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Canadian doctors just reversed severe MS using stem cells.

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J147 is an experimental drug that has been shown to treat Alzheimer’s disease, and it also appears to reverse some aspects of aging. It is also poised to enter human clinical trials in the near future, although how it works has been somewhat of a puzzle.

A new study published in the journal Aging Cell has changed all that, and the results are quite intriguing[1]. Researchers at the Salk Institute have solved the mystery of how J147 works and why it makes old flies, mice, and cells more youthful.

Microsoft has built an AI tool that predicts the accuracy of CRISPR so that researchers can avoid making incorrect edits of DNA.

Missing the target: CRISPR uses two components: a cutting protein and a guide RNA that directs it to the part of a genome you want to cut. The guide RNA is about 20 letters long. Problem is, multiple sites in a genome can have the same series of letters, so CRISPR could snip the wrong section—known as an “off target” effect.

Why that matters: Off-target effects are one of the biggest safety concerns with CRISPR. Making incorrect cuts in a genome could, say, switch on a cancer-causing gene.

Continue reading “AI can warn researchers where CRISPR might make a mistake” »

It’s crazy to think that we still don’t quite understand the mechanism behind one of the most common medical interventions — general anaesthetic.

But researchers in Australia just got a step closer by discovering that one of the most commonly used anaesthetic drugs doesn’t just put us to sleep; it also disrupts communication between brain cells.

The team investigated the drug propofol, a super-popular option for surgeries worldwide. A potent sedative, the drug is thought to put us to sleep through its effect on the GABA neurotransmitter system, the main regulator of our sleep-and-wake cycles in the brain.

Continue reading “Scientists Just Changed Our Understanding of How Anaesthesia Messes With The Brain” »

Using stem cells, scientists were able to grow working human muscle in the lab. This could have huge applications in both therapy and research.

TUESDAY, Jan. 9, 2018 — In a potential advance for medical research, scientists say they’ve created the first functioning human muscle from skin cells.

The breakthrough could lead to better genetic or cell-based therapies, as well as furthering investigations into the causes and treatment of muscular disorders, the Duke University team said.

“The prospect of studying rare diseases is especially exciting for us,” Nenad Bursac, professor of biomedical engineering, said in a university news release.

Continue reading “Scientists turn skin cells into muscle cells, a potential boon for research” »

The scientist behind an advanced sex robot has plans for 3D printed offspring. Samantha, developed by Spanish robotics firm Synthea Amatus, went on sale in the United Kingdom last month for around $5,000 — but while the A.I. present in the initial version offers a range of functions like telling jokes, discussing philosophy and synchronizing climaxes, a future version could offer more ambitious features.

“I can make them have a baby. It’s not so difficult. I would love to have a child with a robot,” Sergei Santos, creator of Samatha, told The Sun in a Friday story.

Sex robots are a growing, but controversial, area of artificial intelligence. While some argue that such machines could spark a wider discussion about sexuality, others object to the aim to replicate human interaction. Futurologist Ian Pearson claims that by 2050, more than half of people will have sex with a robot.

Continue reading “Sex Robots That Can Make Babies May Soon Be Available” »

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