P.E.I. will be making a vaccine that prevents shingles free for seniors next year.
The two dose Shingrix vaccine will be available for Islanders who are 65 and older beginning in January.
Erin MacKenzie, executive director of the P.E.I. Pharmacists Association, said one dose of the vaccine usually costs around $180.
Most human diseases can be traced to malfunctioning parts of a cell—a tumor is able to grow because a gene wasn’t accurately translated into a particular protein or a metabolic disease arises because mitochondria aren’t firing properly, for example. But to understand what parts of a cell can go wrong in a disease, scientists first need to have a complete list of parts.
By combining microscopy, biochemistry techniques and artificial intelligence, researchers at University of California San Diego School of Medicine and collaborators have taken what they think may turn out to be a significant leap forward in the understanding of human cells.
The technique, known as Multi-Scale Integrated Cell (MuSIC), is described November 24, 2021 in Nature.
Research led by UT Southwestern and the University of Washington could lead to a wealth of drug targets.
UT Southwestern and University of Washington researchers led an international team that used artificial intelligence (AI) and evolutionary analysis to produce 3D models of eukaryotic protein interactions. The study, published in Science, identified more than 100 probable protein complexes for the first time and provided structural models for more than 700 previously uncharacterized ones. Insights into the ways pairs or groups of proteins fit together to carry out cellular processes could lead to a wealth of new drug targets.
“Our results represent a significant advance in the new era in structural biology in which computation plays a fundamental role,” said Qian Cong, Ph.D., Assistant Professor in the Eugene McDermott Center for Human Growth and Development with a secondary appointment in Biophysics.
Natural selection, the evolutionary process that guides which traits become more common in a population, has been acting on us for the past 3,000 years, right up to the modern day, new research suggests.
And it seems to be acting in surprising ways on complex traits encoded by multiple genes, such as those tied to intelligence, mental illness and even cancer.
The SARS-CoV-2 gene set remains unresolved, hindering dissection of COVID-19 biology. Comparing 44 Sarbecovirus genomes provides a high-confidence protein-coding gene set. The study characterizes protein-level and nucleotide-level evolutionary constraints, and prioritizes functional mutations from the ongoing COVID-19 pandemic.
𝐌𝐀𝐆𝐈𝐂 𝐌𝐔𝐒𝐇𝐑𝐎𝐎𝐌 𝐒𝐓𝐔𝐃𝐘 𝐒𝐔𝐆𝐆𝐄𝐒𝐓𝐒 𝐏𝐒𝐈𝐋𝐎𝐂𝐘𝐁𝐈𝐍 𝐌𝐀𝐘 𝐑𝐄𝐕𝐄𝐑𝐒𝐄 𝐀𝐋𝐂𝐎𝐇𝐎𝐋-𝐈𝐍𝐃𝐔𝐂𝐄𝐃 𝐁𝐑𝐀𝐈𝐍 𝐃𝐀𝐌𝐀𝐆𝐄
𝘼𝙁𝙏𝙀𝙍 𝙃𝘼𝙇𝙁 𝘼 𝘾𝙀𝙉𝙏𝙐𝙍𝙔 𝙤𝙛 𝙗𝙡𝙤𝙘𝙠𝙨 𝙩𝙤 𝙧𝙚𝙨𝙚𝙖𝙧𝙘𝙝 𝙤𝙣 𝙥𝙨𝙮𝙘𝙝𝙚𝙙𝙚𝙡𝙞𝙘𝙨’ 𝙥𝙤𝙩𝙚𝙣𝙩𝙞𝙖𝙡 𝙛𝙤𝙧 𝙩𝙧𝙚𝙖… See more.
The psychedelic drug psilocybin can restore alcohol-induced damage to the brain’s glutamate receptors — that’s the finding of a new study published in ‘Science Advances.’
😳! Circa 2018
Some animals live fast and die young. That means they need to grow up fast, too. This week, researchers crowned a new record holder for quick growth: Susan Milius at Science News reports that the turquoise killifish, Nothobranchius furzeri, found in Mozambique, can reach maturity in just 14 days, the fastest of any known vertebrate animal.
That rapid maturation is an adaptation to the killifish’s habitat, according to the study published this week in the journal Current Biology. The fish spend most of their lives as tiny embryos that have been deposited in sediment in small depressions across the savannah. When rain fills the ephemeral pools, the embryos mature rapidly reaching sexual maturity and depositing their own embryos before the pool once again dries up. Not only do they make babies quickly, they bulk up fast, too—typically growing from about 5 millimeters to 54 millimeters in their lifespan.
Researchers have been aware of the turquoise killifish’s super-fast maturation for a while. In fact, the fish is used as a model animal in aging studies because of this trait. In the lab, where the fish live a relatively leisurely lifestyle, the average rate of maturation is 18 days.
Two new methods make it possible to delete long sections of the genome, expanding the capabilities of the gene editor CRISPR. The techniques could lead to therapies that excise large insertions or duplications tied to autism, such as the DNA repeats that underlie fragile X syndrome.
To remove a segment of DNA, CRISPR systems typically use an enzyme called Cas9 to snip double-stranded DNA at two target sites. The cell’s own repair machinery can then join the cut ends, omitting the intervening sequence. But this process is error prone and can insert or delete unintended segments of DNA, called ‘indels,’ or rearrange large sections of the genome. Snipping double-stranded DNA can also cause cell death.
A different CRISPR-based system called ‘prime editing’ can make DNA repair more precise. In one version of the technique, a protein complex called a prime editor cuts only one strand of DNA at one of the two sites and the opposite strand at the other site. The prime editor adds a sequence to one of the cut strands to guide the repair.
The most promising application in biomedicine is in computational chemistry, where researchers have long exploited a quantum approach. But the Fraunhofer Society hopes to spark interest among a wider community of life scientists, such as cancer researchers, whose research questions are not intrinsically quantum in nature.
“It’s uncharted territory,” says oncologist Niels Halama of the DKFZ, Germany’s national cancer center in Heidelberg. Working with a team of physicists and computer scientists, Halama is planning to develop and test algorithms that might help stratify cancer patients, and select small subgroups for specific therapies from heterogeneous data sets.
This is important for precision medicine, he says, but classic computing has insufficient power to find very small groups in the large and complex data sets that oncology, for example, generates. The time needed to complete such a task may stretch out over many weeks—too long to be of use in a clinical setting, and also too expensive. Moreover, the steady improvements in the performance of classic computers are slowing, thanks in large part to fundamental limits on chip miniaturization.
Circa 2012 o.o
New DNA tests suggest the owner of a British fertility clinic may have fathered as many as 600 children, while keeping his donations a secret. And in an even stranger twist, one of his newly discovered offspring says the man’s belief in eugenics may have been behind the decision.
The Telegraph reports that Bertold Wiesner and his wife operated a fertility clinic in the 1940s and were responsible for helping more than 1,500 families conceive. Two of the children conceived through clinic donations, Barry Stevens and David Gollancz, took part in DNA testing that revealed both were conceived using Wiesner’s sperm.
“Using standard figures for the number of live births which result, including allowances for twins and miscarriages, I estimate that he is responsible for between 300 and 600 children,” Gollancz told the paper.