Kaku et al. demonstrate that the efficacy of neutralizing mAbs and convalescent plasma is maintained against SARS-CoV-2 variants B.1.1.7 from the UK and mink cluster 5 but decreases against B.1.351 from South Africa and P.1 from Brazil. Rapid spread of these variants significantly impacts SARS-CoV-2 therapies and vaccine strategies.
Circa 2016 Basically means we can see contaminated water easier.
Detection and quantification of contaminants or pollutants in surface waters is of great importance to ensure safety of drinking water and for the aquatic environment1,2,3,4,5,6. Metaldehyde (CH3CHO)4 is a cyclic tetramer of acetaldehyde and is used extensively around the world as a molluscicide in agriculture for the control of slugs to protect crops. Large amounts of metaldehyde residues (from ‘slug pellets’) become mobilized, especially during periods of rainfall, seeping into reservoirs, rivers and groundwater, from which drinking water is sourced. Although metaldehyde has low toxicity, cases of metaldehyde poisoning and death in both humans and animals have been reported6,7,8. The United States Environmental Protection Agency (EPA) re-registered metaldehyde as a ‘restricted use pesticide’ and required risk-reduction measures to be adopted due to the potential short-term and long-term effects on wildelife9,10. The World Health Organization (WHO) classifies metaldehyde as a “moderately hazardous” pesticide (class II)11. In Europe, the European Commission has adopted a directive that restricts pesticides levels to 0.1 μg/L in drinking water12,13. Water companies and environmental agencies are under increasing pressure to routinely monitor levels of metaldehyde residues in water courses as part of their legal obligation14. As such there is an increasing need to develop effective analytical methods for detecting and quantifying metaldehyde in water samples at the source. In particular in-situ monitoring is required to ensure water management practices are based on empirical, up-to-date information which provides a better understanding of competing factors, risk and requirement.
Rapid analytical methods for in-situ analysis of metaldehyde in water, if available, would provide critical information on water quality for water companies and regulation bodies to manage exposures. Quantitative analysis of metaldehyde has been reported using various ex-situ methods based on solid-phase extraction8,15 followed by gas chromatography (GC) or high performance liquid chromatography (HPLC) with mass spectrometry (MS)7,14,15,16,17,18. However, each of these analytical methods involves extensive sample preparation including extraction, separation, and derivatization, resulting in increased cost and time of analysis. As will be demonstrated in this study, ambient ionization (AI) combined with tandem mass spectrometry (MS/MS) can overcome such limitations19,20,21,22.
AI is a form of ionization that is performed on unmodified samples in open air and the method is capable of providing almost instantaneous data while minimizing sample preparation22,23,24,25,26,27,28,29. Some of the most popular AI techniques include desorption electrospray ionization (DESI)30, extractive electrospray ionization (EESI)31,32,33,34,35,36, desorption atmospheric pressure chemical ionization (DAPCI)37,38,39, and direct analysis in real time (DART)40,41. AI-MS shows promise as an analytical tool for in-situ applications and has been demonstrated in a variety of fields where timely intervention is highly desirable such as: homeland security23, food safety42, pharmaceutical drug development43, and environmental monitoring44. There are several advantages to using in-situ AI methods capable of onsite analysis.
A more contagious subvariant of Detla has been found.
MOSCOW, Oct 21 (Reuters) — Russia has reported “isolated cases” of COVID-19 with a subvariant of the Delta variant that is believed to be even more contagious, the state consumer watchdog’s senior researcher said on Thursday.
The researcher, Kamil Khafizov, said the AY.4.2 subvariant may be around 10% more infectious than the original Delta — which has driven new cases and deaths to a series of record daily highs in Russia — and could ultimately replace it.
However, he said this was likely to be a slow process.
The central principle of superconductivity is that electrons form pairs. But can they also condense into foursomes? Recent findings have suggested they can, and a physicist at KTH Royal Institute of Technology today published the first experimental evidence of this quadrupling effect and the mechanism by which this state of matter occurs.
A team of researchers at UT Southwestern Medical Center’s Touchstone Diabetes Center have successfully used CRISPR gene editing to turn fat cells normally used for storage into energy-burning cells.
“It’s like flipping a switch. We removed the ‘brake’ on the energy burning pathway in fat cells by engineering a mutation that disrupts the interaction between a single pair of proteins,” said study leader Rana Gupta, Ph.D., Associate Professor of Internal Medicine. “Our research demonstrates that releasing this brake in fat cells can potentially help make existing diabetes medications much more effective.”
The research at UT Southwestern, ranked as one of the nation’s top 25 hospitals for diabetes and endocrinology care, is published in Genes and Development and supported by the National Institutes of Health.
Deep North, a Foster City, California-based startup applying computer vision to security camera footage, today announced that it raised $16.7 million in a Series A-1 round. Led by Celesta Capital and Yobi Partners, with participation from Conviction Investment Partners, Deep North plans to use the funds to make hires and expand its services “at scale,” according to CEO Rohan Sanil.
Deep North, previously known as Vmaxx, claims its platform can help brick-and-mortar retailers “embrace digital” and protect against COVID-19 by retrofitting security systems to track purchases and ensure compliance with masking rules. But the company’s system, which relies on algorithms with potential flaws, raises concerns about both privacy and bias.
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Russia has registered the world’s first COVID-19 vaccine for animals, the country’s agricultural regulator said on Wednesday.
Clinical trials of the vaccine — called Carnivac-Cov — started last October and involved dogs, cats, Arctic foxes, minks, foxes and other animals, said Konstantin Savenkov, deputy head of Rosselkhoznadzor, according to a Reuters report.
Ingham County cat tested positive for virus that causes COVID-19. Its owners were confirmed to have COVID-19 about a week before the cat became ill.
The zoo said it has been vaccinating big cats, great apes, red pandas, goats, giraffes, river otters, skunks, bearcats and some domestic dogs and cats.
FDA amended the emergency use authorization (EUA) for the Pfizer-BioNTech COVID-19 Vaccine to allow for the use of a single booster dose, to be administered at least six months after completion of the primary series with the Pfizer-BioNTech COVID-19 Vaccine in certain populations.