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Category: biotech/medical – Page 1258

Scientists have discovered a way to stop the COVID-19 virus from replicating in infected human cells, marking major progress towards a definitive treatment for the deadly illness and accentuating the potential of genetic engineering to cure viral diseases.

The study explores the use of CRISPR, a genome editing tool, and builds on research that started at Australia’s Peter MacCallum Cancer Center in 2019, when Dr. Mohamed Fareh and Prof. Joe Trapani showed that CRISPR could be used to eliminate abnormal RNAs that drive children’s cancers.

At the beginning of the pandemic, and in collaboration with Director Prof. Sharon Lewin and Dr. Wei Zhao from the Doherty Institute, the scientists reprogrammed the same CRISPR tool to suppress replication of the RNA virus SARS-CoV-2 — and importantly, its “variants of concern” — in a test tube model. SARS-CoV-2, which is short for Severe Acute Respiratory Syndrome Coronavirus 2, is the virus that causes COVID-19.

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Researchers have imaged a major component in conjugation—the process bacteria use to share DNA with each other.

During conjugation, bacteria can exchange genetic information in the form of special pieces of DNA. These include genes that help them resist attacks from common antimicrobial drugs, making many illnesses caused by these bacteria resistant to treatment.

Better understanding conjugation could therefore allow scientists to find ways to stop the process and reduce the spread of antimicrobial resistance.

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Health official are reportedly calling for steps to be taken to keep a potentially worrying new variant of the coronavirus out of the country.

Scientists in South Africa revealed Thursday that they had detected a new COVID-19 variant with “a very high number of mutations,” blamed for an “exponential” surge in infections there.

The number of daily infections in Africa’s hardest-hit country has increased tenfold since the start of the month.

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ROME, July 2 (Reuters) — A United Nations-backed scientific research centre has teamed up with an Italian tech firm to explore whether laser light can be used to kill coronavirus particles suspended in the air and help keep indoor spaces safe.

The joint effort between the International Centre for Genetic Engineering and Biotechnology (ICGEB) of Trieste, a city in the north of Italy, and the nearby Eltech K-Laser company, was launched last year as COVID-19 was battering the country.

They created a device that forces air through a sterilization chamber which contains a laser beam filter that pulverizes viruses and bacteria.

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I am a huge fan of reading. So much so that I’m beginning to think it’s having a negative impact on my social life, but we’ll save that for another time… The point is that I read a LOT. And for the past seven years, I’ve been stuck on one genre: Science Fiction. From space operas and apocalyptic disasters, to robot revolts and galaxy-spanning quests — I’m down for it all.

The best sci fi authors can n o t only see how innovation might progress, but how humanity might evolve as a result. For a genre so heavily focused on science and technology, it’s surprisingly human.

So I get really excited when I see a headline like Meet Altos Labs, Silicon Valley’s Latest Wild Bet on Living Forever. It makes me feel like I’m living in the future. The rate of scientific advancement over the past 50 years has been increasingly mind boggling and it’s impossible to keep up with all the discoveries. First CRISPR, then private space travel, now immortality? It’s insane. Completely terrifying. And I love it.

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COVID-19 facemasks & marine plastic pollution.

Our oceans will be flooded with an estimated 1.56 billion face masks in 2020 says a report released today by Hong-Kong-based marine conservation organization OceansAsia. This will result in an additional 4,680 to 6,240 metric tonnes of marine plastic pollution, says the report, entitled “Masks on the Beach: The Impact of COVID-19 on Marine Plastic Pollution.” These masks will take as long as 450 years to break down, slowly turning into micro plastics while negatively impacting marine wildlife and ecosystems.

The report used a global production estimate of 52 billion masks being manufactured in 2020, a conservative loss rate of 3%, and the average weight of 3 to 4 grams for a single-use polypropylene surgical face mask to arrive at the estimate.

“The 1.56 billion face masks that will likely enter our oceans in 2020 are just the tip of the iceberg,” says Dr. Teale Phelps Bondaroff, Director of Research for OceansAsia, and lead author of the report. “The 4,680 to 6,240 metric tonnes of face masks are just a small fraction of the estimated 8 to 12 million metric tonnes of plastic that enter our oceans each year.”

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Scientists in South Africa are warning of a new strain of COVID-19. The variant — which is yet to be named — appears to have a high number of mutations. That is of concern, because there’s a possibility it could be able to evade our immune response and be even more transmissible. South Africa has called for an emergency meeting of the World Health Organization to discuss this new variant.

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Scientists have discovered a new route to produce complex antibiotics exploiting gene editing to re-program pathways to future medicines urgently required to combat antimicrobial resistance, treat neglected diseases and tackle future pandemics.

Researchers from The University of Manchester have discovered a new way of manipulating key assembly line enzymes in bacteria which could pave the way for a new generation of antibiotic treatments.

New research published today in Nature Communications, describes how CRISPR-Cas9 gene editing can be used to create new nonribosomal peptide synthetase (NRPS) enzymes that deliver clinically important antibiotics. NRPS enzymes are prolific producers of natural antibiotics such as penicillin. However, up until now, manipulating these complex enzymes to produce new and more effective antibiotics has been a major challenge.

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A cell stores all of its genetic material in its nucleus, in the form of chromosomes, but that’s not all that’s tucked away in there. The nucleus is also home to small bodies called nucleoli — clusters of proteins and RNA that help build ribosomes.

Using computer simulations, MIT chemists have now discovered how these bodies interact with chromosomes in the nucleus, and how those interactions help the nucleoli exist as stable droplets within the nucleus.

Their findings also suggest that chromatin-nuclear body interactions lead the genome to take on a gel-like structure, which helps to promote stable interactions between the genome and transcription machineries. These interactions help control gene expression.

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