Lifeboat Foundation

Stem cells in the brain can divide and mature into neurons participating in various brain functions, including memory. In a paper scientists have discovered that the flow of cerebrospinal fluid is a key signal for neural stem cell renewal.

The ancient Greek aphorism panta rhei means “everything flows”, a phrase used by philosophers to describe the constant flux and interplay between the past and renewal. A recent paper lends this relationship a whole new meaning: a team of researchers headed by Professor Magdalena Götz and their collaborators from the LMU (Professor Benedikt Grothe, Chair of Neurobiology) and the Henrich-Heine University Düsseldorf have discovered that the flow of cerebrospinal fluid is a key signal for neural stem cell renewal.

“Neural stem cells in the brain can divide and mature into neurons and this process plays important roles in various regions of the brain – including olfactory sense and memory,” explains Magdalena Götz, Head of LMU Department of Physiological Genomics and Director of the Institute for Stem Cell Research at Helmholtz Zentrum München. “These cells are located in what is known as the neurogenic stem cell niche one of which is located at the walls of the lateral ventricles, where they are in contact with circulating cerebrospinal fluid.”

Injecting minute amounts of two immune-stimulating agents directly into solid tumors in mice can eliminate all traces of cancer in the animals, including distant, untreated metastases, according to a study by researchers at the Stanford University School of Medicine.

The approach works for many different types of cancers, including those that arise spontaneously, the study found.

The researchers believe the local application of very small amounts of the agents could serve as a rapid and relatively inexpensive cancer therapy that is unlikely to cause the adverse side effects often seen with bodywide immune stimulation.

Continue reading “Cancer ‘vaccine’ eliminates tumors in mice” »

Somewhat paradoxically, euthanasia and life extension share a common goal—ending pointless suffering.

On May 10 this year, Australian ecologist David Goodall took his own life before aging could. The scientist, aged 104, reportedly said he “regretted” having reached that age, because the quality of his life had significantly deteriorated as a consequence of his declining health. Unhappy with his condition, though not suffering from any terminal disease—except for aging itself—Goodall opted to end his life through assisted suicide. As the practice is currently not allowed in Australia, he flew with friends and family all the way to a clinic in Switzerland, where he flipped a switch and administered his own lethal injection while listening to Beethoven’s Ninth Symphony. Interestingly, the cost of his trip to Switzerland was covered with money collected through a crowdfunding campaign.

A matter of rights

Continue reading “The right to die and the right to live” »

Researchers from the National Cancer Institute (NCI), the University of Kansas, and the National Center for Advancing Translational Science (NCATS) have discovered a compound that can block the spread of cancer cells.

Preventing cancer metastasis

Metastasis is how cancer spreads from an initial site to a secondary site within the host’s body; the newly pathological sites, then, are metastases. Metastasis is what makes some cancers so lethal and hard to treat unless they are caught before they spread.

In the air, beneath the ocean’s surface, and on land, microbes are the minute but mighty forces regulating much of the planet’s biogeochemical cycles. To better understand their roles, scientists work to identify these microbes and to determine their individual contributions. While advances in sequencing technologies have enabled researchers to access the genomes of thousands of microbes and make them publicly available, no similar shift has occurred with the task of assigning functions to the genes uncovered.

To help overcome this bottleneck, scientists at Lawrence Berkeley National Laboratory (Berkeley Lab), including researchers at the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), have developed a workflow that enables large-scale, genome-wide assays of gene importance across many conditions. The study, “Mutant Phenotypes for Thousands of Bacterial Genes of Unknown Function,” has been published in the journal Nature and is by far the largest functional genomics study of bacteria ever published.

“This is the first really large, systematic experimental effort to try to assign functions to bacterial genes of unknown function,” said study senior author and biologist Adam Deutschbauer of Berkeley Lab’s Biosciences Area. “We are tackling the problem that biology is up against and recognizes: It is super easy to sequence, but we cannot currently assign confident functions for the majority of genes identified by sequencing. Our experimental data provides an anchor that other researchers could use to make a more informed inference about protein function.”

Continue reading “Exploration of diverse bacteria signals big advance for gene function prediction” »

New York, May 16 (IANS) Older adults with mild cognitive impairment (MCI) who indulge in exergames — video games that are also a form of exercise — may experience significant improvement in complex thinking and memory skills, according to a study.

By Julianna Photopoulos

A laser device can monitor vital signs such as your heartbeat, breathing rate, and muscle activity from up to a metre away. The device is intended for hospital patients or those with chronic diseases who need close monitoring at home. What’s more, it works through your clothes.

“No wires — everything is non-contact — continuously measuring different biomedical parameters with a single sensor,” says Zeev Zalevsky who developed the SmartHealth Mod with his team at ContinUse Biometrics, based …

Continue reading “Laser can detect your heartbeat and breathing from a metre away” »

The first conference on ageing research organised by the Life Extension Advocacy Foundation is coming to New York on July 12th!

We’re extremely excited to announce “Ending Age-Related Diseases: Investment Prospects & Advances in Research”, the very first rejuvenation biotechnology conference that LEAF has organized.

Respected speakers from around the globe

Continue reading “Announcing the ‘Ending Age-Related Diseases’ Conference” »

Recently, roughly 200 eminent scientists assembled in Boston. Their agenda? Creating “superhero” human cells impervious to all viral attacks and possibly other killers—radiation, freezing, aging, or even cancer.

The trick isn’t super-soldier serum. Instead, the team is relying on tools from synthetic biology to read the cell’s genetic blueprint and rewrite large chunks of the genome to unlock these superpowers.

“There is very strong reason to believe that we can produce cells that would be completely resistant to all known viruses,” said Dr. Jef Boeke, a geneticist at New York University and a co-leader of the project. “It should also be possible to engineer other traits, including resistance to prions and cancer.”

Continue reading “Scientists Kick Off Synthetic Biology Project to Make Virus-Resistant Super Cells” »