Lifeboat Foundation

With ageing, intrinsic haematopoietic stem cell (HSC) activity decreases, resulting in impaired tissue homeostasis, reduced engraftment following transplantation and increased susceptibility to diseases. However, whether ageing also affects the HSC niche, and thereby impairs its capacity to support HSC function, is still widely debated. Here, by using in-vivo long-term label-retention assays we demonstrate that aged label-retaining HSCs, which are, in old mice, the most quiescent HSC subpopulation with the highest regenerative capacity and cellular polarity, reside predominantly in perisinusoidal niches. Furthermore, we demonstrate that sinusoidal niches are uniquely preserved in shape, morphology and number on ageing. Finally, we show that myeloablative chemotherapy can selectively disrupt aged sinusoidal niches in the long term, which is linked to the lack of recovery of endothelial Jag2 at sinusoids. Overall, our data characterize the functional alterations of the aged HSC niche and unveil that perisinusoidal niches are uniquely preserved and thereby protect HSCs from ageing.

Mark H. says he was abducted by aliens. He clearly remembers awakening one night, unable to move anything but his eyes. He saw flashing lights, heard buzzing sounds, experienced feelings of levitation, and felt electric tingling sensations. Most terrifying were the nonhuman figures he saw by his bed.

Mark believes they were aliens.

Later, he underwent hypnosis to try to recall exactly what had happened to him. Under hypnosis, Mark remembered being whisked through an open window to a large spaceship. He was very frightened when aliens took him into some kind of medical examining room. There he had sex with one of them.

As an experiencer, I believe most claims are real. Whether they were man-made or actual exterrestials or exterrestials that work with us it is still a very common phenomenon. There have been several sightings essentially where even the person’s shoes were the only things left. Looking from common science fiction even it is a possibility that Emelia Airhart was teleported by aliens somewhere in the galaxy and can be referenced from the reports on star trek the tv show. There are several missing people that even today with good forensics that hardly anyone can find and the oddity of it all essentially says that essentially there were no traces left like literally none not even DNA. Looking through police records sure there are cold cases but most are solved but there are several cases that even the highest technologies of forensics have not solved. There are several cold cases all around the globe that were not ordinary ones they were, in fact, alien signs. But eventually, with quantum radar we could scan the entire universe to eventually find traces and digitize them finding a sorta batman style way of like forensics but you would need massive hardware but eventually, you could find them or anything in time. If they found Emelia Airhart they will find anyone else if these exist on this universe or even the multiverse if they physically exist. Then they would actually prove that aliens do actually exist aswell. Really nothing is impossible only improbable. Believing in aliens is not as far fetched as it seems. Most of their technology is science-based anyway it is just exotic physics.

The site of the 1973 alleged abduction is getting a historical marker.

Diabetes is one of the leading health problems in our modern world and requires the careful management of a patient’s insulin levels. New research from Tufts University may make that process a little easier. In mouse tests, the team implanted beta cells that produce more insulin on demand, when they’re activated by blue light.

At the heart of both types of diabetes is insulin, the hormone that regulates blood sugar levels, allowing cells in the body to properly use it as energy. In type I diabetes, beta cells in the pancreas don’t produce enough insulin, sometimes because the immune system destroys those vital beta cells. In type II diabetes, a patient’s cells stop responding to insulin, or the pancreas can’t keep up with demand, meaning blood glucose levels spike to dangerous highs.

Managing the condition requires constant monitoring of blood sugar levels and boosting insulin levels as needed, either by directly injecting the hormone or through drugs that amplify the beta cells’ production of it.

Hypertension, or high blood pressure, is a leading cause of death and disability in the U.S. The Centers for Disease Control and Prevention reports that the majority of people who have heart failure or experience their first stroke or heart attack have hypertension. Even a slight increase in your blood pressure can increase your risk for a stroke or heart attack, if it is persistent. Nonsteroidal anti-inflammatory drugs, such as aspirin, ibuprofen (Motrin, Advil), indomethacin (Indocin) and piroxicam (Feldene), can increase your blood pressure whether or not you already have hypertension.

“There are a number of critical technologies that have to be assessed and tested before we go to Mars,” he told Quirks & Quarks host Bob McDonald.

His short-list includes reusable landers, new space suits, mining gear, water and fuel production plants and safe nuclear power sources that could be used to power habitats and equipment on the red planet.

Continue reading “How we’ll get to Mars — what’s the biggest challenge, money or technology?” »

Researchers at the Spanish National Cancer Research Centre (CNIO) have shown that it is possible to extend the life of mice, without using any gene modifying technologies. The finding is the result of a study launched some years ago that aimed to investigate mice with hyper-long telomeres.

A Maltese scientist working with a group of researchers have found a way to re-activate the human immune system to fight cancer cells that can develop.

Dr. David Saliba is optimistic that their research will pave the way for the development of new therapies to fight cancer.

Together with a group of researchers from the University of Malta and the University of Oxford, Dr. David Saliba has for the last four years researched about how immune system cells communicate with each other, especially when it comes to combating cancer.

Every time you inhale through your nose, olfactory receptors in your nasal passages enable your sense of smell to function. These receptors consist of protein complexes that help you detect chemicals floating in the air.

But research now shows that those types of receptors aren’t only found along your breathing passages. They’re all over the body in a wide variety of organs, and they influence what organs like your liver and intestines are doing.

Added to that, cancer cells possess their own collection of olfactory receptors that affect how they function. And those receptors, some researchers believe, might represent one of cancer’s vulnerabilities – and a key to destroying cancers with scents.