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Category: biotech/medical – Page 1921

Front Microbiol. 2018 Sep 27;9:2338. doi: 10.3389/fmicb.2018.02338. eCollection 2018.

Influenza A virus causes periodic outbreaks and seriously threatens human health. The drug-resistant mutants have shown an epidemic trend because of the abuse of chemical drugs. Aloe polysaccharides (APS) extracted from Aloe vera leaves have evident effects on the therapy of virus infection. However, the activity of APS in anti-influenza virus has yet to be investigated. Here, we refined polysaccharides from A. vera leaf. In vitro test revealed that APS could inhibit the replication of a H1N1 subtype influenza virus, and the most obvious inhibitory effect was observed in the viral adsorption period. Transmission electron microscopy indicated that APS directly interacted with influenza virus particles. Experiments on PR8 (H1N1) virus infection in mice demonstrated that APS considerably ameliorated the clinical symptoms and the lung damage of the infected mice, and significantly reduced the virus loads and mortality.

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Successfully coronavirus treatment on a critically ill 71-year woman.

Thai doctors have declared the use of anti-flu and AIDS drugs a success in reducing symptoms of coronavirus patients after using them on a Chinese woman.

Two doctors from Rajavithi Hospital in Bangkok — Dr Kriangsak Atipornwanich, an expert physician, and Assoc Prof Dr Subsai Kongsangdao, a specialist — said at a briefing in Bangkok that improvements were seen in the 71-year-old woman 48 hours after administering the two groups of medications.

The woman was admitted first to Hua Hin Hospital and then transferred to Rajavithi Hospital on Jan 29.

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Scientists from the UNC School of Medicine, Columbia University, and Rockefeller University have revealed the inner workings of one of the most fundamental and important molecular machines in cells.

The researchers, in a study published in Science, used biochemical experiments and cryo– (cryo-EM) to determine the atomic structure of a complex assembly of molecules known as the histone mRNA three-prime (3’) end-processing machine. This machine plays a fundamental role in proper activity and duplication of the cell genome and when defective, it may lead to human diseases, including cancers.

Histone proteins are found in all plants and animals, and they form a “beads-on-a-string” arrangement where the DNA in chromosomes is wrapped around the beads of histones. Histones ensure the efficient packaging of DNA and help regulate which genes are turned “on” and which are kept “off,” processes needed for all cells to function properly.

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Extreme cold is being utilized to bring humans back from the brink of death; after being shot or stabbed and losing half of your blood there is only a 5% chance for survival, but this experimental procedure may help to increase these dire odds.

It is not unheard of for victims of cold water drownings to be successfully resuscitated, this led to Mads Gilbert coining the phrase “nobody is dead until warm and dead” after resuscitating a woman who fell through ice and her temperature dropped to 13.7C. Incidents such as these also raise questions about the likelihood of the science of cold helping to bring humans back from the brink of death.

Trauma surgeon Samuel Tisherman is putting the science of cold to the test, rather than warm patients up he is cooling them down. In 2019 a patient was placed into suspended animation for the first time by Tisherman and his team at the University of Maryland School of Medicine. The procedure described in New Scientist details how the patient was rapidly cooled down to 10-15C which temporarily stopped vital functions to put the patient into a state somewhere between life and death. The team was investigating whether stimulating the same situation as drowning in cold water in a hospital setting could help patients.

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A recent study by MIT found a low-pitched buzz-like sound and strobe lights can be used to replicate brain waves impeded by Alzheimer’s, which improved cognitive function and helped remove plaque in mice displaying symptoms of the disease. The approach hasn’t been tested in humans yet, but if it’s possible to copy these results, it might turn into a drug-free, inexpensive way to treat this condition.

The Secret: Applying Sound and Light at the Same Frequency

The study in question follows up on a previous one, which showed that flashing light and playing sound 40 times a second into the eyes of mice with Alzheimer’s, improved their condition. According to MIT researcher Li-Huei Tsai, there is substantial reduction of amyloid protein and increased prefrontal cortex engagement when visual and auditory stimulation is combined over a period of one week. The prefrontal cortex is the part of the brain most active in cognitive functions.

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A massive, decade-long study sequencing the genomes of dozens of cancers has revealed the secrets of how tumours form and may pave the way for better and more targeted treatment.

The Pan-Cancer Project brought together over 1,300 researchers globally to tackle the mammoth task of sequencing the genomes of 38 types of cancer in nearly 2,800 patients.

Their work produced a host of new discoveries — from the number and location of so-called driver mutations that push cells to reproduce uncontrollably, to the surprising similarities between cancers found in different types of tissue.

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