Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: biotech/medical – Page 209

The most common form – obstructive sleep apnoea – happens when the walls of the throat relax and narrow or close, with symptoms including choking noises, loud snoring and waking up a lot.

The three-hour procedure to fit Nyxoah’s Genio implant was carried out by medics at University College London Hospitals NHS foundation trust (UCLH) this month.

One of the two patients, Natalie Boller, 63, was feeling better within days and will return to the clinic to have the device activated in the coming weeks.

Read more | >

Research utilizing AI tool AlphaFold has revealed a new protein complex that initiates the fertilization process between sperm and egg, shedding light on the molecular interactions essential for successful fertilization.

Genetic research has uncovered many proteins involved in the initial contact between sperm and egg. However, direct proof of how these proteins bind or form complexes to enable fertilization remained unclear. Now, Andrea Pauli’s lab at the IMP, working with international collaborators, has combined AI-driven structural predictions with experimental evidence to reveal a key fertilization complex. Their findings, based on studies in zebrafish, mice, and human cells, were published in the journal Cell.

Fertilization is the first step in forming an embryo, starting with the sperm’s journey toward the egg, guided by chemical signals. When the sperm reaches the egg, it binds to the egg’s surface through specific protein interactions. This binding readies their membranes to merge, allowing their genetic material to combine and create a zygote—a single cell that will eventually develop into a new organism.

Read more | >

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links/Affiliates:
Blood testing (where I get the majority of my labs): https://www.ultalabtests.com/partners/michaellustgarten.

At-Home Metabolomics: https://www.iollo.com?ref=michael-lustgarten.
Use Code: CONQUERAGING At Checkout.

Clearly Filtered Water Filter: https://get.aspr.app/SHoPY

Epigenetic, Telomere Testing: https://trudiagnostic.com/?irclickid=U-s3Ii2r7xyIU-LSYLyQdQ6…M0&irgwc=1
Use Code: CONQUERAGING

NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/

Continue reading “Red Light Therapy Improves Eye Function: Glen Jeffery, PhD” | >

PHOENIX — Mayo Clinic announces the results of an innovative treatment approach that may offer improvement in overall survival in older patients with newly diagnosed glioblastoma while maintaining quality of life. Glioblastoma is the most lethal type of primary brain cancer due to its aggressive nature and its treatment-resistant characteristics. It is the most common form of primary brain cancer. Each year an estimated 14,500 people in the U.S. are diagnosed with the disease. Results of Mayo Clinic’s phase 2, single-arm study are published in The Lancet Oncology.

Sujay Vora, M.D., radiation oncologist at Mayo Clinic, led a team of researchers investigating the use of short-course hypofractionated proton beam therapy incorporating advanced imaging techniques in patients over the age of 65 with newly diagnosed World Health Organization (WHO) grade 4, malignant glioblastoma.

Results showed that 56% of participants were alive after 12 months and the median overall survival was 13.1 months.” As compared to prior phase 3 studies in an older population having a median survival of only six to nine months, these results are promising,” says Dr. Vora. “In some cases, patients with tumors that have favorable genetics lived even longer, with a median survival of 22 months. We are very excited about these results.”

Read more | >

Microgravity is known to alter the muscles, bones, the immune system and cognition, but little is known about its specific impact on the brain. To discover how brain cells respond to microgravity, Scripps Research scientists, in collaboration with the New York Stem Cell Foundation, sent tiny clumps of stem-cell derived brain cells called “organoids” to the International Space Station (ISS).

Surprisingly, the organoids were still healthy when they returned from orbit a month later, but the cells had matured faster compared to identical organoids grown on Earth—they were closer to becoming adult neurons and were beginning to show signs of specialization. The results, which could shed light on potential neurological effects of space travel, appear in Stem Cells Translational Medicine.

“The fact that these cells survived in space was a big surprise,” says co-senior author Jeanne Loring, Ph.D., professor emeritus in the Department of Molecular Medicine and founding director of the Center for Regenerative Medicine at Scripps Research. “This lays the groundwork for future experiments in space, in which we can include other parts of the brain that are affected by neurodegenerative disease.”

Read more | >

Pain is meant to be a defense mechanism. It creates a strong sensation to get us to respond to a stimulus and prevent ourselves from further harm. But, sometimes injuries, nerve damage, or infections can cause long-lasting, severe bouts of pain that can make daily life unbearable.

What if there was a way to simply turn off ? UNC School of Medicine researchers Bryan L. Roth, MD, Ph.D., the Michael Hooker Distinguished Professor of Pharmacology, and Grégory Scherrer, PharmD, Ph.D., associate professor of cell biology and physiology and the UNC Neuroscience Center, have just proven that it is possible.

Using a tool designed by Roth in the early 2000s, the labs have created a new system that reduces acute and tissue-injury-induced inflammatory in mouse models. Hye Jin Kang, Ph.D., an alumnus of the Roth Lab and now associate professor at Yonsei University in Korea, was first author on the research paper. The results were published in Cell.

Read more | >

DDW Editor Reece Armstrong speaks to Ellie Mahjubi, Vice President, Protein and cell analysis at Thermo Fisher Scientific, about how spatial biology is impacting drug discovery and development research.

RA: What’s the future and potential for spatial biology?

EM: Technological advancements in spatial biology are providing unprecedented insights into single cells within their spatial context, facilitating the analysis of cell types, functional states, cell interaction networks, as well as tissue microenvironments and architecture. These innovations promise to significantly advance basic research and enhance our understanding of human health and disease.

Read more | >

Researchers have used a chemical compound to light up treatment-resistant cancers on imaging scans, in a breakthrough that could help medical professionals better target and treat cancer.

The authors at King’s College London say that using the radiotracer—an injected compound used in PET scans—could help inform doctors that a patient’s aggressive cancer will not respond to chemotherapy before treatment is given. This would prevent patients receiving unnecessary treatment and provide them with alternative options that will give them the best chance of beating the disease.

The paper, “Imaging NRF2 activation in non-small cell lung cancer with ” published in Nature Communications, shows therapy-resistant tumors “lit up like a Christmas tree” on PET scans when the radiotracer was injected.

Read more | >

Sign up for the Morning Brief email newsletter to get weekday updates from The Weather Channel and our meteorologists.

A powerful earthquake, possibly the strongest in years, has devastated the island nation of Vanuatu, killing at least 14 people. More than 200 are reported injured according to a post on X by Katie Greenwood, Fiji-based head of the Red Cross in the Pacific.

The 7.3-magnitude jolt rocked the region on Tuesday sending tremors through homes, businesses and critical infrastructure. Witnesses described buildings collapsing, roads blocked by landslides and hospitals stretched thin as reports of injuries — and unconfirmed casualties — surfaced.

Read more | >

Dr. Ethell’s groundbreaking research serves as the foundation for Leucadia Therapeutics’ work. A PhD in Neuroscience, he has studied Alzheimer’s disease for 20 years. He was a Human Frontiers of Science Long-term Fellow at the Max Planck Institute for Psychiatry in Germany and a Research Associate at the Scripps Research Institute in La Jolla, California. Dr. Ethell ran Alzheimer’s disease research at the La Jolla Institute for Immunology, served on the faculty at the University of California Riverside, and later founded the Molecular Neurobiology Group at the Western University of Health Sciences in Pomona, California, where he also chaired the Department of Neuroscience. He has authored more than 85 papers and presentations.

The Coalition for Radical Life Extension and Longevity Escape Velocity Foundation are bringing together the best in longevity research with the best in anti-aging and age-reversal practices.
The critical research Aubrey de Grey Ph.D. has curated through his renowned Longevity Summit will now be featured at RAADfest, alongside the most advanced and relevant clinical practices for impacting longevity today. RAADfest is the largest and most immersive event in the world focused on super-longevity for a general audience.

Bringing together cutting-edge science, inspiration, entertainment and fun, RAADfest is more than just a conference – it’s a celebration of life. RAADfest provides the information and inspiration to enable people to take charge of their longevity. Produced by the Coalition for Radical Life Extension, whose mission is to align people, resources and policies to our shared vision of curing aging.
https://www.raadfest.com/

Read more | >