Check out Synthego’s blog post to explore the possibility of CRISPR aided anti-aging solutions. #aging #genomics #GenomeEngineering https://buff.ly/2Ohmj2F
There is. Our engagement with AI will transform us. Technology always does, even while we are busy using it to reinvent our world. The introduction of the machine gun by Richard Gatling during America’s Civil War, and its massive role in World War I, obliterated our ideas of military gallantry and chivalry and emblazoned in our minds Wilfred Owen’s imagery of young men who “die as Cattle.” The computer revolution beginning after World War II ushered in a way of understanding and talking about the mind in terms of hardware, wiring and rewiring that still dominates neurology. How will AI change us? How has it changed us already? For example, what does reliance on navigational aids like Waze do to our sense of adventure? What happens to our ability to make everyday practical judgments when so many of these judgments—in areas as diverse as credit worthiness, human resources, sentencing, police force allocation—are outsourced to algorithms? If our ability to make good moral judgments depends on actually making them—on developing, through practice and habit, what Aristotle called “practical wisdom”—what happens when we lose the habit? What becomes of our capacity for patience when more and more of our trivial interests and requests are predicted and immediately met by artificially intelligent assistants like Siri and Alexa? Does a child who interacts imperiously with these assistants take that habit of imperious interaction to other aspects of her life? It’s hard to know how exactly AI will alter us. Our concerns about the fairness and safety of the technology are more concrete and easier to grasp. But the abstract, philosophical question of how AI will impact what it means to be human is more fundamental and cannot be overlooked. The engineers are right to worry. But the stakes are higher than they think.
That’s what we are after, with AI. Understanding intelligence in machines, animals and humans, is one of the great scientific challenges of our times and building intelligent machines is one of the greatest technological challenges of our times. No single entity in industry, academia or public research has a monopoly on the good ideas that will achieve these goals. It’s going to take the combined effort of the entire research community to make progress in the science and technology of intelligence.
Facebook is taking an unusual recruitment model championed in law and medicine and applying it to artificial intelligence — and it’s working.
Evolutionary theory predicts that reproduction entails costs that detract from somatic maintenance, accelerating biological aging. Despite support from studies in human and non-human animals, mechanisms linking ‘costs of reproduction’ (CoR) to aging are poorly understood. Human pregnancy is characterized by major alterations in metabolic regulation, oxidative stress, and immune cell proliferation. We hypothesized that these adaptations could accelerate blood-derived cellular aging. To test this hypothesis, we examined gravidity in relation to telomere length (TL, n = 821) and DNA-methylation age (DNAmAge, n = 397) in a cohort of young (20–22 year-old) Filipino women. Age-corrected TL and accelerated DNAmAge both predict age-related morbidity and mortality, and provide markers of mitotic and non-mitotic cellular aging, respectively. Consistent with theoretical predictions, TL decreased (p = 0.031) and DNAmAge increased (p = 0.007) with gravidity, a relationship that was not contingent upon resource availability. Neither biomarker was associated with subsequent fertility (both p 0.3), broadly consistent with a causal effect of gravidity on cellular aging. Our findings provide evidence that reproduction in women carries costs in the form of accelerated aging through two independent cellular pathways.
Wearable medical technology is designed to be small and lightweight to minimize additional burden on medical Airmen and the warfighter, whether they are on a remote battlefield or aboard an aircraft.
“Wearables provide greater accessibility,” said Dr. David Burch, a research biomedical engineer and the medical technology solutions team lead for the En Route Care Medical Technology Solutions Research Group, 711th HPW. “An aircraft has a very tight space and weight limit to maintain performance, and battlefield medics need to carry everything they use. Wearables provide accessibility to the human in a way that is better form, fit, and function.”
One wearable device that achieves that accessibility is a tissue oxygenation sensor, developed jointly with a private company. This small, soft, injectable sensor lets medics determine if a patient is able to be medically evacuated by assessing how well their blood transports oxygen to tissue.
Continue reading “Lighter, leaner, lifesaving: AF tests wearable medical tech” »
Often only a few years separate the tinfoil hats from the millionaires to be. I was writing the piece on the Youbionic arm and thinking of how we will use 3D printing to augment human beings. Clearly augmenting the human body with mechatronics would be a good idea. The flesh is weak but stepper motors are strong! Oh how we will eeck, ooow, brrrr whine in our old stepper augmented age. Machines could very well fill the gaps once our bodies start failing us. But, will old people homes really be filled with Borg grandmas?
Continue reading “Joris Column: Printcrime, augmenting humans, nanoconvergence and Segway polo” »
This is part of our ongoing series of articles that discuss the Hallmarks of Aging. Published in 2013, the paper divides aging into distinct categories (“hallmarks”) of damage to explain how the aging process works and how it causes age-related diseases. Today, we will be looking at the hallmark of cellular senescence.
What are senescent cells?
As you age, increasing numbers of your cells enter into a state known as senescence. Senescent cells do not divide or support the tissues of which they are part; instead, they emit a range of potentially harmful chemical signals that encourage nearby healthy cells to enter the same senescent state. Their presence causes many problems: they reduce tissue repair, increase chronic inflammation, and can even eventually raise the risk of cancer and other age-related diseases.
Like a team in a science fiction movie, the six-lab squad funded by a 2017 MEDx Biomedical research grant is striking in its combination of diverse skills and duties.
The project is led by Kafui Dzirasa, MD’09, Ph.D.’07, HS’10-’16, associate professor of psychiatry and behavioral sciences and assistant professor in neurobiology and neurosurgery; and Nenad Bursac, Ph.D., professor of biomedical engineering and associate professor in medicine. Their team includes: Marc Caron, Ph.D., James B. Duke Professor of Cell Biology, professor in neurobiology and medicine; Fan Wang, Ph.D., professor of neurobiology; Christopher Kontos, MD, HS’93-’97, professor of medicine and associate professor of pharmacology and cancer biology—all at Duke University School of Medicine—and Jennie Leach, Ph.D., associate professor of chemical, biochemical, and environmental engineering at the University of Maryland Baltimore County, along with a cadre of committed graduate students, postdocs, and technicians.
Dzirasa’s background in engineering informs his approach to the study of neuropsychiatric illness and disease. In the summer of 2016, he and members of his lab were discussing the challenge of precisely monitoring brain activity.
