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Category: biotech/medical – Page 1,260

One of the most upsetting aspects of age-related memory decline is not being able to remember the face that accompanies the name of a person you just talked with hours earlier. While researchers don’t understand why this dysfunction occurs, a new study conducted at University of Maryland School of Medicine (UMSOM) has provided some important new clues. The study was published on September 8 in Aging Cell.

Using aging , researchers have identified a new mechanism in neurons that causes memories associated with these social interactions to decline with age. In addition, they were able to reverse this in the lab.

The researchers report that their findings identified a specific target in the brain that may one day be used to develop therapies that could prevent or reverse loss due to typical aging. Aging memory problems are distinct from those caused by diseases like Alzheimer’s or dementia. At this time, there are no medications that can prevent or reverse cognitive decline due to typical aging.

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Magnetorotational instability—a process that might explain the dynamics of astrophysical accretion disks—has finally been observed in the laboratory.

What do black holes, forming stars, and a tank of liquid metal in Princeton, New Jersey, have in common? The first two might and the third one definitely does play host to an important process in magnetized-fluid dynamics called magnetorotational instability (MRI). MRI has been well studied theoretically and computationally, and related processes have been seen experimentally [1]. But until now, there has not been an unambiguous laboratory confirmation of its existence. Yin Wang and his colleagues at Princeton University have demonstrated MRI in an ingenious liquid-metal experiment—the culmination of more than 20 years of work [2].

The team’s discovery is significant because MRI has long been suspected of being at the heart of accretion [3]. Accretion, in which material spirals inward in a flattened disk around a black hole or a young star, is a major source of the light coming from those objects. For accretion to occur, the material in the disk must lose its angular momentum. However, angular momentum is conserved: much like the trash we generate in our daily lives, it does not cease to exist when it is not wanted. Instead, angular momentum must be passed from the inner parts of the disk to the outer parts. What drives this angular-momentum transport has long been a mystery.

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In 1998 I was exposed to the term “disruptive innovation” for the first time. I read a wonderful book, “The Innovator’s Dilemma” by Clayton Christensen, where I learned the difference between incremental innovation and disruptive innovation. He analyzed the hard drive industry and showed that while many companies were trying to increase the capacity of the drives, other companies changed the form factor and made the drives smaller. This resulted in disruptive progress in the industry. We also recently witnessed dramatic advances in artificial intelligence (AI), where in 2013/2014 AI systems started outperforming humans in image recognition.

Identifying novel targets and designing novel molecules is not the only way to innovate in the biopharmaceutical industry. Sometimes, innovation in delivery systems for well-know and established therapeutics may be just as disruptive as the new targeted medicine.

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00:00 Intro.
02:44 Kernel Flow brain interface.
08:03 Seeing my brain activity.
12:42 Reversing aging-Project Blueprint.
18:18 Overcoming depression.
26:42 Starting Kernel.
34:40 Why non-invasive?
36:43 Comparison to Tesla/ Neuralink.
43:52 Elon considered joining Kernel?
44:52 Kernel hiring.
46:17 Participate in the studies.

Participate & experience Kernel Flow: https://www.kernel.com/participate.
Information: Kernel Flow: https://www.kernel.com/flow.
Kernel Careers: https://jobs.lever.co/kernel-2
Neura Pod Episode about Kernel & Bryan Johnson: https://youtu.be/c0VFiEhDg6I
Bryan Johnson LinkedIn: https://www.linkedin.com/in/bryanrjohnson/
Bryan Johnson Personal Page: https://www.bryanjohnson.co/
Blueprint Website: https://blueprint.bryanjohnson.co/

After selling his company, Braintree/Venmo, for $800 million and battling chronic depression for 10 years, Bryan Johnson is now on a mission to help us measure and gather more data about the organ that makes us oh-so human: our brain.

In this episode, Ryan Tanaka and Omar Olivares share an exclusive, behind the scenes look of Kernel’s headquarters near Los Angeles, California. Ryan interviews Bryan Johnson, tries on Kernel’s wearable brain-interface, ‘Flow,’ and learns about the engineering and technology developments needed to make it all happen. CTO, Ryan Field and Director of Applied Neuroscience, Katherine Perdue also share insights about Kernel’s wearable Flow headset.

Disclaimer: Thanks to Kernel for opening their office for us to film in and for supporting our travel and accommodation.

Neura Pod is a series covering topics related to Neuralink, Inc. Topics such as brain-machine interfaces, brain injuries, and artificial intelligence will be explored. Host Ryan Tanaka synthesizes informationopinions, and conducts interviews to easily learn about Neuralink and its future.

Continue reading “Elon Musk’s NEURALINK vs Bryan Johnson’s KERNEL (No Surgery)” | >

A fundamental discovery concerning a driver of healthy development in embryos might rewrite our understanding of what we can inherit from our parents and how their life experiences shape us. The new study reveals that epigenetic information, which sits on top of DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

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Before the first clinical symptoms appear, Alzheimer’s.

Alzheimer’s disease is a disease that attacks the brain, causing a decline in mental ability that worsens over time. It is the most common form of dementia and accounts for 60 to 80 percent of dementia cases. There is no current cure for Alzheimer’s disease, but there are medications that can help ease the symptoms.

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The findings also point to possible directions for treatment of the disease.

The results are published Sept. 6 in the journal Neuron.

Almost half the human genome is comprised of transposable elements, long and short stretches of DNA called “jumping genes” for their ability to move from one location of the genome to others. Once called “junk” DNA, these transposable sequences have been shown to play crucial regulatory roles in many biological functions. Once they fulfill these myriad roles, molecular regulators usually silence their expression.

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