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Category: biotech/medical – Page 1,694

Potential fabrication in research images threatens key theory of Alzheimer’s disease

Neuroscientist and physician Matthew Schrag found suspect images in dozens of papers involving Alzheimer’s disease, including Western blots (projected in green) measuring a protein linked to cognitive decline in rats.

The Neuro-Network.

𝐁𝐋𝐎𝐓𝐒 𝐎𝐍 𝐀 𝐅𝐈𝐄𝐋𝐃?

𝘼 𝙣𝙚𝙪𝙧𝙤𝙨𝙘𝙞𝙚𝙣𝙘𝙚 𝙞𝙢𝙖𝙜𝙚 𝙨𝙡𝙚𝙪𝙩𝙝 𝙛𝙞𝙣𝙙𝙨 𝙨𝙞𝙜𝙣𝙨 𝙤𝙛 𝙛𝙖𝙗𝙧𝙞𝙘𝙖𝙩𝙞𝙤𝙣 𝙞𝙣 𝙨𝙘𝙤𝙧𝙚𝙨 𝙤𝙛 𝘼𝙡𝙯𝙝𝙚𝙞𝙢𝙚𝙧’𝙨 𝙖𝙧𝙩𝙞𝙘𝙡𝙚𝙨, 𝙩𝙝𝙧𝙚𝙖𝙩𝙚𝙣𝙞𝙣𝙜 𝙖 𝙧𝙚𝙞𝙜𝙣𝙞𝙣𝙜 𝙩𝙝𝙚𝙤𝙧𝙮

A neuroscience image sleuth finds signs of fabrication in scores of Alzheimer’s articles, threatening a reigning theory of the disease.

Scientists identify ‘bottleneck’ in drug delivery pathways in stem cells

Our bodies have evolved formidable barriers to protect themselves against foreign substances—from our skin, to our cells and every component within the cells, each part of our bodies has protective layers. These defenses, while essential, pose a significant challenge for pharmaceutical drugs and therapies, such as vaccines, that have to bypass multiple barriers to reach their targets.

Although these barriers are vitally important in pharmaceutical science and drug design, much is still unknown about them and how to overcome them.

In a recent study, researchers from Xi’an Jiaotong-Liverpool University and Nanjing University in China, and Western Washington and Emory University in the U.S., shed some light on why the delivery of therapeutics to can be so difficult.

First self-assembling DNA nanomotor runs on electricity

Researchers at the Technical University of Munich (TUM) have developed the world’s first electric nanomotors made of DNA. The self-assembling structures can be activated by an electric charge to spin a ratcheting rotor arm.

The tiny motor was made using a technique called DNA origami. Like its namesake papercraft, the method involves intricately folding strands of DNA into three-dimensional shapes, with past examples including virus traps, immune-evading drug delivery systems, and even microscopic Van Gogh replicas. These structures are made by carefully selecting DNA sequences that will fold and attach to each other in certain ways, so researchers can add specific strands to a solution and let the DNA objects assemble themselves.

For the new study, the team used this process to make a molecular motor out of DNA for the first time. The motor consists of a rotor arm measuring up to 500 nanometers (nm) long, which is mounted on a base about 40 nm high that’s fixed to a glass plate. Wrapped around the tip of the base, just below the rotor, is a platform with several ratcheting obstacles built into its surface, which controls the direction that the rotor can spin.

COVID-19 Rebound after Taking Paxlovid Likely Due to Insufficient Drug Exposure

Paxlovid is the leading oral medication for preventing severe cases of COVID-19 in high-risk individuals. However, symptoms returned in some patients after treatment was completed, prompting the Centers for Disease Control and Prevention (CDC) to issue a health advisory on this so-called “COVID-19 rebound.”

In a study published June 20, 2022 in Clinical Infectious Diseases, researchers at University of California San Diego School of Medicine evaluated one such patient and found their symptom relapse was not caused by the development of resistance to the drug or impaired immunity against the virus. Rather, the COVID-19 rebound appears to have been the result of insufficient exposure to the drug.

One-time HIV treatment on the horizon after gene-editing breakthrough

TEL AVIV, Israel — A one-time vaccine for HIV is a step closer to reality, according to a new study. A team in Israel used gene-editing technology to engineer type B white blood cells, which can trigger the immune system to fight the virus.

Dr. Adi Barzel of Tel Aviv University says this is one of the few times scientists have been able to engineer B cells outside of the human body. Their study finds that B white blood cells spark the immune system to produce more HIV-neutralizing antibodies. Currently, there is no cure for AIDS, which the HIV virus causes.

“Based on this study, we can expect that over the coming years we will be able to produce a medication for AIDS, additional infectious diseases and certain types of cancer caused by a virus, such as cervical cancer, head and neck cancer and more,” Dr. Barzel says in a university release.

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