That the drug can treat patients in hours or days, instead of weeks or months, has sent scientists chasing its mechanism of action.
by
Michael Torrice
Biological organisms have certain useful attributes that synthetic robots do not, such as the abilities to heal, adapt to new situations, and reproduce. Yet molding biological tissues into robots or tools has been exceptionally difficult to do: Experimental techniques, such as altering a genome to make a microbe perform a specific task, are hard to control and not scalable.
Now, a team of scientists at the University of Vermont and Tufts University in Massachusetts has used a supercomputer to design novel lifeforms with specific functions, then built those organisms out of frog cells.
Continue reading “AI-Designed ‘Living Robots’ Crawl, Heal Themselves” »
How did the monstrous giant squid—reaching school-bus size, with eyes as big as dinner plates and tentacles that can snatch prey 10 yards away—get so scarily big?
Today, important clues about the anatomy and evolution of the mysterious giant squid (Architeuthis dux) are revealed through publication of its full genome sequence by a University of Copenhagen-led team that includes scientist Caroline Albertin of the Marine Biological Laboratory (MBL), Woods Hole.
Giant squid are rarely sighted and have never been caught and kept alive, meaning their biology (even how they reproduce) is still largely a mystery. The genome sequence can provide important insight.
The Supreme Court of the U.S. finds John Rockefeller and his Trust guilty of corruption, illegal business practices and racketeering. As a result of this decision, the entire Rockefeller Standard Oil-Trust, the world’s largest corporation of its time, was sentenced to be dismantled. But Rockefeller was already above the Supreme Court and did not care about this decision.
In order to disperse public and political pressure on him and other robber-barons, Rockefeller uses a trick called “philanthropy”, whereby the illegal gains from his robber-practices in the oil business are used to launch the Rockefeller Foundation. This tax haven was used to strategically take over the health care sector in the U.S…
The Rockefeller Foundation was the front organization for a new global business venture of Rockefeller and his accomplices. This new venture was called the pharmaceutical investment business. Donations from the Rockefeller Foundation went only to medical schools and hospitals. These institutions had become missionaries of a new breed of companies: the manufacturers of patented, synthetic drugs.
A, C57BL/6J mice were genetically engineered using CRISPR–Cas9 genomic editing to encode 288L and 330R in mDPP4 on one chromosome (heterozygous, 288/330+/−) or on both chromosomes (homozygous, 288/330+/+). b, Northern blot of mDPP4 mRNA expression. c, Immunohistochemistry (IHC) of mDPP4 protein in the lungs, brain and kidneys of individual C57BL/6J wild-type (WT), 288/330+/− and 288/330+/+ mice. d, Viral titres for MERS-CoV at 3 days post-infection from C57BL/6J WT, 288/330+/− and 288/330+/+ (all n = 4) mice infected with 5 × 105 plaque-forming units (p.f.u.) of the indicated viruses. Bar graphs show means + s.d.
The current threat of avian influenza to the human population, the potential for the reemergence of severe acute respiratory syndrome (SARS)-associated coronavirus, and the identification of multiple novel respiratory viruses underline the necessity for the development of therapeutic and preventive strategies to combat viral infection. Vaccine development is a key component in the prevention of widespread viral infection and in the reduction of morbidity and mortality associated with many viral infections. In this part, coronavirus vaccine, especially SARS-CoV vaccines are mainly discussed.
Coronavirus vaccines can be inactivated coronavirus, live attenuated coronavirus, or S protein-based. Besides, there are still vectored vaccines, DNA vaccines, and combination vaccines against coronaviruses. Vaccines targeting several animal CoVs have been developed, and some have been demonstrated to be efficacious in preventing viral infection. However, a phenomenon of enhanced disease following vaccination has been observed in cats upon infection with feline infectious peritonitis virus following previous infection, vaccination, or passive transfer of antibody. The phenomenon is not fully understood but is believed to be a result of enhanced uptake and spread of the virus through binding of virus-antibody immune complexes to Fc receptors on the surfaces of macrophages; low-titer (subneutralizing) antibodies directed against the S protein are mainly responsible. Although antibody enhancement appears to be limited to feline infectious peritonitis virus among CoVs, similar concerns have been raised with regard to SARS-CoV. Previously infected mice and hamsters are protected from subsequent infection with SARS-CoV in the absence of enhanced disease, and vaccine studies and passive immunoprophylaxis performed with mice and hamsters suggest that previous exposure and the presence of NAbs provide protection.
U.N. Report: Human Trafficking Reaches ‘Horrific’ New Heights : Goats and Soda A new report from the U.N. Office of Drugs and Crime finds that violent conflict is creating new opportunities for traffickers — and children and girls are increasingly targeted.
A molecule produced by the brain that activates the same receptors as marijuana is protective against stress by reducing anxiety-causing connections between two brain regions, Vanderbilt University Medical Center researchers report.
This finding, published today in Neuron, could help explain why some people use marijuana when they’re anxious or under stress. It could also mean that pharmacologic treatments that increase levels of this molecule, known as “2-AG,” in the brain could regulate anxiety and depressive symptoms in people with stress-related anxiety disorders, potentially avoiding a reliance on medical marijuana or similar treatments.
When mice are exposed to acute stress, a break in an anxiety-producing connection between the amygdala and the frontal cortex caused by 2-AG temporarily disappears, causing the emergence of anxiety-related behaviors.
ROCK HILL, South Carolina and REHOVOT, Israel , January 13, 2020 – Today, 3D Systems (NYSE: DDD) and CollPlant Biotechnologies (NASDAQ: CLGN), announced signing a joint development agreement intended to play a pivotal role in advancing and accelerating breakthroughs in the biomedical industry. The collaboration brings together two industry pioneers—3D Systems, renowned for its 3D printing technologies and healthcare expertise; and CollPlant, the developer of proprietary recombinant human collagen (rhCollagen) BioInk technology currently used for 3D bioprinting of tissues and organs. The two companies plan to jointly develop tissue and scaffold bioprinting processes for third party collaborators.
You might call it a giant leap for 3D bioprinting: Human heart cells have been 3D printed on the International Space Station (ISS) and are making their way back to Earth this week inside a SpaceX capsule. The 3D BioFabrication Facility (BFF) was developed by Techshot Inc., a commercial operator of microgravity research and manufacturing equipment, in partnership with nScrypt, a manufacturer of industrial 3D bioprinters and electronics printers.
“Our BFF has the potential to transform human healthcare in ways not previously possible,” said Techshot President and CEO John Vellinger.” We’re laying the foundation for an entire industry in space.”
If you’re wondering why they don’t just print the cells here on Earth, the answer is gravity. When attempting to print with soft, easily flowing biomaterials on Earth, the tissues collapse under their own weight, resulting in little more than a puddle, explained Techshot in a press release. “But when these same materials are used in the microgravity environment of space, the 3D-printed structures maintain their shapes.” The bio-ink used in the space station, consequently, did not contain the scaffolding materials or thickening agents normally required to resist the Earth’s gravitational pull.
