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Category: biotech/medical – Page 1,859
Engineering Cyborg Bacteria Through Intracellular Hydrogelation
Synthetic biology has made major strides towards the holy grail of fully programmable bio-micromachines capable of sensing and responding to defined stimuli regardless of their environmental context. A common type of bio-micromachines is created by genetically modifying living cells.[ 1 ] Living cells possess the unique advantage of being highly adaptable and versatile.[ 2 ] To date, living cells have been successfully repurposed for a wide variety of applications, including living therapeutics,[ 3 ] bioremediation,[ 4 ] and drug and gene delivery.[ 5, 6 ] However, the resulting synthetic living cells are challenging to control due to their continuous adaption and evolving cellular context. Application of these autonomously replicating organisms often requires tailored biocontainment strategies,[ 7-9 ] which can raise logistical hurdles and safety concerns.
In contrast, nonliving synthetic cells, notably artificial cells,[ 10, 11 ] can be created using synthetic materials, such as polymers or phospholipids. Meticulous engineering of materials enables defined partitioning of bioactive agents, and the resulting biomimetic systems possess advantages including predictable functions, tolerance to certain environmental stressors, and ease of engineering.[ 12, 13 ] Nonliving cell-mimetic systems have been employed to deliver anticancer drugs,[ 14 ] promote antitumor immune responses,[ 15 ] communicate with other cells,[ 16, 17 ] mimic immune cells,[ 18, 19 ] and perform photosynthesis.
Quantifying Biological Age: Blood Test #1 in 2023
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Green Tea Discount Link.
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Bristle Discount Link (Oral Microbiome Quantification):
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https://www.bmq30trk.com/4FL3LK/GTSC3/
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Scientists solve long-standing mystery about mRNAs
Messenger RNAs (mRNAs) contain chemical marks that are critical for antiviral defense in cells, according to a new study from researchers at Weill Cornell Medicine. The finding solves a 50-year mystery concerning the purpose of these chemical modifications, and suggests that faulty mRNA modification may underlie some autoimmune and inflammatory disorders.
Ideal blood pressure may remodel brain clearance pathways linked to brain health, dementia
𝐈𝐝𝐞𝐚𝐥 𝐛𝐥𝐨𝐨𝐝 𝐩𝐫𝐞𝐬𝐬𝐮𝐫𝐞 𝐦𝐚𝐲 𝐫𝐞𝐦𝐨𝐝𝐞𝐥 𝐛𝐫𝐚𝐢𝐧 𝐜𝐥𝐞𝐚𝐫𝐚𝐧𝐜𝐞 𝐩𝐚𝐭𝐡𝐰𝐚𝐲𝐬 𝐥𝐢𝐧𝐤𝐞𝐝 𝐭𝐨 𝐛𝐫𝐚𝐢𝐧 𝐡𝐞𝐚𝐥𝐭𝐡, 𝐝𝐞𝐦𝐞𝐧𝐭𝐢𝐚
𝘾𝙡𝙤𝙨𝙚 𝙧𝙚𝙫𝙞𝙚𝙬 𝙤𝙛 𝙈𝙍𝙄 𝙨𝙘𝙖𝙣𝙨 𝙛𝙤𝙪𝙣𝙙 𝙢𝙤𝙧𝙚 𝙞𝙣𝙩𝙚𝙣𝙨𝙞𝙫𝙚 𝙝𝙞𝙜𝙝 𝙗𝙡𝙤𝙤𝙙 𝙥𝙧𝙚𝙨𝙨𝙪𝙧𝙚 𝙩𝙧𝙚𝙖𝙩𝙢𝙚𝙣𝙩 (𝙩𝙖𝙧𝙜𝙚𝙩𝙚𝙙 𝙩𝙤 𝙖𝙘𝙝𝙞𝙚𝙫𝙚 𝙖 𝙨𝙮𝙨𝙩𝙤𝙡𝙞𝙘 𝙥𝙧𝙚𝙨𝙨𝙪𝙧𝙚 𝙡𝙚𝙨𝙨 𝙩𝙝𝙖𝙣 120 𝙢𝙢 𝙃𝙜) 𝙬𝙖𝙨 𝙢𝙤𝙧𝙚 𝙚𝙛𝙛𝙚𝙘𝙩𝙞𝙫𝙚 𝙩𝙝𝙖𝙣 𝙖 𝙡𝙚𝙨𝙨-𝙞𝙣𝙩𝙚𝙣𝙨𝙚 𝙩𝙧𝙚𝙖𝙩𝙢𝙚𝙣𝙩 𝙜𝙤𝙖𝙡 𝙤𝙛 140 𝙢𝙢 𝙃𝙜 𝙨𝙮𝙨𝙩𝙤𝙡𝙞𝙘 𝙞𝙣 𝙖𝙘𝙝𝙞𝙚𝙫𝙞𝙣𝙜 𝙖 𝙥𝙤𝙨𝙞𝙩𝙞𝙫𝙚 𝙨𝙩𝙧𝙪𝙘𝙩𝙪𝙧𝙖𝙡 𝙘𝙝𝙖𝙣𝙜𝙚 𝙞𝙣 𝙩𝙝𝙚 𝙗𝙧𝙖𝙞𝙣’𝙨 𝙥𝙚𝙧𝙞𝙫𝙖𝙨𝙘𝙪𝙡𝙖𝙧 𝙨𝙥𝙖𝙘𝙚𝙨: 𝙥𝙖𝙩𝙝𝙬𝙖𝙮𝙨 𝙩𝙝𝙖𝙩 𝙖𝙧𝙚 𝙞𝙢𝙥𝙤𝙧𝙩𝙖𝙣𝙩 𝙩𝙤 𝙘𝙡𝙚𝙖𝙧𝙞𝙣𝙜 𝙩𝙤𝙭𝙞𝙣𝙨 𝙖𝙣𝙙 𝙤𝙩𝙝𝙚𝙧 𝙗𝙮𝙥𝙧𝙤𝙙𝙪𝙘𝙩𝙨.
𝙄𝙛 𝙩𝙝𝙚 𝙗𝙧𝙖𝙞𝙣 𝙘𝙖𝙣𝙣𝙤𝙩 𝙥𝙧𝙤𝙥𝙚𝙧𝙡𝙮 𝙘𝙡𝙚𝙖𝙧 𝙢𝙚𝙩𝙖𝙗𝙤𝙡𝙞𝙘 𝙗𝙮𝙥𝙧𝙤𝙙𝙪𝙘𝙩𝙨, 𝙩𝙝𝙚𝙮 𝙖𝙘𝙘𝙪𝙢𝙪𝙡𝙖𝙩𝙚 𝙖𝙣𝙙 𝙢𝙖𝙮 𝙘𝙤𝙣𝙩𝙧𝙞𝙗𝙪𝙩𝙚 𝙩𝙤 𝙩𝙝𝙚 𝙙𝙚𝙫𝙚𝙡𝙤𝙥𝙢𝙚𝙣𝙩 𝙤𝙛 𝙙𝙚𝙢𝙚𝙣𝙩𝙞𝙖, 𝙧𝙚𝙨𝙚𝙖𝙧𝙘𝙝𝙚𝙧𝙨 𝙨𝙖𝙞𝙙.
Embargoed until 4 a.m. CT/5 a.m. ET, Thursday, Feb. 2, 2023
(NewMediaWire) — February 2, 2023 — DALLAS Among people who received more intensive treatment for high blood pressure, evaluations of MRI scans indicated a positive change in brain structures involved in its ability to clear toxins and other byproducts, according to preliminary research to be presented at the American Stroke Association’s International Stroke Conference 2023. The meeting, held in person in Dallas and virtually, Feb. 8–10, 2023, is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health.
The study is the first to examine whether intensive blood pressure treatment may slow, or reverse structural changes related to the volume of the brain’s perivascular spaces, areas of the brain around the blood vessels that are involved in the clearance of toxins and other byproducts. These areas tend to enlarge as people get older or have more cardiovascular risk factors.
Clinical trials show encouraging safety profile for brain-computer interface turning thoughts into action
PROVIDENCE, R.I. [Brown University] — More than two decades ago, a team of Brown University researchers set out with an ambitious goal to provide people with paralysis a revolutionary neurotechnology capable of turning thoughts about movement into actual action, using a tiny device that would one day be implanted in the surface of the brain. Their work led to an ongoing, multi-institution effort to create the BrainGate brain-computer interface, designed to allow clinical trial participants with paralysis to control assistive devices like computers or robotic limbs just by thinking about the action they want to initiate.
Open Access Paper:
https://n.neurology.org/content/early/2023/01/13/WNL.
In an important step toward a medical technology that could help restore independence of people with paralysis, researchers find the investigational BrainGate neural interface system has low rates of associated adverse events.
Exploring the Inner Workings of Human Cells — Database of 200,000 Cell Images Yields New Mathematical Framework
Working with hundreds of thousands of high-resolution images, researchers from the Allen Institute for Cell Science, a division of the Allen Institute, put numbers on the internal organization of human cells — a biological concept that has proven incredibly difficult to quantify until now.
The scientists also documented the diverse cell shapes of genetically identical cells grown under similar conditions in their work. Their findings were recently published in the journal Nature.
“The way cells are organized tells us something about their behavior and identity,” said Susanne Rafelski, Ph.D., Deputy Director of the Allen Institute for Cell Science, who led the study along with Senior Scientist Matheus Viana, Ph.D. “What’s been missing from the field, as we all try to understand how cells change in health and disease, is a rigorous way to deal with this kind of organization. We haven’t yet tapped into that information.”
China claims success in milking cloning tech : 3 ‘super cows’ born
When grown the cows can generate 18 tons of milk per year.
Three “super cows” that can produce an unusually high amount of milk have been cloned by Chinese scientists, according to an article by the Chinese state-run media Global Times.
The new animals will reduce the nation’s dependence on imported breeds, claimed the Wednesday report.
Gene editing company plans to resurrect the dodo
Colossal Biosciences, a genetic engineering company focused on de-extincting past species, has announced $150 million in Series B funding, which it plans to use for bringing back the iconic dodo.
The resurrection of several extinct species is predicted to occur within the next five years. One company aiming to make that a reality is Texas-based startup Colossal Biosciences, founded in 2021 by some of the world’s leading experts in genomics. In May 2022, it appeared in the World Economic Forum’s list of Technology Pioneers and it won Genomics Innovation of the Year at the BioTech Breakthrough Awards.
Scientists develop new device to detect brain tumors using urine
𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡𝐞𝐫𝐬 𝐚𝐭 𝐍𝐚𝐠𝐨𝐲𝐚 𝐔𝐧𝐢𝐯𝐞𝐫𝐬𝐢𝐭𝐲 𝐢𝐧 𝐉𝐚𝐩𝐚𝐧 𝐡𝐚𝐯𝐞 𝐮𝐬𝐞𝐝 𝐚 𝐧𝐞𝐰 𝐝𝐞𝐯𝐢𝐜𝐞 𝐭𝐨 𝐢𝐝𝐞𝐧𝐭𝐢𝐟𝐲 𝐚 𝐤𝐞𝐲 𝐦𝐞𝐦𝐛𝐫𝐚𝐧𝐞 𝐩𝐫𝐨𝐭𝐞𝐢𝐧 𝐢𝐧 𝐮𝐫𝐢𝐧𝐞 𝐭𝐡𝐚𝐭 𝐢𝐧𝐝𝐢𝐜𝐚𝐭𝐞𝐬 𝐰𝐡𝐞𝐭𝐡𝐞𝐫 𝐭𝐡𝐞 𝐩𝐚𝐭𝐢𝐞𝐧𝐭 𝐡𝐚𝐬 𝐚 𝐛𝐫𝐚𝐢𝐧 𝐭𝐮𝐦𝐨𝐫. 𝐓𝐡𝐢𝐬 𝐩𝐫𝐨𝐭𝐞𝐢𝐧 𝐜𝐨𝐮𝐥𝐝 𝐛𝐞 𝐮𝐬𝐞𝐝 𝐭𝐨 𝐝𝐞𝐭𝐞𝐜𝐭 𝐛𝐫𝐚𝐢𝐧 𝐜𝐚𝐧𝐜𝐞𝐫, 𝐚𝐯𝐨𝐢𝐝𝐢𝐧𝐠 𝐭𝐡𝐞 𝐧𝐞𝐞𝐝 𝐟𝐨𝐫 𝐢𝐧𝐯𝐚𝐬𝐢𝐯𝐞 𝐭𝐞𝐬𝐭𝐬, 𝐚𝐧𝐝 𝐢𝐧𝐜𝐫𝐞𝐚𝐬𝐢𝐧𝐠 𝐭𝐡𝐞 𝐥𝐢𝐤𝐞𝐥𝐢𝐡𝐨𝐨𝐝 𝐨𝐟 𝐭𝐮𝐦𝐨𝐫𝐬 𝐛𝐞𝐢𝐧𝐠 𝐝𝐞𝐭𝐞𝐜𝐭𝐞𝐝 𝐞𝐚𝐫𝐥𝐲 𝐞𝐧𝐨𝐮𝐠𝐡 𝐟𝐨𝐫 𝐬𝐮𝐫𝐠𝐞𝐫𝐲. 𝐓𝐡𝐢𝐬 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐜𝐨𝐮𝐥𝐝 𝐚𝐥𝐬𝐨 𝐡𝐚𝐯𝐞 𝐩𝐨𝐭𝐞𝐧𝐭𝐢𝐚𝐥 𝐢𝐦𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬 𝐟𝐨𝐫 𝐝𝐞𝐭𝐞𝐜𝐭𝐢𝐧𝐠 𝐨𝐭𝐡𝐞𝐫 𝐭𝐲𝐩𝐞𝐬 𝐨𝐟 𝐜𝐚𝐧𝐜𝐞𝐫. 𝐓𝐡𝐞 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐰𝐚𝐬 𝐩𝐮𝐛𝐥𝐢𝐬𝐡𝐞𝐝 𝐢𝐧 𝐀𝐂𝐒 𝐍𝐚𝐧𝐨.
Although early detection of many types of cancer has contributed to the recent increases in cancer survival rates, the survival rate for brain tumors has remained almost unchanged for over 20 years. Partly this is due to their late detection. Physicians often discover brain tumors only after the onset of neurological symptoms, such as loss of movement or speech, by which time the tumor has reached a considerable size. Detecting the tumor when it is still small, and starting treatment as soon as possible, should help to save lives.
One possible sign that a person has a brain tumor is the presence of tumor-related extracellular vesicles (EVs) in their urine. EVs are nano-sized vesicles involved in a variety of functions, including cell-to-cell communication. Because those found in brain cancer patients have specific types of RNA and membrane proteins, they could be used to detect the presence of cancer and its progression.