Lifeboat Foundation

Scientists in Europe have created embryo-like structures that mimic a crucial yet enigmatic stage of human development.

The structures, created from stem cells and called gastruloids, are the first to form a 3D assembly that lays out how the body will take shape. The gastruloids developed rudimentary components of a heart and nervous system, but lacked the components to form a brain and other cell types that would make them capable of becoming a viable fetus.

Researchers are creating ever more sophisticated artificial structures to study embryo development in the lab. The latest method for making these structures, published in Nature today¹, could shed light on the causes of pregnancy loss and early developmental disorders, such as congenital heart conditions and spina bifida.

BioMed Realty, a real estate development firm that specializes in life-sciences and biotech space, is taking over development of a multi-acre site in Somerville’s Assembly Square to create a “best-in-class life science office park.”

BioMed has agreed to acquire an existing office at 5 Middlesex Ave. in Somerville, as well as 7.5 acres of land for future development, from a joint venture of Novaya Real Estate Ventures and Cresset Development. The firms did not disclose terms of the agreement.

BioMed, which investment giant Blackstone acquired in 2016, has a local portfolio spanning 3.5 million square feet, including a number of properties in Cambridge, as well as facilities in Watertown and Boston’s Longwood Medical Area. Its most recent project proposal in Cambridge is for a 16-story office and lab at 585 Third St.

True genetic isolation is hard to pull off. Human populations tend to mix when they are in close proximity.

Consider the Hui people. These are Muslims who live across China and speak the local Chinese dialect of their locale. The Hui claim descent from Central Asians and Persians who arrived in China around 1,000 years ago. But the vast majority of their genomes are no different from the Han Chinese. Physically they are impossible to distinguish from Han Chinese unless you take note of their attire.

How can that be when they are so culturally different? For example, as Muslims the Hui do not eat pork and consider it unclean. In contrast, for the majority Han pork is dietary staple.

Many cultures have found religious experiences with creatures and this soronan desert road has naturally occurring dmt with has actually created many religious organizations for centuries.

Our Vice Mexico team went to the Sonora desert in search of the Bufo Alvarius, an endemic toad species that contains a very high dosage of 5-MEO-DMT in it´s body. 5-MEO-DMT is said to be the most potent hallucinogenic in the world.

Continue reading “Getting High with a Hallucinogenic Toad Prophet” »

Approach to identifying the best drug targets gets critical test.

Researchers in Germany have discovered a new mechanism by which Alzheimer’s disease impairs memory recall – and, importantly, found a way to reverse it in mice. Neurons encoded with existing memories are being drowned out by noise from neurons encoding new experiences, and silencing these allowed the mice to regain lost memories.

The hippocampus is the region of the brain responsible for encoding experiences into memories, by building networks of neurons that store the information. When we recall a previous situation, those same neurons are activated. But when Alzheimer’s strikes, the hippocampus is usually one of the first brain regions to go. This manifests as the familiar memory loss and confusion that patients suffer from.

It was previously thought that the disease impairs the neurons containing memories so that they can’t be activated during recall, and eventually the memory they hold is lost. But the new study, from researchers at the German Center for Neurodegenerative Diseases (DZNE), found a different mechanism at work.

A technological advancement that may prove crucial in the long-term success of dental implants has been developed by University of Queensland researchers.

Dr. Karan Gulati, NHMRC Early Career Fellow from the UQ School of Dentistry, said modifying dental implants with ‘nanopores’ will help protect against one of the leading causes of implant failure.

“Poor integration between the implant and the surrounding tissue is one of the leading causes of dental implant failure,” Dr. Gulati said. “If the sealing between the implant and the surrounding gum tissue fails it can result in bacteria entering the implant and causing infection.”