A team of researchers from Russia, the Czech Republic and Israel has found that the reason some blind mole rats live longer than other small creatures is because they have short immune memory. In their paper published in the journal Nature Aging, the group describes their study of the adaptive immune system of long-lived blind mole rats.
Stimuli-responsive control of drug activation can mitigate issues caused by poor drug selectivity. Now, it has been shown that mechanical force—induced by ultrasound—can be used to activate drugs in three different systems. This approach has enabled the activation of antibiotics or a cytotoxic anticancer agent from synthetic polymers, polyaptamers and nanoparticle assemblies.
CRISPR/Cas9 treatment allowed mice to live 25% longer and be physically stronger. Biologists see these results being relatively easy to reproduce on humans in a clinical setting.
Cell-Intrinsic Learning And Memory Storage Dynamics — Dr. David Glanzman Ph.D., Professor, in the Department Integrative Biology and Physiology, at UCLA College of the Life Sciences.
Dr. David Glanzman is Professor, in the Department Integrative Biology and Physiology, at UCLA College of the Life Sciences, Professor in the Department of Neurobiology in the David Geffen School of Medicine, and Member, Brain Research Institute.
If an opinion poll were taken for the most popular component of mammalian cells, the result probably would be a 50–50 split: Half of respondents would likely vote hands down for the nucleus and the other half for the mitochondria—a decision that in no way diminishes or casts aspersions on the other hardworking constituents of cells.
In this special episode of Hello World, best-selling author and Bloomberg Businessweek journalist Ashlee Vance goes on a RV road trip through California in the midst of a pandemic and sweeping forest fires. Along the way, he hangs out with a Tesla co-founder who wants to recycle all the world’s batteries, some robotic farmers, a test pilot who almost lost his life and desert space-geeks building a lunar lander.
#HelloWorld #BloombergBusinessweek #California.
Continue reading “Pioneers in the Desert: A Tech-Infused Road Trip” »
A team of Australian researchers believe they have taken a significant step towards unlocking the regenerative power of the stem cells in our bodies.
Despite great advances in the field of intensive care, when patients survive a severe.
Brain injury but remain in a chronic Vegetative State (VS) or Minimally Conscious.
State (MCS) (i.e., a disorder of consciousness; DOC), little can be done to promote.
Continue reading “Ultrasonic thalamic stimulation in chronic disorders of consciousness” »
Circulating branched-chain amino acids (BCAAs) are elevated in obesity and diabetes, and recent studies support a causal role for BCAAs in insulin resistance and defective glycemic control. The physiological mechanisms underlying BCAA regulation are poorly understood. Here we show that insulin signaling in the mediobasal hypothalamus (MBH) of rats is mandatory for lowering plasma BCAAs, most probably by inducing hepatic BCAA catabolism. Insulin receptor deletion only in agouti-related protein (AgRP)–expressing neurons (AgRP neurons) in the MBH impaired hepatic BCAA breakdown and suppression of plasma BCAAs during hyperinsulinemic clamps in mice. In support of this, chemogenetic stimulation of AgRP neurons in the absence of food significantly raised plasma BCAAs and impaired hepatic BCAA degradation.
2 things I like here. 1. Aubrey says not only does he think the first person to live to 1000 may be alive today but that they are already middle aged(Like me!). 2. In 15 years we might give a 70 year old treatment that will not make them 20 again, but perhaps it will make them 40. then by the time they hit 70 again the treatments available will be even better.
Dr. Aubrey de Grey is a biomedical gerontologist based in Mountain View, California, USA, and is the Chief Science Officer of SENS Research Foundation, a California-based 501©(3) biomedical research charity that performs and funds laboratory research dedicated to combating aging. In addition, he is Editor-in-Chief of Rejuvenation Research, the world’s highest-impact peer-reviewed journal focused on intervention in aging. He received his BA in computer science and Ph.D. in biology from the University of Cambridge. His research interests encompass the characterization of all the types of self-inflicted cellular and molecular damage that constitute mammalian aging and the design of interventions to repair and/or obviate that damage. Dr. de Grey is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the editorial and scientific advisory boards of numerous journals and organizations. He is a highly sought-after speaker who gives 40–50 invited talks per year at scientific conferences, universities, companies in areas ranging from pharma to life insurance, and to the public. Topics Discussed: Brief overview of SENS
- Why try to end aging?
- How soon do you think we will end aging?
- What role does rejuvenation biotech play in the COVID-19 pandemic? How would regenerative medicine help us better cope with the pandemic?
- How are you implementing the techniques you research in your own life?
- Which breakthrough are you most proud of?Aubrey’s Links: LinkedIn: https://www.linkedin.com/in/aubrey-de-grey-24260b/
Personal Website: https://www.sens.org/
Company Website: https://www.mfoundation.org/
Twitter: https://twitter.com/aubreydegreyListen to the audio version at: https://www.buzzsprout.com/765170/7722976-dr-aubrey-de-grey-…e-agingYou can listen to the audio and read the transcript here: https://podcast.boomerliving.tv/dr-aubrey-de-grey-what-cause…-aging/You can listen to many other audio podcasts on our website and Apple Podcasts: https://podcast.boomerliving.tv/
https://podcasts.apple.com/us/podcast/boomer-living-senior-l…1455929808
