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Category: biotech/medical – Page 1,544

Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells

Resistance to current cancer treatments is an important problem that arises through various mechanisms, but one that stands out involves an overexpression of several factors associated with DNA repair. To counteract this type of resistance, different drugs have been developed to affect one or more DNA repair pathways, therefore, to test different compounds of natural origin that have been shown to induce cell death in cancer cells is paramount. Since natural compounds target components of the DNA repair pathways, they have been shown to promote cancer cells to be resensitized to current treatments. For this and other reasons, natural compounds have aroused great curiosity and several research projects are being developed around the world to establish combined treatments between them and radio or chemotherapy. In this work, we summarize the effects of different natural compounds on the DNA repair mechanisms of cancer cells and emphasize their possible application to re-sensitize these cells.

Day by day we are exposed to chemical carcinogens in the environment, ultraviolet (UV) radiation, ionizing radiation, and also those substances produced in our body during cellular metabolism that attack and produce a variety of DNA injuries. Each lesion favors the development of alterations in DNA and chromosomes, which favors oncogenic transformation and tumor progression. In order to reduce the number of changes in the genome and its instability, cells have several pathways of response to damage and DNA repair proteins that eliminate these lesions. DNA adducts, such as those created by alkylating agents, can be cleaved and repaired by base excision repair (BER) or by nucleotide excision repair (NER), depending on whether it is necessary to remove only a nitrogenous base or a nucleotide. Also, O-6-methylguanine-DNA methyltransferase (MGMT), an alkyltransferase, eliminates alkylations.

Gene therapy eyedrops restored a boy’s sight. Similar treatments could help millions

Dr. Alfonso Sabater pulled up two photos of Antonio Vento Carvajal’s eyes. One showed cloudy scars covering both eyeballs. The other, taken after months of gene therapy given through eyedrops, revealed no scarring on either eye.

Antonio, who’s been legally blind for much of his 14 years, can see again.

The teen was born with dystrophic epidermolysis bullosa, a that causes blisters all over his body and in his eyes. But his skin improved when he joined a clinical trial to test the world’s first topical gene therapy. That gave Sabater an idea: What if it could be adapted for Antonio’s eyes?

‘Cocaine sharks’ off Florida may be feasting on dumped bales of drugs

“The other thing we might find is actually this long flow, [this] drip of pharmaceuticals: caffeine, lidocaine, cocaine, amphetamine, antidepressants, birth control — this long slow drift of them from cities into the [ocean] is… starting to hit these animals,” Hird said.

Shark Week show delves into whether sharks off the coast of Florida are coming into contact with the huge quantities of cocaine that get dumped in these waters.

A synthetic biology platform enabling control over aging-associated stress response

Integrated Biosciences, a biotechnology company combining synthetic biology and machine learning to target aging, in collaboration with researchers at the University of California Santa Barbara, today announced a drug discovery platform that enables precise control of the integrated stress response (ISR), a biological pathway that is activated by cells in response to a wide variety of pathological and aging-associated conditions.

A new publication, “Optogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape,” authored by company founders and featured on the cover of Cell Systems describes a technique that triggers the ISR virtually using light and demonstrates how the accumulation of stress over time shifts a cell’s reaction from adaptation to apoptosis (programmed cell death).

“In a very real way, our platform puts cells into a virtual reality, making them experience stress in the absence of physical stressors,” said Maxwell Wilson, Ph.D., a co-founder of Integrated Biosciences and Assistant Professor of Molecular, Cellular, and Developmental Biology at the University of California Santa Barbara.

Advances in Traumatic Brain Injury Biomarkers

Traumatic brain injury (TBI) is increasingly a major cause of disability across the globe. The current methods of diagnosis are inadequate at classifying patients and prognosis. TBI is a diagnostic and therapeutic challenge. There is no Food and Drug Administration (FDA)-approved treatment for TBI yet. It took about 16 years of preclinical research to develop accurate and objective diagnostic measures for TBI. Two brain-specific protein biomarkers, namely, ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein, have been extensively characterized. Recently, the two biomarkers were approved by the FDA as the first blood-based biomarker, Brain Trauma Indicator™ (BTI™), via the Breakthrough Devices Program. This scoping review presents (i) TBI diagnosis challenges, (ii) the process behind the FDA approval of biomarkers, and (iii) known unknowns in TBI biomarker biology.

Where does cancer come from?

We know a lot about cancer, and yet, there is plenty we do not yet know. We do know that some cancers are genetic in nature and a series of changes in key genes can lead to identifiable malignancies down the line. We would certainly want to know what causes cancer in the first place.

Scientists have been trying to replicate the path a cell takes from being normal to becoming pre-cancerous (one of the earliest stages of cancer in which cells become abnormally shaped and sized) for quite some time now. It is a feat that requires human-derived cells to model how cancer comes to be.

Recently, researchers at The Stanford School of Medicine have been able to emulate some of the earliest stages of gastric cancer by starting with gastric organoids (a rudimentary version of the real stomach made from stem-cell-derived gastric cells) that have a single mutation. The study which was published in Nature outlines how the earliest changes in cells could be seen even before the precancerous stage.

Bodybuilding supplement helps prevent Alzheimer’s disease

There’s an exciting new development in the field of Alzheimer’s disease research. Surprisingly, it centers around a common bodybuilding supplement known as HMB. The key to preserving memory and staving off this devastating disease may, in fact, reside in the diet of those pumping iron at the gym.

Researchers from RUSH Medical College have recently revealed that the muscle-enhancing supplement known as beta-hydroxy beta-methylbutyrate (HMB) could hold potential in the fight against Alzheimer’s disease.

The supplement, frequently used by bodybuilders to boost muscle growth and enhance performance, might also aid in memory protection, plaque reduction, and slowing the progression of Alzheimer’s disease.

Social genetic effects: Study suggests your romantic partner’s DNA can influence your own health behaviors

New research provides evidence that an individual’s health behaviors and outcomes are influenced by the genetic makeup of their romantic partner. The findings, published in Behavior Genetics, indicate that your partner’s genetic tendencies can lead to changes in your own weight, smoking habits, or alcohol consumption over time.

The researchers conducted this study to investigate how a person’s partner can affect their health. They aimed to explore the concept of social genetic effects, which refers to the impact of genetic factors in one person’s environment, such as their partner’s genotype, on their own phenotype (observable characteristics or traits).

“I was mainly interested in exploring the combination of social science and genetics,” explained study author Kasper Otten of Utrecht University. “It is evident that behavior is partly genetically influenced, but much of the social sciences does not deal with this biological fact.

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