to renew the underlying brain impairments causing memory loss in preclinical models.
“Currently there are no medications to treat cognitive symptoms such as memory loss that occur in depression, other mental illnesses and aging,” says Dr. Etienne Sibille, Deputy Director of the Campbell Family Mental Health Research Institute at CAMH and lead scientist on the study.
What’s unique and promising about these findings, in the face of many failures in drug development for mental illness, is that the compounds are highly targeted to activate the impaired brain receptors that are causing memory loss, he says.
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A research team led by Professor Johann de Bono at the Institute of Cancer Research, London has successfully tested a new drug that has infiltrated different forms of cancer in an ongoing human trial [1].
The drug is called tisotumab vedotin (TV) and works like a ‘Trojan Horse’ by hiding a cancer-killing payload inside an antibody, which allows it to infiltrate the tumor and attack it from the inside.
The antibody seeks out a surface receptor on tumor cells known as ‘tissue factor’ (TF). TF is expressed by many tumor cells and contributes to a variety of pathological processes, including thrombosis, metastasis, tumor growth, and tumor angiogenesis. Once the antibody has located the TF receptor, it binds to it, and the cancer-killing payload is able to enter the tumor cell and destroy it from the inside.
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The destruction of a single kind of insulin-producing cell in the pancreas can lead to diabetes — but a study suggests that other cells could be modified to take its place and help to control blood sugar levels.
The results raise hopes that ‘reprogrammed’ insulin-producing cells could be used as treatment for diabetes, but the approach has so far only been tested with human cells in mice studies.
In a study published on 13 February in Nature, researchers report coaxing human pancreatic cells that don’t normally make insulin, a hormone that regulates the amount of glucose in the blood, to change their identity and begin producing the hormone.
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