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Hematopoietic stem cells—the precursors to blood cells—have been notoriously difficult to grow in a dish, a critical tool in basic research. Scientists at University of California San Diego School of Medicine have identified the underlying issue and developed a method to keep cultured cells healthy. These findings, they say, are positive news for patients seeking stem cell transplants—and may hint at a new way to ward off aging.

The findings will be published in the August 12 2021 online issue of Cell Stem Cell.

In transplants, hematopoietic stem are infused intravenously to reestablish blood production in patients whose bone marrow or is damaged. The procedure is used to treat diseases such as leukemia, lymphoma, aplastic anemia and immune deficiency disorders. However, are not always available for patients who need them.

Steroid-based inhalers deliver life-saving medication for millions of asthma sufferers, providing relief and the ability to simply breathe. Unfortunately, inhalers do not work for all patients, and with rates on the rise for a disease that leads to hundreds of thousands of deaths world-wide each year, new asthma treatments and strategies are needed.

A team of UConn researchers—including Assistant Professor of Chemistry in the College of Liberal Arts and Sciences Jessica Rouge and Associate Professor of Pathobiology in the College of Agriculture, Health, and Natural Resources Steven Szczepanek—are collaborating to develop novel therapeutics using gene-silencing nanocapsules in a bid to help patients who aren’t benefiting from existing treatments. Their research was published in ACS Nano.

“When treating asthma, many people think of small molecule anti-inflammatory medications as the way to go, but there are plenty of patients who have asthma who do not respond to corticosteroids,” says Rouge. “There’s an unmet need for creating different therapeutics that can suppress asthma for this group of people.”

A 21st Century Mystery School — “Creating New Paradigms In Wellness And Wisdom Never Seen Before, And Never More Needed Than Now” — Dr. Dennis McKenna, Founder, McKenna Academy of Natural Philosophy.


Dr. Dennis McKenna is an American ethnopharmacologist, research pharmacognosist, lecturer, author, and Founder of the McKenna Academy of Natural Philosophy (www.mckenna.academy).

Dr. McKenna is a founding board member and the director of ethnopharmacology at the Heffter Research Institute, a non-profit organization concerned with the investigation of the potential therapeutic uses of psychedelic medicines. He also serves on the Advisory Board of the American Botanical Council; as Founder and Executive Director for the Institute for Natural Products Research; as an Independent Research Consultant to the Phytomedicine and Nutraceutical Industry; was formerly on the Editorial Board of Phytomedicine, International Journal of Phytotherapy and Phytopharmacology; and is an adjunct professor in the Center for Spirituality and Healing at the University of Minnesota.

In other words, the mix of positives and negatives puts this potent new suite of technologies on a knife-edge. Do we have confidence that a handful of companies that have already lost public trust can take AI in the right direction? We should have ample reason for worry considering the business models driving their motivations. To advertising-driven companies like Google and Facebook, it’s clearly beneficial to elevate content that travels faster and draws more attention—and misinformation usually does —while micro-targeting that content by harvesting user data. Consumer product companies, such as Apple, will be motivated to prioritize AI applications that help differentiate and sell their most profitable products—hardly a way to maximize the beneficial impact of AI.

Yet another challenge is the prioritization of innovation resources. The shift online during the pandemic has led to outsized profits for these companies, and concentrated even more power in their hands. They can be expected to try to maintain that momentum by prioritizing those AI investments that are most aligned with their narrow commercial objectives while ignoring the myriad other possibilities. In addition, Big Tech operates in markets with economies of scale, so there is a tendency towards big bets that can waste tremendous resources. Who remembers IBM’s Watson initiative? It aspired to become the universal, go-to digital decision tool, especially in healthcare—and failed to live up to the hype, as did the trendy driverless car initiatives of Amazon and Google parent Alphabet. While failures, false starts, and pivots are a natural part of innovation, expensive big failures driven by a few enormously wealthy companies divert resources away from more diversified investments across a range of socially productive applications.

Despite AI’s growing importance, U.S. policy on how to manage the technology is fragmented and lacks a unified vision. It also appears to be an afterthought, with lawmakers more focused on Big Tech’s anti-competitive behavior in its main markets—from search to social media to app stores. This is a missed opportunity, because AI has the potential for much deeper societal impacts than search, social media, and apps.

Circa 2019


An add-on device for smartphones could replace blood glucose meters for measuring blood sugar. Blood sugar measurements are essential for diabetes patients who need to know their blood glucose concentration in order to regulate it with insulin. Failure to do so might result in complications from the disease. The device, designed by researchers in Taiwan, achieved 100% accuracy in a test with 20 blood samples from diabetes patients (J. Biomed. Opt. 10.1117/1.JBO.24.2.027002).

The researchers designed a compact device containing no electrical components that can be used in combination with a smartphone. The light from the smartphone’s display reflects onto the blood glucose test site (BGTS) inside the device, which contains a colorimetric test strip. The user adds a blood drop to the test strip, which is then assessed for a colour change using the phone’s front camera.

In this study, the blood drop was obtained from a vein, but the device is designed to work on drops extracted from the patient’s finger using a disposable lance that is then inserted into the device. The observed colour is split into its red, green and blue components. The researchers used the green component as an indicator of blood glucose concentration, as it could reliably distinguish the widest concentration range out of the three components.

Circa 2018


A major challenge in treating type 1 diabetes is figuring out how to overcome the destruction of insulin-producing beta cells. The body mistakenly targets and destroys these cells leaving the body unable to manage blood sugar levels on its own. Individuals with this disease must be vigilant about checking their blood sugar and administering insulin as needed, which can be an exhausting task.

Current treatment options include injection of insulin, use of continuous glucose monitors and insulin pumps, stem cell therapies and implants, partial transplants, and other strategies. These treatments vary in effectiveness from person to person as well as how long they last. In addition, some require patients to continue taking anti-rejection drugs which can be hard on the body.

However, a new treatment may offer longer lasting, more effective results in the battle against type 1 diabetes. A recent study found that by using gene therapy targeting two specific genes, insulin-producing cells may be able to be recreated in the body using existing alpha cells. A healthy pancreas contains both alpha and beta cells. In those with type 1 diabetes, insulin-producing beta cells are destroyed. But when mice were injected with gene therapy to reprogram some alpha cells to take over the function of these beta cells, they were once again able to produce insulin and manage blood sugar.

Pear-shaped people, whose weight is generally distributed more evenly, rather than “apple shaped” individuals with fat clustered around their middle and often around internal organs like the liver in the abdominal cavity, are considered less at risk for cardiometabolic problems like heart disease and diabetes, as well as cognitive decline, says Stranahan, neuroscientist at the Medical College of Georgia at Augusta University.


Summary: Adipocytes, or beige fat cells, are indispensable to the anti-inflammatory and neuroprotective effects of subcutaneous fat, researchers say.

Source: Medical College of Georgia at Augusta University

Beige is considered a calming paint color, and scientists have new evidence that beige fat has a similar impact on the brain, bringing down the inflammation associated with the more common white fat and providing protection from dementia.

When the resulting paste is applied to a wet surface such as blood-covered tissue, the oil repels the blood and other substances that may be present, allowing the adhesive microparticles to crosslink and form a tight seal over the wound. Within 15 to 30 seconds of applying the glue, with gentle pressure applied, the glue sets and bleeding stops, the researchers showed in tests in rats.


A new adhesive that mimics the sticky substance barnacles use to cling to rocks may offer a better way to treat traumatic injuries.

Inspired by the sticky substance that barnacles use to cling to rocks, MIT

MIT is an acronym for the Massachusetts Institute of Technology. It is a prestigious private research university in Cambridge, Massachusetts that was founded in 1861. It is organized into five Schools: architecture and planning; engineering; humanities, arts, and social sciences; management; and science. MIT’s impact includes many scientific breakthroughs and technological advances.