Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 1,590

“More than 100 malaria vaccine candidates have entered clinical trials in recent decades, but none has shown efficacy greater than 75% – until now.” https://www.futuretimeline.net/images/socialmedia/

Researchers led by the University of Oxford have completed a Phase II trial of R21/Matrix-M, a candidate malaria vaccine, which demonstrated an efficacy of 77% over 12-months of follow-up.

In their findings, posted on SSRN/Preprints with The Lancet, they note that their study is the first to reach the World Health Organization’s goal for a vaccine with at least 75% efficacy by 2030. It represents a substantial improvement over the current most effective malaria vaccine, which has shown just 55% efficacy in trials on African children.

The authors conducted a randomised, controlled, double-blind trial at the Clinical Research Unit of Nanoro (CRUN) / Institut de Recherche en Sciences de la Santé (IRSS), in the West African country of Burkina Faso. They recruited 450 participants, aged 5–17 months, from the catchment area of Nanoro, covering 24 villages and a population of 65000 people.

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The most interesting part is a longevity escape velocity answer starting at 12:19 and going to 16:30.

Join Aubrey de Grey, Ph.D., Sergey Young, and Sourav Sinha as they talk about how our understanding of aging has developed in the last two decades. They will discuss:

- 7 Mechanisms of Aging.
- Longevity Escape Velocity.
- Human lifespan extension options we have today.

Aubrey de Grey is a biomedical gerontologist and the Chief Science Officer of the SENS Research Foundation. He is editor-in-chief of the academic journal Rejuvenation Research, author of The Mitochondrial Free Radical Theory of Aging (1999), and co-author of Ending Aging (2007)

Sergey Young is the founder of Longevity Vision Fund, XPRIZE Innovation Board member, one of Top-100 Longevity Leaders, and a Forbes Tech Council contributor.

Continue reading “SERGEY YOUNG — AMA #8: “Aging as an Engineering Problem” with Aubrey de Grey” | >

Fasting is one of those subjects that is widely talked about, in limited circles. Those who have looked cannot but be intrigued and impressed by the claims and results, whilst those who have not, think it borders on madness, and must be bad for you because…well, FOOD!!

So, for those who want a refresher on the science, through to those who have questions they have always been embarrassed to ask, and onwards to all those you want to send this link to, in an attempt to open their eyes…I did a quick guide to what we know, what are just finding out and at the end, the top questions that get asked on the topic.

Hope you enjoy and have a great day.

It is not just what you eat that matters but when you eat it is also something to consider.
Intermittent and prolonged fasting are showing themselves to very much be part of the repertoire to anyone serious about their health and longevity objectives.

If you want to know more about what to eat, watch my video on diet here.

Continue reading “Fasting Questions And Answers” | >

Physics of DNA —“In Each of Us Lies a Message, Its Beginnings Lost in the Mists of Time” | The Daily Galaxy.

“At one time,” writes science-fiction author Dennis E. Taylor in We Are Legion (We Are Bob), “we thought that the way life came together was almost completely random, only needing an energy gradient to get going. But as we’ve moved into the information age, we’ve come to realize that life is more about information than energy. Fire has most of the characteristics of life. It eats, it grows, it reproduces. But fire retains no information. It doesn’t learn; it doesn’t adapt. The five millionth fire started by lightning will behave just like the first. But the five hundredth bacterial division will not be like the first one, especially if there is environmental pressure. That’s DNA. And RNA. That’s life.”

Information has the Ability to Animate Matter

Paul Davies, Arizona State University astrophysicist and Director of the Beyond Center, and author of The Demon in the Machine –How Hidden Webs of Information Are Solving the Mystery of Life offers a similar message to Taylor: information, like energy, has the ability to animate matter.

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With some unfortunate scifi examples.

What is it that gives meaning to your life? Is death necessary to give life meaning? Nicola is not quite convinced of that, and in this episode, he’ll tell you why along with why he’d like a longer life in good health instead.

LIKE WHAT WE DO?
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If you’d like to help us run this show and/or help Lifespan.io end age-related diseases, you can become a Lifespan Hero: https://lifespan.io/hero?source=X10-desc. Your support means the world to us!

SOURCES AND FURTHER READING
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Check out the Dog Aging Project, which is run by cool people trying to give our pets longer, healthy lives:
http://www.dogagingproject.org.

More about life extension in fiction:

Continue reading “Death, life, and meaning walk into a bar… — YouTube” | >

Multi-resistant pathogens are a serious and increasing problem in today’s medicine. Where antibiotics are ineffective, these bacteria can cause life-threatening infections. Researchers at Empa and ETH Zurich are currently developing nanoparticles that can be used to detect and kill multi-resistant pathogens that hide inside our body cells. The team published the study in the current issue of the journal Nanoscale (“Inorganic nanohybrids combat antibiotic-resistant bacteria hiding within human macrophages”).

Antibiotic-resistant bacteria are being swallowed by a human white blood cell. Colorized, scanning electron microscopic (SEM) image. (Image: CDC/NIAID)

In the arms race “mankind against bacteria”, bacteria are currently ahead of us. Our former miracle weapons, antibiotics, are failing more and more frequently when germs use tricky maneuvers to protect themselves from the effects of these drugs. Some species even retreat into the inside of human cells, where they remain “invisible” to the immune system. These particularly dreaded pathogens include multi-resistant staphylococci (MRSA), which can cause life-threatening diseases such as sepsis or pneumonia.

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In February, the researchers introduced a new biomanufacturing platform that can quickly make shelf-stable vaccines at the point of care, ensuring they will not go to waste due to errors in transportation or storage. In its new study, the team discovered that enriching cell-free extracts with cellular membranes — the components needed to made conjugate vaccines — vastly increased yields of its freeze-dried platform.

The work sets the stage to rapidly make medicines that address rising antibiotic-resistant bacteria as well as new viruses at 40000 doses per liter per day, costing about $1 per dose. At that rate, the team could use a 1000-liter reactor (about the size of a large garden waste bag) to generate 40 million doses per day, reaching 1 billion doses in less than a month.

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Congratulations to our winners and thank you to all who participated. Happy DNA Day!

Thank you for making this another successful year! We received many submissions from students in 40 U.S. states, and 30 countries. We would also like to thank the ASHG members who participated in judging the essays.

Continue the celebration: ASHG has even more planned to celebrate DNA Day. See how else you can participate on the celebration page.

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In this nearly 4-hour SPECIAL EPISODE, Rob Reid delivers a 100-minute monologue (broken up into 4 segments, and interleaved with discussions with Sam) about the looming danger of a man-made pandemic, caused by an artificially-modified pathogen. The risk of this occurring is far higher and nearer-term than almost anyone realizes.

Rob explains the science and motivations that could produce such a catastrophe and explores the steps that society must start taking today to prevent it. These measures are concrete, affordable, and scientifically fascinating—and almost all of them are applicable to future, natural pandemics as well. So if we take most of them, the odds of a future Covid-like outbreak would plummet—a priceless collateral benefit.

Rob Reid is a podcaster, author, and tech investor, and was a long-time tech entrepreneur. His After On podcast features conversations with world-class thinkers, founders, and scientists on topics including synthetic biology, super-AI risk, Fermi’s paradox, robotics, archaeology, and lone-wolf terrorism. Science fiction novels that Rob has written for Random House include The New York Times bestseller Year Zero, and the AI thriller After On. As an investor, Rob is Managing Director at Resilience Reserve, a multi-phase venture capital fund. He co-founded Resilience with Chris Anderson, who runs the TED Conference and has a long track record as both an entrepreneur and an investor. In his own entrepreneurial career, Rob founded and ran Listen.com, the company that created the Rhapsody music service. Earlier, Rob studied Arabic and geopolitics at both undergraduate and graduate levels at Stanford, and was a Fulbright Fellow in Cairo. You can find him at www.after-on.

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