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Background:Pantoea is a genus within the Enterobacterales whose members encompass free-living and host-associated lifestyles. Despite our growing understanding of the role of mobile genetic elements in the biology, ecology, and evolution of this bacterial group, few Pantoea bacteriophages have been identified and characterized.

https://www.liebertpub.com/doi/10.1089/phage.2019.

Background: Pantoea is a genus within the Enterobacterales whose members encompass free-living and host-associated lifestyles. Despite our growing understanding of the role of mobile genetic elements in the biology, ecology, and evolution of this bacterial group, few Pantoea bacteriophages have been identified and characterized.

Materials and Methods: A bacteriophage that could infect Pantoea agglomerans was isolated from barnyard soil. We used electron microscopy and complete genome sequencing to identify the viral family, and evaluated its host range across 10 different Pantoea species groups using both bacterial lawn and phage lawn assays. The latter assays were carried out using a scalable microplate assay to increase throughput and enable spectrophotometric quantitation. We also performed a phylogenetic analysis to determine the closest relatives of our phage.

Results: Phage vB_PagP-SK1 belongs to the genus Teseptimavirus of the Podoviridae family in the order Caudovirales. The 39,938 bp genome has a modular structure with early, middle, and late genes, along with the characteristic direct terminal repeats of 172 bp. Genome composition and synteny were similar to that of the Erwinia amylovora phage, vB_EamP-L1, with the exception of a few loci that are most similar to genes of phage infecting other members of the Enterobacteriaceae. A total of 94 Pantoea strains were surveyed and vB_PagP-SK1 was found to infect 15 Pantoea strains across three species, predominantly P. agglomerans, along with one Erwinia billingiae strain.

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Behind all this doom and gloom, the current COVID-19 viral threat, dreaded climate disasters and feared robocalypse, it’s hard to see a bigger and amazingly brighter picture. Are we evolving into a new species with hybrid thinking, interlinked into the Global Mind? Once our neocortices are seamlessly connected to the Web, what will that feel like to step up one level above human consciousness to global consciousness? Any crisis, including the current one, is an opportunity to transcend the quagmire of status quo.

Are we evolving into a new species with hybrid thinking, interlinked into the Global Mind? At what point may the Web become self-aware? Once our neocortices are seamlessly connected to the Web, how will that feel like to step up one level above human consciousness to global consciousness?

In his book “The Global Brain” (2000) Howard Bloom argues that hyperconnected humans and machines resemble a lot the neurons of the “global brain,” and the coming Internet of Things (IoT) with trillions of sensors around the planet will become effectively the nervous system of Earth. According to the Gaia hypothesis by James Lovelock, we have always been an integral part of this “Meta-Mind,” collective consciousness, global adaptive and self-regulating system while tapping into vast resources of information pooling and at the same time having a “shared hallucination,” we call reality.

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“These findings reveal how the immune system goes awry during coronavirus infections, leading to severe disease, and point to potential therapeutic targets,” said Bali Pulendran, Ph.D., professor of pathology and of microbiology and immunology and the senior author of the study, which will be published Aug. 11 in Science.

Lead authorship is shared by Stanford postdoctoral scholars Prabhu Arnunachalam, Ph.D., and Florian Wimmers, Ph.D.; and Chris Ka Pun Mok, Ph.D., and Mahen Perera, Ph.D., both assistant professors of public health laboratory sciences at the University of Hong Kong.

A Stanford study shows that in severely ill COVID-19 patients, “first-responder” immune cells, which should react immediately to signs of viruses or bacteria in the body, instead respond sluggishly.

Some people get really sick from COVID-19, and others don’t. Nobody knows why.

Now, a study by investigators at the Stanford University of Medicine and other institutions has turned up immunological deviations and lapses that appear to spell the difference between severe and mild cases of COVID-19.

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Instead of recruiting whole phages into phage therapy armies, antibacterial campaigns may simply requisition the organisms’ battle-tested cell-wall-breaching enzymes.

It was 1917 when Felix d’Herelle, at the Institut Pasteur in Paris, first proposed using bacteriophages (or phages)—viruses that infect bacteria—as a therapy for human bacterial infections. Although used for decades in parts of Europe, notably Russia, Poland, and the Republic of Georgia, phage therapy is only permitted in the United States under the “compassionate use” umbrella—when there is nothing else available.

The rise of multidrug-resistant bacteria that defy traditional antibiotics has forced clinicians to seek alternative measures to curb deadly infections. Two cases made headlines in recent years. In 2016, the life of Thomas Patterson, PhD, a professor of psychiatry at the University of California, San Diego, was saved by phage therapy after he developed a deadly Acinetobacter baumannii infection. (The story is recounted in The Perfect Predator, the book that Patterson co-authored with his wife, epidemiologist Steffanie A. Strathdee, PhD.) Last year, the life of an English teenager was saved after she developed an infection following a lung transplant for cystic fibrosis.

Lysins, phage enzymes that can undermine bacterial cell walls, have enormous potential as therapeutics. They may even race ahead of therapies that rely on whole phages, which may arouse resistance.

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Our mindset is everything: what one person sees as a crisis, another person sees as opportunity.

The magnitude of economic and social disruption caused by COVID-19 (25% of small businesses have closed, bankruptcies are up 26%) means that many existing business models are being upended. In some cases, entire industries.

As an entrepreneur, you should be asking yourself: What challenges or problems can I solve? What are new digital business models I want to experiment with?

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The high demand on medical devices and personal protective equipment (PPE) during the COVID-19 crisis left millions of health care professionals unprotected in the middle of this situation, as governments around the world were not prepared for such pandemic. The three-dimensional printing (3DP) community, from universities to 3DP enthusiasts with printers at home, was there to support hospitals from day 1 on this demand by providing PPE and other medical supplies (e.g., face shields and valves for respiratory machines). This editorial covers the importance of 3DP in the fight against COVID-19 and how this can be used to tackle potential pandemics and support the supply chain.

After a series of cases of pneumonia in Wuhan, the capital city of Hubei province (China), the Chinese health authorities announced in January 2020 that a novel coronavirus, officially known as severe acute respiratory syndrome coronavirus (SARS-CoV)-2, was responsible for these cases.1 SARS-CoV-2, the virus that causes the coronavirus disease (COVID-19), was not detected before the recent pandemic and has been known to be genetically similar to SARS-CoV.1 The COVID-19 is transmitted mainly through contact with an infected individual, through droplets that are produced when the patient coughs or sneezes or through droplets from the saliva or nasal cavity.1,2 To avoid transmission, it is very important to implement individual hygiene measures and especially the use of personal protective equipment (PPE). However, the lack of PPE and other key resources during the COVID-19 crisis has been a constant problem, leaving many health care professionals across the world unprotected.

Dealing with a pandemic, such as COVID-19, is an unprecedented situation in this modern globalized word, which has created extraordinary emergency that is particularly affecting the supply chain.3 The supply chain disruptions, in combination with the enormous needs for medical devices and protective health care material, have created the need of new initiatives and the use of emerging technologies such as three-dimensional printing (3DP) to come forward and support the health care professionals and supply chain.

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Israeli hospitals were among the first anywhere to use dexamethasone, a steroid drug, to stop cytokines storms and reduce lung inflammation in severely ill Covid-19 patients. However, steroids can suppress the immune response too strongly.

Additionally, an Israeli hospital is among the first to do a randomized, double-blind, placebo-controlled clinical trial of ivermectin, a drug to treat parasitic infections in people and animals, to see if it can shorten the duration of the disease if given to Covid-19 patients immediately after diagnosis.

Below we summarize 13 potential Israeli treatments using a variety of approaches – such as placenta-derived cells, peptides, blood plasma of recovered patients, and the cannabis compound CBD.

Scientists across the globe are working on vaccines to prevent Covid-19 infection. (Click here to read about six Israeli vaccine candidates.)

But in the meanwhile, and even after initial vaccines are approved, there is an urgent need for effective treatments for the respiratory disease caused by the SARS-CoV-2 coronavirus.

Continue reading “13 promising Covid treatments emerging from Israel” | >

No, dear Pope Francis. I 100% share the concept of the brotherhood of all humans. There can never be too many calls for brotherhood. What I do not share in the most absolute way is that it is “useless to go to the Moon, if we are not brothers on Earth”. Quite opposite: eight billion humans, closed on the surface of our mother planet, will not be able to be brothers unless they will achieve new resources, new spaces, a new horizon of development. Remaining confined to the ground we would find ourselves competing in a zero sum game, or worse, an increasingly negative sum game, considering how much the resources of planet Earth, especially the environmental ones, are already scarce. Once again, it is up to people of good will to refuse to remain and fight among brothers and sisters, and to resume the courageous path of exploration, the search for new resources, the opening of new frontiers and human settlement in space. Properly in order to nourish the many brothers and sisters in peace, harmony and freedom. Otherwise mafias, tyrannies, selfishness, fratricide and infanticide will prevail, as history unfortunately testifies, every time a world has become small and suffocating. Pandemics such as covid19 also teach us that we will be more and more forced into immobility in our homes, if we will insist on remaining in increasing numbers in a philosophically and physically closed world. Let alone “grow and multiply”. Now, from a Jesuit Pope I would have expected at least that he would not run into the most obvious clichés, like “before going into space we must solve problems on Earth”. Quite the contrary: if we will not urgently kick-off the civil expansion into space, not only will we not be able to solve Earth’s problems, but they will get worse and worse, bringing civilization to a very dangerous point of no return.

The Feast of the Assumption of Mary into Heaven coincides with August 15th. Bergoglio remembers those who do not have the opportunity to celebrate. And on the issue of the Nile between Egypt, Ethiopia and Sudan he calls for dialogue and brotherhood.

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