Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: biotech/medical – Page 1446

New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged.

Over the past decade, the CRISPR-Cas9 gene editing system has revolutionized genetic engineering, allowing scientists to make targeted changes to organisms’ DNA. While the system could potentially be useful in treating a variety of diseases, CRISPR-Cas9 editing involves cutting DNA strands, leading to permanent changes to the cell’s genetic material.

Now, in a paper published online in Cell on April 9, researchers describe a new gene editing technology called CRISPRoff that allows researchers to control gene expression with high specificity while leaving the sequence of the DNA unchanged. Designed by Whitehead Institute Member Jonathan Weissman, University of California San Francisco assistant professor Luke Gilbert, Weissman lab postdoc James Nuñez and collaborators, the method is stable enough to be inherited through hundreds of cell divisions, and is also fully reversible.

Read more | >

Daily injections of insulin are a hassle for the hundreds of millions of people with diabetes. An oral pill would be much easier to swallow (pun intended), and now researchers from New York University Abu Dhabi have developed a new method for packing insulin into capsules that can survive the trip through the stomach to the bloodstream, and only release their payload when it’s needed.

Diabetes is characterized by inconsistent levels of insulin, a hormone that regulates glucose levels in the blood. Normally the condition is managed with regular subcutaneous injections, but they can be difficult for patients to self-administer, and the unpleasantness may make some people skip doses.

In an ideal world, managing diabetes would be as simple as popping a pill, but unfortunately developing that kind of system has been tricky. Insulin is a fragile molecule that’s quickly broken down in the stomach before it can work its magic. Much of the challenge for scientists then is to find ways to package insulin so it survives long enough to permeate the intestinal wall to get into the bloodstream.

Read more | >

The gene editing system CRISPR-Cas9 makes breaks in DNA strands that are repaired by cells—a process that can be hard to control, resulting in unwanted genetic changes. Researchers at the Massachusetts Institute of Technology and the University of California, San Francisco (UCSF) designed an alternative technology that changes gene expression without damaging DNA, and they believe it could be useful for both research and drug development.

The researchers used their system, dubbed CRISPRoff and CRISPRon, to induce pluripotent stem cells to transform into neurons. They also used it to silence the gene that makes the protein Tau, which has been implicated in Alzheimer’s disease. They described their research in the journal Cell.

The MIT and UCSF researchers started by creating a machine made of a protein and small RNAs that guided it to specific spots on strands of DNA. The machine adds “methyl groups” to genes to silence their expression. The technology can also reverse the process, turning the genes back on by removing the methyl groups.

Read more | >

Watch a Soyuz MS-18 spacecraft lift off on a two-orbit, three-hour journey to the International Space Station! NASA astronaut Mark Vande Hei and cosmonauts Oleg Novitskiy and Pyotr Dubrov of Roscosmos are scheduled to launch at 3:42 a.m. EDT, Friday, April 9, from the Baikonur Cosmodrome in Kazakhstan.

The trio will be part of Expeditions 64 and 65 on the station, where they’ll continue work on hundreds of experiments in biology, biotechnology, physical science, and Earth science. This will be Vande Hei’s second spaceflight, Novitskiy’s third, and Dubrov’s first.

Read more | >

Summary: A new blood test can distinguish the severity of a person’s depression and their risk for developing severe depression at a later point. The test can also determine if a person is at risk for developing bipolar disorder. Researchers say the blood test can also assist in tailoring individual options for therapeutic interventions.

Source: Indiana University.

Worldwide, 1 in 4 people will suffer from a depressive episode in their lifetime.

Read more | >

Summary: A newly developed reparative hydrogel, which researchers are dubbing “brain glue”, protects against loss of brain tissue following a TBI and can aid in functional neural repair.

Source: University of Georgia.

At a cost of $38 billion a year, an estimated 5.3 million people are living with a permanent disability related to traumatic brain injury in the United States today, according to the Centers for Disease Control and Prevention. The physical, mental and financial toll of a TBI can be enormous, but new research from the University of Georgia provides promise.

Read more | >

A team of researchers at Shanghai Jiao Tong University, has found that the human hand can be used as a powerless infrared radiation (IR) source in multiple kinds of applications. In their paper published in Proceedings of the National Academy of Sciences, the group notes that the human hand naturally emits IR and they demonstrate that the radiation can be captured and used.

The emits light in the invisible IR range, including the hands. This source of radiation, the researchers noted, could potentially be captured and used in applications ranging from signal generation to encryption systems. They further noted that because the hand has multiple fingers, the IR that it emits could be considered to be multiplexed.

IR is a form of —its wavelengths are longer than those of , which is why humans cannot see them. Prior research has shown that the human body emits such radiation due to body heat. Electromagnetic radiation carries with it radiant energy, and its behavior is classified as both a quantum particle and a wave. Prior research has also shown that electromagnetic radiation can be used in a variety of applications, including microwaves, radios and medical imaging devices. And , in particular, enables night vision goggles, spectroscopy devices and used to treat burn victims. In this new effort, the researchers have found that the very small amount of IR emitted by the human hand is sufficient to use in various devices.

Read more | >

Find out how endocrine disrupting chemicals, like BPA, can render most men sterile by 2045. Learn about chemicals in our food that disrupt our immune system, about cancer causing chemical in hand sanitizers. See what these have to do with sperm counts falling. How do they affect wildlife, and food production. See what you can do about it!

Green Gregs has teamed up with True Leaf Market to bring you a great selection of seed for your spring planting. Check it out: http://www.pntrac.com/t/TUJGRklGSkJGTU1IS0hCRkpIRk1K

See the Special Deals at My Patriot Supply: www.PrepWithGreg.com.

Support freedom: FreedomRestorationFoundation.org.

Continue reading “Men to Be Sterile by 2045 — Escape Chemicals to Thrive” | >