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Repetitive Transcranial Magnetic Stimulation (rTMS)

Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive treatment approved by the U.S. Food and Drug Administration for the treatment of clinical depression. The treatment is also being studied as a potential therapy for Alzheimer’s disease.

How rTMS works

Alzheimer’s disease is the most common cause of dementia, affecting millions of mostly elderly people around the world. In these people, the synaptic activity (connections between nerve cells) collapses and brain networks gradually falter, resulting in a decline in memory and the ability to think and learn.

Musk approaches brain chip startup Synchron about deal amid Neuralink delays

Musk seems frustrated with the delays in Neuralink’s progress.

Elon Musk, the world’s richest person has reached out to a competitor Synchron Inc. about a potential investment after his own biotech company Neuralink has lagged in developing an implantable brain chip, Reuters reported.

Launched in 2016, Neuralink was co-founded by Musk to develop implantable brain-chip interfaces to connect humans and computers. Like his ambitious projections about his electric vehicles, Musk had ambitiously claimed in 2019 that Neuralink was aiming for its product to receive regulatory approval by the end of 2020.

Later in 2021, when the company had not even begun human trials, Musk claimed at a Wall Street Journal conference that he expected them to begin by 2022, but the company has failed to get the regulatory nod to do so, even at the time of writing this. Contrastingly, a startup, Synchron, received the necessary approvals last year.

Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation

This method could be helpful for elderly people.

Our brain has both short-term and long-term memory. While short-term memory helps us with things like remembering the bus number, long-term memory processes information for a long time. However, as we age, our memory does not work as well as it used to.

Electrical brain stimulation for 20 minutes on four consecutive days can improve two different types of memory in individuals 65 years and older for at least one month, a study published in the journal Nature Neuroscience reveals.

According to the study, this method could be beneficial for elderly people to maintain their errands very easily.


Reinhart et al. show that repetitive transcranial alternating current stimulation (tACS) of unique combinations of rhythmic frequency and stimulation locations produces selective and long-lasting improvements in verbal working memory and long-term memory in older adults.

Pawpaws are America’s hidden edible treasure. Here’s how to pick them

Pawpaw varieties are assessed on their flavor, yield, fruit size, texture, and disease resistance, Crabtree says. She adds that the “best varieties” would be high yield trees that produce a pawpaw with “firmness and/or creaminess that’s not watery, mushy, or gritty” as well as a lower percentage of seeds.

Hunting for pawpaw

Native to 26 states, pawpaw can be found along the East Coast between Ontario, Canada, and northern Florida west to Kentucky, Ohio, Michigan, Nebraska, Kansas, and even Texas.

Chaos synchronization between linearly coupled chaotic systems

Chaos, as a very interesting nonlinear phenomenon, has been intensively studied in the last three decades [10], [13]. It is found to be useful or has great potential in many disciplines such as in collapse prevention of power systems, biomedical engineering applications to the human brain and heart, thorough liquid mixing with low power consumption, secret communication technology, to name just a few [10], [13], [24].

Over the last decade, many new types of synchronization have appeared: chaotic synchronization [3], [4], lag synchronization [9], adaptive synchronization [2], phase synchronization [6], and generalized synchronization [9], to mention only a few. Since the discovery of chaos synchronization [3], there has been tremendous interest in studying the synchronization of chaotic systems [10]. Recently, synchronization of coupled chaotic systems has received considerable attention [1], [2], [5], [7]. Especially, a typical study of synchronization is the coupled identical chaotic systems [1], [6].

In 1963, Lorenz found the first classical chaotic attractor [12]. In 1999, Chen found another similar but topologically not equivalent chaotic attractor [11], [21], [22], as the dual of the Lorenz system, in a sense defined by Vanĕc̆ek and C̆elikovský [23]: The Lorenz system satisfies the condition a12 a21 0 while Chen system satisfies a12 a21 0. Very recently, Lü et al. produced a new chaotic system [14], [15], which satisfies the condition a12 a21 =0, thereby bridging the gap between the Lorenz and Chen attractors [15], [16], [17].

In a week, we can tell if something slows aging

The early-stage development of many age-targeting compounds often involves studies of their effects on the lifespan of the transparent nematode (worm) model Caenorhabditis elegans. A highly manual process, this exercise is time-consuming and only produces data on one endpoint – lifespan.

Durham University associate professors David Weinkove and Chris Saunter invented a technology that automates measurements of movement in many large populations of worms simultaneously. Crucially, this technology goes beyond measuring lifespan, also capturing information about how worms’ health declines as they age – their healthspan.

Longevity. Technology: Together, Weinkove and Saunter have co-founded a spinout company called Magnitude Biosciences, leveraging their innovative platform to test drugs and other interventions for their capacity to prolong healthspan. We caught up with Weinkove to learn more about the background to the company and where it goes from here.

Remedium Bio closes successful $2.3m expanded seed raise

Remedium Bio has announced that it has closed more than $2.3m in its expanded seed round financing. Funding from the raise is being used to study Remedium’s lead product, a single-injection gene therapy potentially capable of reversing cartilage loss; this research is being conducted in collaboration with scientists from Tufts University School of Medicine who are engaged in researching rheumatic disorders.

The financing was led by Sherwood Ventures and included participation from, LongevityTech. Fund, Primo Medical Group, Angel Star Ventures, Apis Health Angels, MicroVentures, and Guindy Alumni Angels.

Longevity. Technology: Remedium’s pipeline includes therapeutic indications in osteoarthritis, diabetes, stroke and other large unmet clinical needs.

Biotech firm wants to grow human embryos for organ harvesting

A biotech firm wants to create “synthetic” human embryos that would be used to harvest organs in order to facilitate transplants and treat conditions such as infertility, genetic disease, and aging, according to researchers.

The Israel-based company, Renewal Bio, claimed that it successfully used advanced stem cell technology and artificial wombs in order to grow mouse embryos which continued to develop for several days.

New AI-enabled, optical fiber sensor device could help monitor brain injury

A new AI-enabled, optical fiber sensor device developed at Imperial College London can measure key biomarkers of traumatic brain injury simultaneously.

The “promising” results from tests on animal tissues suggest it could help clinicians to better monitor both and patients’ response to treatment than is currently possible, which indicate the high potential for future diagnostic trials in humans.

People who experience a serious blow to the head, such as during road traffic accidents, can suffer (TBI)—a leading cause of death and disability worldwide that can result in long-term difficulties with memory, concentration and solving problems.

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