Lifeboat Foundation

Pancreatic cancer is especially challenging to treat—only eight percent of patients are still alive five years after diagnosis. Chemotherapy and radiation therapy are of limited benefit, and even immunotherapy—which revolutionized treatment for other kinds of cancer by activating the body’s immune system to attack cancer cells—has been largely ineffective because pancreatic tumors have ways to dampen the immune assault.

Now, researchers at Washington University School of Medicine in St. Louis and Rush University in Chicago have found a chemical compound that promotes a vigorous immune assault against the deadly cancer. Alone, the compound reduces pancreatic tumor growth and metastases in mice. But when combined with immunotherapy, the compound significantly shrank tumors and dramatically improved survival in the animals.

The findings, published July 3 in Science Translational Medicine, suggest that the immune-boosting compound could potentially make resistant pancreatic cancers susceptible to immunotherapy and improve treatment options for people with the devastating disease.

When I was kid I used to watch the Incredible Hulk on TV and wait for Bruce Banner to fly into a rage, his muscles inflating like balloons, pants torn to shreds while his entire body turns green as he transforms into the Hulk. As I grew up, and learned more about the advances in genetics, it never occurred to me that cutting-edge genome-editing techniques could explain the scientific principles behind the Hulk’s metamorphosis or his fellow Marvel Comics star-spangled hero Captain America. In a recent Stanford Report story, Sebastian Alvarado Opens in a new window, a postdoctoral research fellow in biology, creatively applies the concepts of epigenetics to illuminate the process by which average Joes become superheroes.

As Alvarado notes in the piece Opens in a new window and above video, over the past 70 years scientists have developed tools for selectively activating and deactivating individual genes through chemical reactions, a process termed epigenetics. Similar to flipping on a light, switch gene expression can be “turned on” or “turned off. ”We have a lot of genome-editing tools – like zinc finger nucleases, or CRISPR/Cas9 systems – that could theoretically allow you to epigenetically seek out and turn on genes that make your muscles physically large, make you strategically minded, incredibly fast, or increase your stamina,” he said.

Continue reading “Using epigenetics to explain how Captain America and the Incredible Hulk gained their superpowers” »

You know that spherical ship from 2001: A Space Odyssey that generated its own gravity by spinning around in the cosmic void? We’re not there yet, but we’re getting closer.

Microgravity can be detrimental for the human body, because our species just wasn’t made to survive in space without high-tech help. Now aerospace engineer Torin Clark and his team from CU Boulder are turning the artificial gravity tech from movies like 2001 and The Martian into a reality. While an entire ship that makes its own gravity is still light-years away, the team has managed to design a revolving contraption that could save astronauts from too much zero-G exposure.

Continue reading “This artificial gravity machine is right out of 2001: A Space Odyssey” »

As published in a recent study, researchers have discovered that neural stem cells are impeded by the invasion of T cells, immune cells that are not normally present in the neural stem cell niche.

The neural stem cell niches

Our brains contain neural stem cells (NSCs); like their name suggests, these cells are responsible for the formation of new neurons within the brain. This process, which continues throughout life, is known as neurogenesis. These stem cells live in particular niches, which contain a panoply of different cell types, including stem cells in different phases of development and multiple types of immune cells. However, the researchers discovered a startling fact: the brains of older mice contain many specific immune cells known as T cells, while the brains of younger mice contain very few – and, as the study explains, this is true for humans as well.

Electric generators have a plethora of uses—ranging from automotive to aircraft to microgrids. There is currently a strong desire to reduce the size and increase the efficiency of the devices.

Researchers at Purdue University have come up with an effective way to reduce the size and increase the efficiency of the moderate- to low-power electric generators used in those applications.

A wound rotor synchronous machine contains a field winding—a group of insulated current-carrying coils—on the rotor used to create a rotating magnetic field and regulate the output voltage. Associated with this winding are losses, which generate heat that must be removed from the spinning rotor. Permanent magnets can also be used to generate the magnetic field with much less loss and heat generation, but this approach does not facilitate output voltage regulation.

A machine that speeds up evolution is revolutionizing genome design and selection of designer microbes.

For 50 years, evolutionary theory has emphasized the importance of neutral mutations over adaptive ones in DNA. Real genomic data challenge that assumption.

How can bee stings help in the battle against HIV? Could snake venom be used to treat high blood pressure? Kath Nightingale investigates.