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Apr 22, 2022

Lab grown, self-sustainable muscle cells repair injury and disease, mouse study shows

Posted by in categories: biotech/medical, genetics

In proof-of-concept experiments, Johns Hopkins Medicine scientists say they have successfully cultivated human muscle stem cells capable of renewing themselves and repairing muscle tissue damage in mice, potentially advancing efforts to treat muscle injuries and muscle-wasting disorders in people.

A report on the experiments was published April 7 in Cell Stem Cell.

To make the self-renewing stem cells, the scientists began with laboratory-grown human skin cells that were genetically reprogrammed to a more primitive state in which the cells have the potential to become almost any type of cell in the body. At this point, the cells are known as induced pluripotent stem (IPS) cells, and they are mixed with a solution of standard cell growth factors and nutrients that nudge them to differentiate into specific cell types.

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