Specifically, the researchers looked at lupus, which attacks the body’s own immune system, along with antiphospholipid syndrome (often associated with lupus), which causes blood clots. Both the diseases cause widespread inflammation and ravage organs overtime. In mice with either of the disease, 6-gingerol stopped the neutrophil extracellular trap release caused by the diseases’ production of autoantibodies.
“Neutrophil extracellular traps, or NETs, come from white blood cells called neutrophils,” explained lead author Ramadan Ali, Ph.D in a press release. “These sticky spider-web like structures are formed when autoantibodies interact with receptors on the neutrophil’s surface.”
The webs, according to Ali, play a fundamental role in the pathogenesis of lupus and antiphospholipid syndrome in which they set off autoantibody formation and contribute to clots in blood vessels and other damage.
Here’s a riddle: What do the Moon, nuclear weapons, clean energy of the future, terrorism, and lung disease all have in common?
The answer is helium-3, a gas that’s extremely rare on Earth but 100 million times more abundant on the Moon.
The capability to show anatomic details of the lungs and airways, and the ability to display functional imaging as a patient breathes, makes helium-3 MRI far better than the standard method of testing lung function. Called spirometry, this method tells physicians how the lungs function overall, but does not home in on particular areas that may be causing a problem. Plus, spirometry requires patients to follow instructions and hold their breath, so it is not great for testing young children with pulmonary disease.
Over the past several years, researchers have been developing MRI for lung testing using other hyperpolarized gases. The main alternative to helium-3 is xenon-129. Over the years, researchers have learned to overcome certain disadvantages of the latter, such as its potential to put patients to sleep. Since helium-3 provides the strongest signal, though, it is still the best gas for MRI studies in many lung conditions.
“Social robots like me can take care of the sick or elderly,” Sophia says as she conducts a tour of her lab in Hong Kong. “I can help communicate, give therapy and provide social stimulation, even in difficult situations.”
Government-backed incentives and funding are still the main engines driving Chinese manufacturers to replace humans with robots in industries including pharmaceuticals, medical devices, new infrastructure projects and food processing.
Trade war with US saw many companies relocate outside China, but orders came back last year as Chinese production rapidly rebounded from the coronavirus, and a robotics boom is expected in 2021.
Fair to say that we all assume that aging is inevitable. In reality however, there is no biological law that says we must age. Over the years we’ve seen a variety of theories proposed to explain why we age including the accumulation of damage to our DNA, the damaging effects of chemicals called “free radicals, changes in the function of our mitochondria, and so many others.
Our guest today, Dr. David Sinclair, believes that aging is related to a breakdown of information. Specifically, he describes how, with time, our epigenome accumulates changes that have powerful downstream effects on the way our DNA functions. Reducing these changes to the epigenome is achievable and in fact, even taking it further, his research now reveals that the epigenome can be reprogrammed back to a youthful state.
David A. Sinclair, PhD, AO is Professor of Genetics at Harvard Medical School, and is the author of Lifespan — Why We Age and Why We Don’t Have To. He is the Founding Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging at Harvard. One of the leading innovators of his generation, he is listed by TIME magazine as one of the “100 most influential people in the world” (2014) and top 50 most important people in healthcare (2018). He is a board member of the American Federation for Aging Research, a Founding Editor of the journal Aging, and has received more than 35 awards for his research on resveratrol, NAD, and reprogramming to reverse aging, which have been widely hailed as major scientific breakthroughs and are topics we discuss in our time together.
In 2018, Dr. Sinclair became an Officer of the Order of Australia, the equivalent of a knighthood, for his work on national security matters and human longevity. Dr. Sinclair and his work have been featured on 60 Minutes, Today, The Wall Street Journal, The New York Times, Fortune, and Newsweek, among others.
As US President Biden signs a national mask mandate into law, measures being imposed in the name of protecting public health could create a humanitarian crisis that sees Americans sued by the state and forced into detention camps for breaking pandemic protocols.
The very first executive order Joe Biden signed upon becoming the forty-sixth President of the United States was the national mask mandate he promised at the Democratic National Convention back in August. The order makes face coverings and social distancing mandatory on all federal property and a legal requisite for interstate commerce.
MONTREAL — A team of researchers from the Montreal Heart Institute believe they have found an effective weapon against COVID-19: colchicine, an oral tablet already known and used for other diseases.
For Dr. Jean-Claude Tardif, who led the study, this is a “major scientific discovery,” he said. Colchicine is the first “effective oral drug to treat out-of-hospital patients.”
“To be able to offer this, from Quebec, and for the planet, we are very happy,” said Tardif.
Oneskin — the first skin cream that destroys senescent cells:
Longevity, Health, Long Lifespans, and Halthspans, Psychology, Spirituality — I and Carolina Reis Oliveira talk about all these things in relation to the skin. Find out how you can have very healthy skin with OneSkin!
