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Category: biotech/medical – Page 1,754

BPA-like chemicals likely causing “alarming” damage to brain cells

Controversy has shrouded the once-common plasticizer BPA since studies started to highlight its links to a whole range of adverse health effects in humans, but recent research has also shown that its substitutes mightn’t be all that safe either. A new study has investigated how these compounds impact nerve cells in the adult brain, with the authors finding that they likely permanently disrupt signal transmission, and also interfere with neural circuits involved in perception.

BPA, or bisphenol A, is a chemical that has been commonly used in food, beverage and other types of packaging for decades, but experts have grown increasingly concerned that it can leech into these consumables and impact human health in ways ranging from endocrine dysfunction to cancer. This came on the back of scientific studies revealing such links dating back to the 1990s, which in turn saw the rise of “BPA-free” plastics as a safer alternative.

One of those alternatives is bisphenol S (BPS), and while it allows plastic manufacturers to slap a BPA-free label on their packaging, more and more research is demonstrating that it mightn’t be much better for us. As just one example, a study last year showed through experiments on mice that just like BPA, BPS can alter the expression of genes in the placenta and likely fundamentally disrupt fetal brain development.

AgeX Discussion of Paper on Protocadherins, Aging, and Regeneration

Click on photo to start video.

Michael D. West talking about regeneration.

[Reuploaded from Vimeo: https://vimeo.com/522148118]

In this video, Dr. Michael West, CEO of AgeX Therapeutics, discusses the non-peer reviewed preprint article in bioRxiv on the potential role of the clustered protocadherin genes in regeneration, aging, and cancer, and the relevance of the discovery for iTR product development.

Full paper: https://www.biorxiv.org/content/10.1101/2021.03.07.434314v1.full.

https://www.agexinc.com.

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Lab discovers titanium-gold alloy that is four times harder than most steels

Circa 2016 o,.o.

Titanium is the leading material for artificial knee and hip joints because it’s strong, wear-resistant and nontoxic, but an unexpected discovery by Rice University physicists shows that the gold standard for artificial joints can be improved with the addition of some actual gold.

“It is about 3–4 times harder than most steels,” said Emilia Morosan, the lead scientist on a new study in Science Advances that describes the properties of a 3-to-1 mixture of and gold with a specific atomic structure that imparts hardness. “It’s four times harder than pure titanium, which is what’s currently being used in most dental implants and replacement joints.”

Morosan, a physicist who specializes in the design and synthesis of compounds with exotic electronic and magnetic properties, said the new study is “a first for me in a number of ways. This compound is not difficult to make, and it’s not a new material.”

Hearing AIDS for the Masses

Imagine Apple, Bose or other consumer electronics companies making hearing aids more stylish and relatively affordable — with people having confidence that the devices had been vetted by the F.D.A. Bose told me that it’s working on over-the-counter hearing aid technology.

This article is part of the On Tech newsletter. You can sign up here to receive it weekdays.

On Tech is back from a spring break, and the magnolia trees are blooming outside On Tech headquarters (a.k.a., my New York apartment).

Today, let’s talk about relatively simple technology and a change in government policy that could unleash more innovation for Americans who have difficulty hearing.

First GMO Mosquitoes to Be Released In the Florida Keys

This spring, the biotechnology company Oxitec plans to release genetically modified (GM) mosquitoes in the Florida Keys. Oxitec says its technology will combat dengue fever, a potentially life-threatening disease, and other mosquito-borne viruses — such as Zika — mainly transmitted by the Aedes aegypti mosquito.

While there have been more than 7300 dengue cases reported in the United States between 2010 and 2020, a majority are contracted in Asia and the Caribbean, according to the U.S. Centers for Disease Control and Prevention. In Florida, however, there were 41 travel-related cases in 2020, compared with 71 cases that were transmitted locally.

FLIR Wins DARPA Contract Worth Up to $20.5M to Develop Revolutionary New Protective Fabrics for Chem-Bio Defense

FLIR Systems, Inc. (NASDAQ: FLIR) announced it has won a contract with the Defense Advanced Research Projects Agency (DARPA) to rapidly develop novel fabrics with embedded catalysts and chemistries that can fight and reduce chemical and biological threats upon contact.

The revolutionary fabrics will be incorporated into protective suits and other equipment such as boots, gloves, and eye protection that can be worn by troops on the battlefield, medical experts, healthcare workers, and more. FLIR received $11.2 million in initial funding for the potential five-year effort worth up to $20.5 million, including options.

The goal of DARPA’s Personalized Protective Biosystems (PPB) program is to reduce the substantial weight and physiological burden of current Personal Protective Equipment (PPE) so soldiers and other specialists can better perform their tasks. PPB will combine novel, lightweight protective materials with new prophylactic medical technologies that mitigate chemical and biological threats at vulnerable tissue barriers, notably the eyes, skin and lungs.